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Abstract:

The aims of the present study were to characterize for the first time the carrageenan extracted from cystocarpic stage of S. crispata collected in the Patagonian coast of Argentina, and to prepare interpolyelectrolytic complexes (IPECs) between the polysaccharide extracted from cystocarpic stage of Sarcothalia crispata and Gigartina skottsbergii thalli, and basic butylated methacrylate copolymer (Eudragit E), in order to test their potential for the controlled release of ibuprofen as model drug. The structural determination revealed that the polysaccharides extracted from S. crispata and G. skottsbergii were mainly constituted by κ-carrageenan, particularly in the case of G. skottsbergii; however, significant amounts of ι- and ν-carrageenan were also detected in both polygalactans. The differences in diad composition and possibly in their distribution along the polysaccharide chain of both carrageenans would favor a different arrangement in the resulting IPEC structure. The smaller pores observed by scanning electron microscopy in the IPEC of S. crispata suggest that the kinks in the polysaccharide backbone are evenly distributed, resulting in a slower ibuprofen release compared to the IPEC of G. skottsbergii. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Registro:

Documento: Artículo
Título:Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release
Autor:Hughes, M.H.; Prado, H.J.; Rodríguez, M.C.; Michetti, K.; Leonardi, P.I.; Matulewicz, M.C.
Filiación:Centro de Recursos Naturales Renovables de la Zona Semiárida (CERZOS) CONICET-UNS, Camino La Carrindanga Km 7, Bahía Blanca, 8000, Argentina
Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, Bahía Blanca, 8000, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, PINMATE-Departamento de Industrias, Ciudad Universitaria, Buenos Aires, 1428EGA, Argentina
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica II, Junín 956, Buenos Aires, 1113AAD, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Ciudad Universitaria, Buenos Aires, 1428EGA, Argentina
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Centro de Investigación en Hidratos de Carbono (CIHIDECAR), Facultad de Ciencias Exactas y Naturales,Departamento de Química Orgánica, Ciudad Universitaria, Buenos Aires, 1428EGA, Argentina
Palabras clave:Carrageenan; Controlled drug release; Gigartina skottsbergii; IPECs; Sarcothalia crispata; Drug products; Scanning electron microscopy; Targeted drug delivery; Carrageenans; Controlled drug release; Gigartina skottsbergii; IPECs; Sarcothalia crispata; Controlled drug delivery; alga; biotechnology; drug; plant extract; polymer; polysaccharide; seaweed; Argentina; Patagonia; Gigartina skottsbergii; Sarcothalia crispata; carrageenan; methacrylic acid methyl ester; chemical structure; chemistry; delayed release formulation; red alga; Carrageenan; Delayed-Action Preparations; Methylmethacrylates; Molecular Structure; Rhodophyta
Año:2018
Volumen:20
Número:6
Página de inicio:706
Página de fin:717
DOI: http://dx.doi.org/10.1007/s10126-018-9842-4
Título revista:Marine Biotechnology
Título revista abreviado:Mar. Biotechnol.
ISSN:14362228
CODEN:MABIF
CAS:carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; methacrylic acid methyl ester, 80-62-6; Carrageenan; Delayed-Action Preparations; Methylmethacrylates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14362228_v20_n6_p706_Hughes

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Citas:

---------- APA ----------
Hughes, M.H., Prado, H.J., Rodríguez, M.C., Michetti, K., Leonardi, P.I. & Matulewicz, M.C. (2018) . Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. Marine Biotechnology, 20(6), 706-717.
http://dx.doi.org/10.1007/s10126-018-9842-4
---------- CHICAGO ----------
Hughes, M.H., Prado, H.J., Rodríguez, M.C., Michetti, K., Leonardi, P.I., Matulewicz, M.C. "Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release" . Marine Biotechnology 20, no. 6 (2018) : 706-717.
http://dx.doi.org/10.1007/s10126-018-9842-4
---------- MLA ----------
Hughes, M.H., Prado, H.J., Rodríguez, M.C., Michetti, K., Leonardi, P.I., Matulewicz, M.C. "Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release" . Marine Biotechnology, vol. 20, no. 6, 2018, pp. 706-717.
http://dx.doi.org/10.1007/s10126-018-9842-4
---------- VANCOUVER ----------
Hughes, M.H., Prado, H.J., Rodríguez, M.C., Michetti, K., Leonardi, P.I., Matulewicz, M.C. Carrageenans from Sarcothalia crispata and Gigartina skottsbergii: Structural Analysis and Interpolyelectrolyte Complex Formation for Drug Controlled Release. Mar. Biotechnol. 2018;20(6):706-717.
http://dx.doi.org/10.1007/s10126-018-9842-4