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Gonzalez, M.M.; Denofrio, M.P.; García Einschlag, F.S.; Franca, C.A.; Pis Diez, R.; Erra-Balsells, R.; Cabrerizo, F.M. "Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states" (2014) Physical Chemistry Chemical Physics. 16(31):16547-16562
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Abstract:

Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and 1H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane-dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane. © the Partner Organisations 2014.

Registro:

Documento: Artículo
Título:Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
Autor:Gonzalez, M.M.; Denofrio, M.P.; García Einschlag, F.S.; Franca, C.A.; Pis Diez, R.; Erra-Balsells, R.; Cabrerizo, F.M.
Filiación:CIHIDECAR - CONICET, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, 3p, Buenos Aires, 1428, Argentina
IIB-INTECH (sede Chascomús) - UNSAM-CONICET, Intendente Marino Km 8,2. CC 164, Chascomús, Buenos Aires, 7130, Argentina
INIFTA - CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CCT La Plata-CONICET, Casilla de Correo 16 Suc. 4, La Plata, Buenos Aires, 1900, Argentina
CEQUINOR - CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 47 y 115, La Plata, Buenos Aires, 1900, Argentina
Palabras clave:indole derivative; nucleotide; chemical structure; chemistry; pH; procedures; proton nuclear magnetic resonance; spectroscopy; Hydrogen-Ion Concentration; Indoles; Models, Molecular; Nucleotides; Proton Magnetic Resonance Spectroscopy; Spectrum Analysis
Año:2014
Volumen:16
Número:31
Página de inicio:16547
Página de fin:16562
DOI: http://dx.doi.org/10.1039/c4cp01910e
Título revista:Physical Chemistry Chemical Physics
Título revista abreviado:Phys. Chem. Chem. Phys.
ISSN:14639076
CAS:Indoles; Nucleotides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14639076_v16_n31_p16547_Gonzalez

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Citas:

---------- APA ----------
Gonzalez, M.M., Denofrio, M.P., García Einschlag, F.S., Franca, C.A., Pis Diez, R., Erra-Balsells, R. & Cabrerizo, F.M. (2014) . Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states. Physical Chemistry Chemical Physics, 16(31), 16547-16562.
http://dx.doi.org/10.1039/c4cp01910e
---------- CHICAGO ----------
Gonzalez, M.M., Denofrio, M.P., García Einschlag, F.S., Franca, C.A., Pis Diez, R., Erra-Balsells, R., et al. "Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states" . Physical Chemistry Chemical Physics 16, no. 31 (2014) : 16547-16562.
http://dx.doi.org/10.1039/c4cp01910e
---------- MLA ----------
Gonzalez, M.M., Denofrio, M.P., García Einschlag, F.S., Franca, C.A., Pis Diez, R., Erra-Balsells, R., et al. "Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states" . Physical Chemistry Chemical Physics, vol. 16, no. 31, 2014, pp. 16547-16562.
http://dx.doi.org/10.1039/c4cp01910e
---------- VANCOUVER ----------
Gonzalez, M.M., Denofrio, M.P., García Einschlag, F.S., Franca, C.A., Pis Diez, R., Erra-Balsells, R., et al. Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states. Phys. Chem. Chem. Phys. 2014;16(31):16547-16562.
http://dx.doi.org/10.1039/c4cp01910e