Artículo

Belloso, W.H.; Orellana, L.C.; Grinsztejn, B.; Madero, J.S.; La Rosa, A.; Veloso, V.G.; Sanchez, J.; Ismerio Moreira, R.; Crabtree-Ramirez, B.; Garcia Messina, O.; Lasala, M.B.; Peinado, J.; Losso, M.H. "Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites" (2010) HIV Medicine. 11(9):554-564
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Abstract:

Objective: Acquired immune deficiency appears to be associated with serious non-AIDS (SNA)-defining conditions such as cardiovascular disease, liver and renal insufficiency and non-AIDS-related malignancies. We analysed the incidence of, and factors associated with, several SNA events in the LATINA retrospective cohort. Materials and methods: Cases of SNA events were recorded among cohort patients. Three controls were selected for each case from cohort members at risk. Conditional logistic models were fitted to estimate the effect of traditional risk factors as well as HIV-associated factors on non-AIDS-defining conditions. Results: Among 6007 patients in follow-up, 130 had an SNA event (0.86 events/100 person-years of follow-up) and were defined as cases (40 with cardiovascular events, 54 with serious liver failure, 35 with non-AIDS-defining malignancies and two with renal insufficiency). Risk factors such as diabetes, hepatitis B and C virus coinfections and alcohol abuse showed an association with events, as expected. The last recorded CD4 T-cell count prior to index date (P=0.0056, with an average difference of more than 100 cells/μL) and area under the CD4 cell curve in the year previous to index date (P=0.0081) were significantly lower in cases than in controls. CD4 cell count at index date was significantly associated with the outcome after adjusting for risk factors. Conclusions: The incidence and type of SNA events found in this Latin American cohort are similar to those reported in other regions. We found a significant association between immune deficiency and the risk of SNA events, even in patients under antiretroviral treatment. © 2010 British HIV Association.

Registro:

Documento: Artículo
Título:Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites
Autor:Belloso, W.H.; Orellana, L.C.; Grinsztejn, B.; Madero, J.S.; La Rosa, A.; Veloso, V.G.; Sanchez, J.; Ismerio Moreira, R.; Crabtree-Ramirez, B.; Garcia Messina, O.; Lasala, M.B.; Peinado, J.; Losso, M.H.
Filiación:Hospital Italiano and CICAL, Buenos Aires, Argentina
Instituto de Cálculo, Universidad de Buenos Aires, Argentina
Instituto de Pesquisa Clínica Evandro Chagas-FIOCRUZ, Rio de Janeiro, Brazil
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico DF, Mexico
INMENSA, Lima, Peru
Hospital Parmenio Piñero, Buenos Aires, Argentina
Hospital de Clínicas José de San Martín, Buenos Aires, Argentina
Hospital JM Ramos Mejía and CICAL, Buenos Aires, Argentina
Palabras clave:AIDS; Cardiovascular disease; CD4 cell lymphocyte count; Cohort studies; Liver diseases; Neoplasms; acute kidney failure; adult; alcohol abuse; area under the curve; article; cardiovascular effect; CD4 lymphocyte count; cohort analysis; controlled study; diabetes mellitus; female; follow up; hepatitis B; hepatitis C; human; Human immunodeficiency virus infected patient; incidence; liver failure; logistic regression analysis; major clinical study; male; mixed infection; priority journal; retrospective study; risk factor; Acquired Immunodeficiency Syndrome; Adult; Anti-Retroviral Agents; Cardiovascular Diseases; CD4 Lymphocyte Count; Epidemiologic Methods; Female; HIV Infections; Humans; Immunocompromised Host; Liver Diseases; Male; Middle Aged; Neoplasms; Renal Insufficiency; South America
Año:2010
Volumen:11
Número:9
Página de inicio:554
Página de fin:564
DOI: http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x
Título revista:HIV Medicine
Título revista abreviado:HIV Med.
ISSN:14642662
CODEN:HMIEA
CAS:Anti-Retroviral Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14642662_v11_n9_p554_Belloso

Referencias:

