Artículo

Pettinari, M.J.; Nikel, P.I.; Ruiz, J.A.; Méndez, B.S. "ArcA redox mutants as a source of reduced bioproducts" (2008) Journal of Molecular Microbiology and Biotechnology. 15(1):41-47
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Escherichia coli and other facultative anaerobes can adapt their metabolism according to oxygen availability by means of aerobic and anaerobic respiration and fermentation. ArcAB is a two-component signal transduction system that controls, at the transcriptional level, the choice of energy generation pathway according to the intracellular redox state. High throughput studies on different redox regulator mutants, involving transcriptome analysis, RT-PCR and phenotypic arrays enabled the elucidation of a repertoire of operons coordinated by ArcA which extended beyond respiration control including, among others, those which code for survival, chromosome replication and degradation of fatty acids. Flux analysis by 13C labeling provided new clues to the understanding of the distribution of metabolites mediated by ArcAB. The genetic manipulation of this regulator proved to be useful for the generation of reduced products of commercial value. Copyright © 2008 S. Karger AG.

Registro:

Documento: Artículo
Título:ArcA redox mutants as a source of reduced bioproducts
Autor:Pettinari, M.J.; Nikel, P.I.; Ruiz, J.A.; Méndez, B.S.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigaciones Biotecnológicas, Universidad de San Martín, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, C1428EGA, Buenos Aires, Argentina
Palabras clave:ArcA mutants; ArcAB; ArcAB modulon; Metabolic flux analysis; Polyhydroxybutyrate; fatty acid; transcriptome; chromosome replication; Escherichia coli; gene isolation; gene mutation; genetic trait; phenotype; real time polymerase chain reaction; respiration control; review; Bacterial Outer Membrane Proteins; Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Regulator; Oxidation-Reduction; Oxygen; Repressor Proteins; Signal Transduction; Arca; Escherichia coli
Año:2008
Volumen:15
Número:1
Página de inicio:41
Página de fin:47
DOI: http://dx.doi.org/10.1159/000111991
Título revista:Journal of Molecular Microbiology and Biotechnology
Título revista abreviado:J. Mol. Microbiol. Biotechnol.
ISSN:14641801
CODEN:JMMBF
CAS:arcA protein, E coli; Bacterial Outer Membrane Proteins; Bacterial Proteins; Escherichia coli Proteins; Oxygen, 7782-44-7; Repressor Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14641801_v15_n1_p41_Pettinari

Referencias:

