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Abstract:

The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic-pituitary-gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action. © 2014 Society for Reproduction and Fertility.

Registro:

Documento: Artículo
Título:Mouse models of altered gonadotrophin action: Insight into male reproductive disorders
Autor:Jonas, K.C.; Oduwole, O.O.; Peltoketo, H.; Rulli, S.B.; Huhtaniemi, I.T.
Filiación:Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London, W12 0NN, United Kingdom
Biocenter Oulu, University of Oulu, PO Box 5000, Oulu, FI-90014, Finland
Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490 (1428), Buenos Aires, Argentina
Department of Physiology, University of Turku, Kiinamyllynkatu 10, Turku, FI-20520, Finland
Palabras clave:chorionic gonadotropin; follitropin; follitropin receptor; gonadotropin; luteinizing hormone; luteinizing hormone receptor; testosterone; follitropin; follitropin receptor; gonadotropin; luteinizing hormone; luteinizing hormone receptor; androgen therapy; gain of function mutation; genetically engineered mouse strain; hormone action; loss of function mutation; male; male genital system disease; nonhuman; Review; animal; genetics; genotype; male infertility; metabolism; mouse; pathophysiology; phenotype; reproduction; signal transduction; transgenic mouse; Animals; Follicle Stimulating Hormone; Genotype; Gonadotropins; Infertility, Male; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Phenotype; Receptors, FSH; Receptors, LH; Reproduction; Signal Transduction
Año:2014
Volumen:148
Número:4
Página de inicio:R63
Página de fin:R70
DOI: http://dx.doi.org/10.1530/REP-14-0302
Título revista:Reproduction
Título revista abreviado:Reproduction
ISSN:14701626
CODEN:RCUKB
CAS:chorionic gonadotropin, 9002-61-3; follitropin, 9002-68-0; gonadotropin, 63231-54-9; luteinizing hormone, 39341-83-8, 9002-67-9; testosterone, 58-22-0; Follicle Stimulating Hormone; Gonadotropins; Luteinizing Hormone; Receptors, FSH; Receptors, LH
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14701626_v148_n4_pR63_Jonas

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Citas:

---------- APA ----------
Jonas, K.C., Oduwole, O.O., Peltoketo, H., Rulli, S.B. & Huhtaniemi, I.T. (2014) . Mouse models of altered gonadotrophin action: Insight into male reproductive disorders. Reproduction, 148(4), R63-R70.
http://dx.doi.org/10.1530/REP-14-0302
---------- CHICAGO ----------
Jonas, K.C., Oduwole, O.O., Peltoketo, H., Rulli, S.B., Huhtaniemi, I.T. "Mouse models of altered gonadotrophin action: Insight into male reproductive disorders" . Reproduction 148, no. 4 (2014) : R63-R70.
http://dx.doi.org/10.1530/REP-14-0302
---------- MLA ----------
Jonas, K.C., Oduwole, O.O., Peltoketo, H., Rulli, S.B., Huhtaniemi, I.T. "Mouse models of altered gonadotrophin action: Insight into male reproductive disorders" . Reproduction, vol. 148, no. 4, 2014, pp. R63-R70.
http://dx.doi.org/10.1530/REP-14-0302
---------- VANCOUVER ----------
Jonas, K.C., Oduwole, O.O., Peltoketo, H., Rulli, S.B., Huhtaniemi, I.T. Mouse models of altered gonadotrophin action: Insight into male reproductive disorders. Reproduction. 2014;148(4):R63-R70.
http://dx.doi.org/10.1530/REP-14-0302