  • Mocroft, A., Ledergerber, B., Katlama, C., et al, Decline in the AIDS and death rates in the EuroSIDA study: an observational study (2003) Lancet, 362, pp. 22-29
  • Lundgren, J.D., Mocroft, A., The impact of antiretroviral therapy on AIDS and survival (2006) J HIV Ther, 2, pp. 36-38
  • Mocroft, A., Phillips, A.N., Lundgren, J.D., HIV survival benefit associated with earlier antiviral therapy (2004) Ann Intern Med, 140, pp. 578-579
  • Short-term risk of AIDS according to current CD4 cell cell count and viral load in antiretroviral drug-naïve individuals and in those treated in the monotherapy era (2004) AIDS, 18, pp. 51-58. , CASCADE Collaboration
  • Egger, M., May, M., Chene, G., et al, Prognosis of HIV-1 infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies (2002) Lancet, 360, pp. 119-129
  • Lau, B., Gange, S., Moore, R.D., Risk of non-AIDS related mortality may exceed risk of AIDS-related mortality among individuals enrolling into care with CD4 cell+counts greater than 200 cells/mm3 (2007) J Acquir Immune Defic Syndr, 44, pp. 179-187
  • Weber, R., Sabin, C.A., Friis-Møller, N., et al, Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study (2006) Arch Intern Med, 166, pp. 1632-1641
  • Smit, C., Geskus, R., Walker, S., et al, Effective therapy has altered the spectrum of cause-specific mortality following HIV seroconversion (2006) AIDS, 20, pp. 741-749
  • Palella, F.J., Baker, R.K., Moorman, A.C., et al, Mortality in the highly active antiretroviral therapy era. Changing causes of death and disease in the HIV outpatient study (2006) J Acquir Immun Defic Syndr, 43, pp. 27-34
  • Baker, J.V., Peng, G., Rapkin, J., et al, CD4 cell+count and risk of non-AIDS diseases following initial treatment for HIV infection (2008) AIDS, 22, pp. 841-848
  • Liver-related deaths in persons infected with the human immunodeficiency virus (2006) Arch Intern Med, 166, pp. 1632-1641. , D:A:D Study Group
  • Monforte, A., Abrams, D., Pradier, C., et al, HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies (2008) AIDS, 22, pp. 2143-2153
  • El-Sadr, W.M., Lundgren, J.D., Neaton, J.D., et al, CD4+count-guided interruption of antiretroviral treatment (2006) N Engl J Med, 355, pp. 2283-2296. , for the Strategies for Management of Antiretroviral Therapy (SMART) Study Group
  • Emery, S., Neuhaus, J.A., Phillips, A.N., et al, Major clinical outcomes in antiretroviral therapy (ART)-naïve participants and in those not receiving ART at baseline in the SMART Study (2008) J Infect Dis, 197, pp. 1133-1144. , for the Strategies for Management of Antiretroviral Therapy (SMART) Study Group
  • Crum, N.F., Riffenburgh, R.H., Wegner, S., et al, Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early and late HAART (highly active antiretroviral therapy) eras (2006) J Acquir Immune Defic Syndr, 41, pp. 194-200
  • Mocroft, A., Brettle, R., Kirk, O., et al, Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study (2002) AIDS, 16, pp. 1663-1671
  • Baker, J.V., Peng, G., Rapkin, J., et al, Poor initial CD4 cell+recovery with antiretroviral therapy prolongs immune depletion and increases risk of AIDS and non-AIDS diseases (2008) JAIDS, 48, pp. 541-546
  • Bautista-Arredondo, S., Gadsden, P., Harris, J.E., Bertozzi, S.M., Optimizing resource allocation for HIV/AIDS prevention programmes: an analytical framework (2008) AIDS, 22 (SUPPL. 1), pp. S67-S74
  • (2008), pp. 129-159. , Joint United Nations Programme on HIV/AIDS (UNAIDS)., Treatment and care: unprecedented progress, remaining challenges. Report on the global AIDS epidemic; Chequer, P., Cuchi, P., Mazin, R., García Calleja, J.M., Access to antiretroviral treatment in Latin American countries and the Caribbean (2002) AIDS, 16 (SUPPL. 3), pp. S50-S57