  • Alexeeva, S., Hellingwerf, K.J., Teixeira de Mattos, M.J., Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditions (2003) J Bacteriol, 185, pp. 204-209
  • Anderson, A.J., Dawes, E.A., Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates (1990) Microbiol Rev, 54, pp. 450-472
  • Becker, S., Vlad, D., Schuster, S., Pfeiffer, P., Unden, G., Regulatory O 2 tensions for the synthesis of fermentation products in Escherichia coli and relation to aerobic respiration (1997) Arch Microbiol, 168, pp. 290-296
  • Bochner, B.R., Gadzinski, P., Panomitros, E., Phenotype microarrays for high-throughput phenotypic testing and assay of gene function (2001) Genome Res, 11, pp. 1246-1255
  • Carlson, R., Wlaschin, A., Srienc, F., Kinetic studies and biochemical pathway analysis of anaerobic poly-(R)-3-hydroxybutyric acid synthesis in Escherichia coli (2005) Appl Environ Microbiol, 71, pp. 713-720
  • Cho, B.K., Knight, E.M., Palsson, B., Transcriptional regulation of the fad regulon genes of Escherichia coli by ArcA (2006) Microbiology, 152, pp. 2207-2219
  • Colloms, S.D., Alen, C., Sherratt, D.J., The ArcA/ArcB two-component regulatory system of Escherichia coli is essential for Xer site-specific recombination at psi (1998) Mol Microbiol, 28, pp. 521-530
  • Compan, I., Touati, D., Anaerobic activation of arcA transcription in Escherichia coli: Roles of Fnr and ArcA (1994) Mol Microbiol, 11, pp. 955-964
  • Dibden, D.P., Green, J., In vivo cycling of the Escherichia coli transcription factor FNR between active and inactive states (2005) Microbiology, 151, pp. 4063-4070
  • Drury, L.S., Buxton, R.S., DNA sequence analysis of the dye gene of Escherichia coli reveals amino acid homology between the dye and OmpR proteins (1985) J Biol Chem, 260, pp. 4236-4242
  • Georgellis, D., Kwon, O., Lin, E.C.C., Quinones as the redox signal for the arc two-component system of bacteria (2001) Science, 292, pp. 2314-2346
  • González, R., Tao, H., Shanmugam, K.T., York, S.W., Ingram, L.O., Global gene expression differences associated with changes in glycolytic flux and growth rate in Escherichia coli during the fermentation of glucose and xylose (2002) Biotechnol Prog, 18, pp. 6-20
  • Gunsalus, R.P., Control of electron flow in Escherichia coli: Coordinated transcription of respiratory pathway genes (1992) J Bacteriol, 174, pp. 7069-7074
  • Iuchi, S., Phosphorylation/dephosphorylation of the receiver module at the conserved aspartate residue controls transphosphorylation activity of histidine kinase in sensor protein ArcB of Escherichia coli (1993) J Biol Chem, 268, pp. 23972-23980
  • Iuchi, S., Cameron, D.C., Lin, E.C.C., A second global regulator gene (arcB) mediating repression of enzymes in aerobic pathways of Escherichia coli (1989) J Bacteriol, 171, pp. 868-873
  • Iuchi, S., Furlong, D., Lin, E.C.C., Differentiation of arcA, arcB, and cpxA mutant phenotypes of Escherichia coli by sex pilus formation and enzyme regulation (1989) J Bacteriol, 171, pp. 2889-2893
  • Iuchi, S., Lin, E.C.C., arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways (1988) Proc Natl Acad Sci USA, 85, pp. 1888-1892
  • Iuchi, S., Lin, E.C.C., Mutational analysis of signal transduction by ArcB, a membrane sensor protein responsible for anaerobic repression of operons involved in the central aerobic pathways in Escherichia coli (1992) J Bacteriol, 174, pp. 3972-3980
  • Iuchi, S., Matsuda, Z., Fujiwara, T., Lin, E.C.C., The arcB gene of Escherichia coli encodes a sensor-regulator protein for anaerobic repression of the arc modulon (1990) Mol Microbiol, 4, pp. 715-727
  • Jeon, Y., Lee, Y.S., Han, J.S., Kim, J.B., Hwang, D.S., Multimerization of phosphorylated and non-phosphorylated ArcA is necessary for the response regulator function of the Arc two-component signal transduction system (2001) J Biol Chem, 276, pp. 40873-40879
  • Kang, Y., Weber, K.D., Qiu, Y., Kiley, P.J., Blattner, F.R., Genome-wide expression analysis indicates that FNR of Escherichia coli K-12 regulates a large number of genes of unknown function (2005) J Bacteriol, 187, pp. 1135-1160
  • Kato, M., Mizuno, T., Shimizu, T., Hakoshima, T., Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB (1997) Cell, 88, pp. 717-723
  • Kwon, O., Georgellis, D., Lin, E.C.C., Phosphorelay as the sole physiological route of signal transmission by the arc two-component system of Escherichia coli (2000) J Bacteriol, 182, pp. 3858-3862
  • Kwon, O., Georgellis, D., Lynch, A.S., Boyd, D., Lin, E.C.C., The ArcB sensor kinase of Escherichia coli: Genetic exploration of the transmembrane region (2000) J Bacteriol, 182, pp. 2960-2966
  • Lara, A.R., Leal, L., Flores, N., Gosset, G., Bolívar, F., Ramírez, O.T., Transcriptional and metabolic response of recombinant Escherichia coli to spatial dissolved oxygen tension gradients simulated in a scale-down system (2006) Biotechnol Bioeng, 93, pp. 372-385
  • Lee, Y.S., Han, J.S., Jeon, Y., Hwang, D.S., The arc two-component signal transduction system inhibits in vitro Escherichia coli chromosomal initiation (2001) J Biol Chem, 276, pp. 9917-9923
  • Li, B., Wing, H., Lee, D., Wu, H.C., Busby, S., Transcription activation by Escherichia coli FNR protein: Similarities to, and differences from, the CRP paradigm (1998) Nucleic Acids Res, 26, pp. 2075-2081
  • Liu, X., De Wulf, P., Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling (2004) J Biol Chem, 279, pp. 12588-12597
  • Lynch, A.S., Lin, E.C.C., Responses to molecular oxygen (1996) Escherichia coli and Salmonella: Cellular and Molecular Biology, 1, pp. 1526-1538. , Neidhardt FC, Curtiss III RJ, Ingraham L, Lin ECC, Low KB, Magasanik BW, Reznikoff S, Riley M, Schaechter M, Umbarger HE eds, ed 2. Washington, American Society for Microbiology
