Artículo

Schanton, M.; Maymó, J.L.; Pérez-Pérez, A.; Sánchez-Margalet, V.; Varone, C.L. "Involvement of leptin in the molecular physiology of the placenta" (2018) Reproduction. 155(1):R1-R12
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Abstract:

Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein synthesis and the expression of tolerogenic maternal response molecules such as HLA-G. Leptin also exerts an anti-apoptotic action in placenta controlling the expression of p53 master cell cycle regulator under different stress conditions. On the other hand, leptin is an integrative target of different placental stimuli. The expression of leptin in placenta is regulated by hCG, insulin, steroids, hypoxia and many other growth hormones, suggesting that it might have an important endocrine function in the trophoblastic cells. The leptin expression is induced involving the cAMP/PKA or cAMP/Epac pathways which have profound actions upon human trophoblast function. The activation of PI3K and MAPK pathways also participates in the leptin expression. Estrogens play a central role during pregnancy, particularly 17β-estradiol upregulates the leptin expression in placental cells through genomic and non-genomic actions. The leptin promoter analysis reveals specific elements that are active in placental cells. The transcription factors CREB, AP1, Sp1, NFκB and the coactivator CBP are involved in the placental leptin expression. Moreover, placental leptin promoter is a target of epigenetic marks such as DNA methylation and histone acetylation that regulates not only the leptin expression in placenta during pregnancy but also determines the predisposition of acquiring adult metabolism diseases. Taken together, all these results allow a better understanding of leptin function and regulatory mechanisms of leptin expression in human placental trophoblasts, and support the importance of leptin during pregnancy and in programming adult health. © 2018 Society for Reproduction and Fertility.

Registro:

Documento: Artículo
Título:Involvement of leptin in the molecular physiology of the placenta
Autor:Schanton, M.; Maymó, J.L.; Pérez-Pérez, A.; Sánchez-Margalet, V.; Varone, C.L.
Filiación:Departamento de Química Biológica, Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
Universidad de Buenos Aires, CONICET, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina
Departamento de Bioquímica Médica y Biología Molecular, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
Palabras clave:cyclic AMP dependent protein kinase; DNA; estrogen; histone; leptin; placental peptide hormone; protein p53; transcription factor; transcription factor Sp1; leptin; Article; cell differentiation; cell proliferation; cell survival; disease predisposition; DNA methylation; epigenetics; histone acetylation; homeostasis; human; metabolic disorder; molecular biology; nuclear reprogramming; placenta; preeclampsia; pregnancy; pregnancy diabetes mellitus; priority journal; promoter region; protein expression; protein function; protein induction; protein modification; regulatory mechanism; signal transduction; spontaneous abortion; trophoblast; uterus; animal; cytology; female; metabolism; physiology; placenta; Animals; Female; Humans; Leptin; Placenta; Pregnancy; Signal Transduction
Año:2018
Volumen:155
Número:1
Página de inicio:R1
Página de fin:R12
DOI: http://dx.doi.org/10.1530/REP-17-0512
Título revista:Reproduction
Título revista abreviado:Reproduction
ISSN:14701626
CODEN:RCUKB
CAS:cyclic AMP dependent protein kinase; DNA, 9007-49-2; histone, 9062-68-4; Leptin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14701626_v155_n1_pR1_Schanton

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Citas:

---------- APA ----------
Schanton, M., Maymó, J.L., Pérez-Pérez, A., Sánchez-Margalet, V. & Varone, C.L. (2018) . Involvement of leptin in the molecular physiology of the placenta. Reproduction, 155(1), R1-R12.
http://dx.doi.org/10.1530/REP-17-0512
---------- CHICAGO ----------
Schanton, M., Maymó, J.L., Pérez-Pérez, A., Sánchez-Margalet, V., Varone, C.L. "Involvement of leptin in the molecular physiology of the placenta" . Reproduction 155, no. 1 (2018) : R1-R12.
http://dx.doi.org/10.1530/REP-17-0512
---------- MLA ----------
Schanton, M., Maymó, J.L., Pérez-Pérez, A., Sánchez-Margalet, V., Varone, C.L. "Involvement of leptin in the molecular physiology of the placenta" . Reproduction, vol. 155, no. 1, 2018, pp. R1-R12.
http://dx.doi.org/10.1530/REP-17-0512
---------- VANCOUVER ----------
Schanton, M., Maymó, J.L., Pérez-Pérez, A., Sánchez-Margalet, V., Varone, C.L. Involvement of leptin in the molecular physiology of the placenta. Reproduction. 2018;155(1):R1-R12.
http://dx.doi.org/10.1530/REP-17-0512