Abstract:
Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort. Materials and methods: Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions. Results: Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of follow-up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T-cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors. Conclusions: The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment. © 2010 British HIV Association.
Registro:
Documento: |
Artículo
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Título: | Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites |
Autor: | Belloso, W.H.; Orellana, L.C.; Grinsztejn, B.; Madero, J.S.; La Rosa, A.; Veloso, V.G.; Sanchez, J.; Ismerio Moreira, R.; Crabtree-Ramirez, B.; Garcia Messina, O.; Lasala, M.B.; Peinado, J.; Losso, M.H. |
Filiación: | Hospital Italiano and CICAL, Buenos Aires, Argentina Instituto de Cálculo, Universidad de Buenos Aires, Argentina Instituto de Pesquisa Clínica Evandro Chagas-FIOCRUZ, Rio de Janeiro, Brazil Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico DF, Mexico INMENSA, Lima, Peru Hospital Parmenio Piñero, Buenos Aires, Argentina Hospital de Clínicas José de San Martín, Buenos Aires, Argentina Hospital JM Ramos Mejía and CICAL, Buenos Aires, Argentina
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Palabras clave: | AIDS; Cardiovascular disease; CD4 cell lymphocyte count; Cohort studies; Liver diseases; Neoplasms; acute kidney failure; adult; alcohol abuse; area under the curve; article; cardiovascular effect; CD4 lymphocyte count; cohort analysis; controlled study; diabetes mellitus; female; follow up; hepatitis B; hepatitis C; human; Human immunodeficiency virus infected patient; incidence; liver failure; logistic regression analysis; major clinical study; male; mixed infection; priority journal; retrospective study; risk factor; Acquired Immunodeficiency Syndrome; Adult; Anti-Retroviral Agents; Cardiovascular Diseases; CD4 Lymphocyte Count; Epidemiologic Methods; Female; HIV Infections; Humans; Immunocompromised Host; Liver Diseases; Male; Middle Aged; Neoplasms; Renal Insufficiency; South America |
Año: | 2010
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Volumen: | 11
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Número: | 9
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Página de inicio: | 554
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Página de fin: | 564
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DOI: |
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x |
Título revista: | HIV Medicine
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Título revista abreviado: | HIV Med.
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ISSN: | 14642662
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CODEN: | HMIEA
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CAS: | Anti-Retroviral Agents
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14642662_v11_n9_p554_Belloso |
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Citas:
---------- APA ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., Sanchez, J.,..., Losso, M.H.
(2010)
. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites. HIV Medicine, 11(9), 554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x---------- CHICAGO ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., et al.
"Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites"
. HIV Medicine 11, no. 9
(2010) : 554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x---------- MLA ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., et al.
"Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites"
. HIV Medicine, vol. 11, no. 9, 2010, pp. 554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x---------- VANCOUVER ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., et al. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites. HIV Med. 2010;11(9):554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x