  • Madison, L.L., Huisman, G.W., Metabolic engineering of poly(3- hydroxyalkanoates): From DNA to plastic (1999) Microbiol Mol Biol Rev, 63, pp. 21-53
  • Malpica, R., Franco, B., Rodríguez, C., Kwon, O., Georgellis, D., Identification of a quinone-sensitive redox switch in the ArcB sensor kinase (2004) Proc Natl Acad Sci USA, 101, pp. 13318-13323
  • Malpica, R., Sandoval, G.R., Rodríguez, C., Franco, B., Georgellis, D., Signaling by the arc two-component system provides a link between the redox state of the quinone pool and gene expression (2006) Antioxid Redox Signal, 8, pp. 781-795
  • Mika, F., Hengge, R., A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of σS (RpoS) in E. coli (2005) Genes Dev, 19, pp. 2770-2781
  • Nikel, P.I., Pettinari, M.J., Galvagno, M.A., Méndez, B.S., Poly(3-hydroxybutyrate) synthesis by recombinant Escherichia coli arcA mutants in microaerobiosis (2006) Appl Environ Microbiol, 72, pp. 2614-2620
  • Nyström, T., The glucose-starvation stimulon of Escherichia coli: Induced and repressed synthesis of enzymes of central metabolic pathways and role of acetyl phosphate in gene expression and starvation survival (1994) Mol Microbiol, 12, pp. 833-843
  • Nyström, T., Larsson, C., Gustafsson, L., Bacterial defense against aging: Role of the Escherichia coli ArcA regulator in gene expression, readjusted energy flux and survival during stasis (1996) EMBO J, 15, pp. 3219-3228
  • Oh, M.K., Liao, J.C., Gene expression profiling by DNA microarrays and metabolic fluxes in Escherichia coli (2000) Biotechnol Prog, 16, pp. 278-286
  • Ogasawara, H., Teramoto, J., Yamamoto, S., Hirao, K., Yamamoto, K., Ishihama, A., Utsumi, R., Negative regulation of DNA repair gene (uvrA) expression by ArcA/ArcB two-component system in Escherichia coli (2005) FEMS Microbiol Lett, 251, pp. 243-249
  • Parkinson, J.S., Kofoid, E.C., Communication modules in bacterial signaling proteins (1992) Annu Rev Genet, 26, pp. 71-112
  • Patschkowski, T., Bates, D.N., Kiley, P.J., Mechanisms for sensing and responding to oxygen deprivation (2000) Bacterial Stress Responses, pp. 61-78. , Storz G, Hengge-Aronis R eds, Washington, American Society for Microbiology
  • Peña-Sandoval, G.R., Kwon, O., Georgellis, D., Requirement of the receiver and phosphotransfer domains of ArcB for efficient dephosphorylation of phosphorylated ArcA in vivo (2005) J Bacteriol, 187, pp. 3267-3272
  • Perrenoud, A., Sauer, U., Impact of global transcriptional regulation by ArcA, ArcB, Cra, Crp, Cya, Fnr, and Mlc on glucose catabolism in Escherichia coli (2005) J Bacteriol, 187, pp. 3171-3179
  • Ruiz, J.A., Fernández, R.O., Nikel, P.I., Méndez, B.S., Pettinari, M.J., dye (arc) Mutants: Insights into an unexplained phenotype and its suppression by the synthesis of poly(3-hydroxybutyrate) in Escherichia coli recombinants (2006) FEMS Microbiol Lett, 258, pp. 55-60
  • Salmon, K.A., Hung, S.P., Steffen, N.R., Krupp, R., Baldi, P., Hatfield, G.W., Gunsalus, R.P., Global gene expression profiling in Escherichia coli K-12: Effects of oxygen availability and ArcA (2005) J Biol Chem, 280, pp. 15084-15096
  • Sauer, U., High-throughput phenomics: Experimental methods for mapping fluxomes (2004) Curr Opin Biotechnol, 15, pp. 58-63
  • Sawers, G., Suppmann, B., Anaerobic induction of pyruvate formate-lyase gene expression is mediated by the ArcA and FNR proteins (1992) J Bacteriol, 174, pp. 3474-3478
  • Scott, A., Biologics, coming back into balance (2004) Chemical Week, pp. 21-25. , June 2
  • Shalel-Levanon, S., San, K.Y., Bennett, G.N., Effect of oxygen on the E. coli ArcA and FNR regulation systems and metabolic responses (2005) Biotechnol Bioeng, 89, pp. 556-564
  • Shalel-Levanon, S., San, K.Y., Bennett, G.N., Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions (2005) Biotechnol Bioeng, 92, pp. 147-159
  • Shalel-Levanon, S., San, K.Y., Bennett, G.N., Effect of oxygen, and ArcA and FNR regulators on the expression of genes related to the electron transfer chain and the TCA cycle in Escherichia coli (2005) Metab Eng, 7, pp. 364-374
  • Spiro, S., The FNR family of transcriptional regulators (1994) Antonie van Leeuwenhoek, 66, pp. 23-36
  • Stock, J.B., Stock, A.M., Mottonen, J.M., Signal transduction in bacteria (1990) Nature, 344, pp. 395-400
  • Strohmaier, H., Noiges, R., Kotschan, S., Sawers, G., Hogenauer, G., Zechner, E.L., Koraimann, G., Signal transduction and bacterial conjugation: Characterization of the role of ArcA in regulating conjugative transfer of the resistance plasmid R1 (1998) J Mol Biol, 277, pp. 309-316
  • Toro-Román, A., Mack, T.R., Stock, A.M., Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: A symmetric dimer mediated by the alpha4-beta5-alpha5 face (2005) J Mol Biol, 349, pp. 11-26
  • Vemuri, G.N., Altman, E., Sangurdekar, D.P., Khodursky, A.B., Eiteman, M.A., Overflow metabolism in Escherichia coli during steady-state growth: Transcriptional regulation and effect of the redox ratio (2006) Appl Environ Microbiol, 72, pp. 3653-3661
  • Wiechert, W., 13C metabolic flux analysis (2001) Metab Eng, 3, pp. 195-206
  • Zhou, L., Lei, X.H., Bochner, B.R., Wanner, B.L., Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems (2003) J Bacteriol, 185, pp. 4956-4972
  • Zhu, J., Shalel-Levanon, S., Bennett, G.N., San, K.Y., Effect of the global redox sensing/regulation networks on Escherichia coli and metabolic flux distribution based on C-13 labelling experiments (2006) Metab Eng, 8, pp. 619-627

