Artículo

Zanaro, N.L.; Romero, M.C.; Duek, F.; Imventarza, O.; Lendoire, J.; Sassetti, B. "Nitric oxide in liver transplantation" (2001) Clinical Chemistry and Laboratory Medicine. 39(10):932-936
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Abstract:

Liver transplantation is the only therapeutic option for patients with end-stage liver disease. Nitric oxide, a free radical produced from L-arginine, a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. The inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. We analyzed the relationships between the levels of nitric oxide, hepatic enzymes and other clinical parameters (glucose, total proteins, total bilirubin, creatinine, albumin) obtained in serum samples before liver transplantation and every 48 h till day 15 in 15 patients aged 40 ± 13 years. Aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study, cholinesterase levels remained decreased throughout the study and nitric oxide remained high, never reaching normal values.

Registro:

Documento: Artículo
Título:Nitric oxide in liver transplantation
Autor:Zanaro, N.L.; Romero, M.C.; Duek, F.; Imventarza, O.; Lendoire, J.; Sassetti, B.
Filiación:Departamento Quimica Biologica, Facultad Ciencias Exactas Naturales, Ciudad Universitaria, 4 piso, Pab II, 1428 Buenos Aires, Argentina
Palabras clave:Inducible (iNOS); Liver transplantation; Nitric oxide; Nitric oxide synthase; alanine aminotransferase; albumin; arginine; aspartate aminotransferase; bilirubin; cholinesterase; creatinine; cytokine; free radical; glucose; lipopolysaccharide; liver enzyme; nitric oxide; nitric oxide synthase; plasma protein; adult; alanine aminotransferase blood level; article; aspartate aminotransferase blood level; blood level; cell proliferation; cholinesterase blood level; clinical article; controlled study; endothelium; female; human; inhibition kinetics; ischemia; kidney failure; Kupffer cell; leukocyte adherence; liver circulation; liver transplantation; male; priority journal; reperfusion injury; sampling; shock; smooth muscle fiber; thrombocyte; thrombocyte adhesion; thrombocyte aggregation; vascular endothelium; vascular smooth muscle; vasodilatation; Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Blood Proteins; Cholinesterases; Creatinine; Female; Humans; Liver; Liver Failure; Liver Transplantation; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Serum Albumin
Año:2001
Volumen:39
Número:10
Página de inicio:932
Página de fin:936
DOI: http://dx.doi.org/10.1515/CCLM.2001.149
Título revista:Clinical Chemistry and Laboratory Medicine
Título revista abreviado:Clin. Chem. Lab. Med.
ISSN:14346621
CODEN:CCLMF
CAS:Alanine Transaminase, EC 2.6.1.2; Aspartate Aminotransferases, EC 2.6.1.1; Bilirubin, 635-65-4; Blood Glucose; Blood Proteins; Cholinesterases, EC 3.1.1.8; Creatinine, 60-27-5; Nitric Oxide Synthase Type II, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; NOS2A protein, human, EC 1.14.13.39; Serum Albumin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v39_n10_p932_Zanaro

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Citas:

---------- APA ----------
Zanaro, N.L., Romero, M.C., Duek, F., Imventarza, O., Lendoire, J. & Sassetti, B. (2001) . Nitric oxide in liver transplantation. Clinical Chemistry and Laboratory Medicine, 39(10), 932-936.
http://dx.doi.org/10.1515/CCLM.2001.149
---------- CHICAGO ----------
Zanaro, N.L., Romero, M.C., Duek, F., Imventarza, O., Lendoire, J., Sassetti, B. "Nitric oxide in liver transplantation" . Clinical Chemistry and Laboratory Medicine 39, no. 10 (2001) : 932-936.
http://dx.doi.org/10.1515/CCLM.2001.149
---------- MLA ----------
Zanaro, N.L., Romero, M.C., Duek, F., Imventarza, O., Lendoire, J., Sassetti, B. "Nitric oxide in liver transplantation" . Clinical Chemistry and Laboratory Medicine, vol. 39, no. 10, 2001, pp. 932-936.
http://dx.doi.org/10.1515/CCLM.2001.149
---------- VANCOUVER ----------
Zanaro, N.L., Romero, M.C., Duek, F., Imventarza, O., Lendoire, J., Sassetti, B. Nitric oxide in liver transplantation. Clin. Chem. Lab. Med. 2001;39(10):932-936.
http://dx.doi.org/10.1515/CCLM.2001.149