  • Bastos, F.I., Cáceres, C., Galvao, J., Veras, M.A., Castilho, E.A., AIDS in Latin America: assessing the current status of the epidemic and the ongoing response (2008) Int J Epidemiol, 37, pp. 729-737
  • Rothman, K.J., Greenland, S., Lash, T.L., (2008) Modern Epidemiology, , 3rd ed, Philadelphia, PA, USA, Lippincott, Williams & Wilkins
  • Robins, J., Gail, M.G., Lubin, J.H., More on 'biased selection of controls for case-control analysis of cohort studies' (1986) Biometrics, 42, pp. 293-299
  • Knol, M.J., Vandenbroucke, J.P., Scott, P., Egger, M., What do case-control studies estimate? Survey of methods and assumptions in published case-control research (2008) Am J Epidemiol, 168, pp. 1073-1081
  • McQueen, M.J., Hawken, S., Wang, X., et al, Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study (2008) Lancet, 372, pp. 224-233
  • Kuller, L.H., Tracy, R., Belloso, W.H., et al, Inflammation and coagulation biomarkers and mortality in patients with HIV infection (2008) PLoS Med, 5, pp. e203
  • Mu, H., Chai, H., Lin, P.H., Yao, Q., Chen, C., Current update on HIV-associated vascular disease and endothelial dysfunction (2007) World J Surg, 31, pp. 632-643
  • Mehta, N., Reilly, M., Atherosclerotic cardiovascular disease risk in the HAART-treated HIV-1 population (2005) HIV Clin Trials, 6, pp. 5-24
  • Stein, J.H., Klein, M.A., Bellehumeur, J.L., et al, Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction (2001) Circulation, 104, pp. 257-262
  • Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration (2008) Lancet, 371, pp. 1417-1426. , D:A:D Study Group
  • Thein, H.H., Yi, Q., Dore, G.J., Krahn, M.D., Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis (2008) AIDS, 22, pp. 1979-1991
  • Bottecchia, M., Garcia-Samaniego, J., Soriano, V., The implications of antiviral drugs with activity against hepatitis B virus and HIV (2007) Curr Opin Infect Dis, 20, pp. 621-628
  • Puoti, M., Torti, C., Bruno, R., Filice, G., Carosi, G., Natural history of chronic hepatitis B in co-infected patients (2006) J Hepatol, 44 (SUPPL.), pp. S65-S70
  • Class of antiretroviral drugs and the risk of myocardial infarction (2007) N Engl J Med, 356, pp. 1723-1735. , DAD Study Group
  • Moore, R.D., Gebo, K.A., Lucas, G.M., Keruly, J.C., Rate of comorbidities not related to HIV infection or AIDS among HIV-infected patients, by CD4 cell cell count and HAART use status (2008) Clin Infect Dis, 47, pp. 1102-1104
  • Crabtree-Ramirez, B., Gómez Palacio, M., Rodríguez Rivera, V., Reyes-Terán, G., Baseline characteristics of HIV-infected patients attending a National Institute of Health in Mexico City: evidence of late detection of HIV infection and the urgent need for efficient. Voluntary Counseling and Testing (VCT) programs. Mexico DF, Mexico, August 2008. [Abstract THPE0244]

Citas:

---------- APA ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., Sanchez, J.,..., Losso, M.H. (2010) . Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites. HIV Medicine, 11(9), 554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x
---------- CHICAGO ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., et al. "Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites" . HIV Medicine 11, no. 9 (2010) : 554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x
---------- MLA ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., et al. "Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites" . HIV Medicine, vol. 11, no. 9, 2010, pp. 554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x
---------- VANCOUVER ----------
Belloso, W.H., Orellana, L.C., Grinsztejn, B., Madero, J.S., La Rosa, A., Veloso, V.G., et al. Analysis of serious non-AIDS events among HIV-infected adults at Latin American sites. HIV Med. 2010;11(9):554-564.
http://dx.doi.org/10.1111/j.1468-1293.2010.00824.x