Citas:

---------- APA ----------
Pettinari, M.J., Nikel, P.I., Ruiz, J.A. & Méndez, B.S. (2008) . ArcA redox mutants as a source of reduced bioproducts. Journal of Molecular Microbiology and Biotechnology, 15(1), 41-47.
http://dx.doi.org/10.1159/000111991
---------- CHICAGO ----------
Pettinari, M.J., Nikel, P.I., Ruiz, J.A., Méndez, B.S. "ArcA redox mutants as a source of reduced bioproducts" . Journal of Molecular Microbiology and Biotechnology 15, no. 1 (2008) : 41-47.
http://dx.doi.org/10.1159/000111991
---------- MLA ----------
Pettinari, M.J., Nikel, P.I., Ruiz, J.A., Méndez, B.S. "ArcA redox mutants as a source of reduced bioproducts" . Journal of Molecular Microbiology and Biotechnology, vol. 15, no. 1, 2008, pp. 41-47.
http://dx.doi.org/10.1159/000111991
---------- VANCOUVER ----------
Pettinari, M.J., Nikel, P.I., Ruiz, J.A., Méndez, B.S. ArcA redox mutants as a source of reduced bioproducts. J. Mol. Microbiol. Biotechnol. 2008;15(1):41-47.
http://dx.doi.org/10.1159/000111991