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Ramos, L.C.B.; Marchesi, M.S.P.; Callejon, D.; Baruffi, M.D.; Lunardi, C.N.; Slep, L.D.; Bendhack, L.M.; da Silva, R.S. "Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes" (2016) European Journal of Inorganic Chemistry. 2016(22):3592-3597
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Abstract:

We have investigated the synergistic effect of nitric oxide and singlet oxygen originating from stimulated ruthenium complexes and their photodynamic action against a melanoma cancer cell line. In aqueous solution, the photosensitizer [Ru(NH3)5pz]2+(I; pz = pyrazine) and the nitrosylruthenium complex trans-[RuCl([15]aneN4)NO]2+(II; [15]aneN4= 1,4,8,12-tetrazacyclopentadecane) can produce singlet oxygen and nitric oxide, respectively. The phototoxicity of complex I does not correlate with the singlet oxygen quantum yields unless it is mediated by nitric oxide release from complex II. This effect is around 70 and 50 % higher than the effect prompted by compounds I and II, respectively, in isolation in the presence of light. It was found that the number of hypodiploid cells in the melanoma cancer cells increased, which indicates that a mixture of compounds I and II induces apoptosis of tumorigenic cell lines. Both singlet oxygen and nitric oxide produced by the ruthenium complexes enhance the photodynamic efficacy in melanoma cancer cells. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Registro:

Documento: Artículo
Título:Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
Autor:Ramos, L.C.B.; Marchesi, M.S.P.; Callejon, D.; Baruffi, M.D.; Lunardi, C.N.; Slep, L.D.; Bendhack, L.M.; da Silva, R.S.
Filiación:Faculdade de Ciências Farmacêuticas de Ribeirão Preto – USP, Av. do Café s/n, Ribeirão Preto-SP, 14040-903, Brazil
Faculdade de Ceilandia, Universidade de Brasília, Brasilia-DF, Brazil
Departamento de Química Inorgánica, Analítica y Química Física and INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina
Palabras clave:Antitumor agents; Nitrogen oxides; Ruthenium; Singlet oxygen; Toxicity
Año:2016
Volumen:2016
Número:22
Página de inicio:3592
Página de fin:3597
DOI: http://dx.doi.org/10.1002/ejic.201600217
Título revista:European Journal of Inorganic Chemistry
Título revista abreviado:Eur. J. Inorg. Chem.
ISSN:14341948
CODEN:EJICF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14341948_v2016_n22_p3592_Ramos

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Citas:

---------- APA ----------
Ramos, L.C.B., Marchesi, M.S.P., Callejon, D., Baruffi, M.D., Lunardi, C.N., Slep, L.D., Bendhack, L.M.,..., da Silva, R.S. (2016) . Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes. European Journal of Inorganic Chemistry, 2016(22), 3592-3597.
http://dx.doi.org/10.1002/ejic.201600217
---------- CHICAGO ----------
Ramos, L.C.B., Marchesi, M.S.P., Callejon, D., Baruffi, M.D., Lunardi, C.N., Slep, L.D., et al. "Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes" . European Journal of Inorganic Chemistry 2016, no. 22 (2016) : 3592-3597.
http://dx.doi.org/10.1002/ejic.201600217
---------- MLA ----------
Ramos, L.C.B., Marchesi, M.S.P., Callejon, D., Baruffi, M.D., Lunardi, C.N., Slep, L.D., et al. "Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes" . European Journal of Inorganic Chemistry, vol. 2016, no. 22, 2016, pp. 3592-3597.
http://dx.doi.org/10.1002/ejic.201600217
---------- VANCOUVER ----------
Ramos, L.C.B., Marchesi, M.S.P., Callejon, D., Baruffi, M.D., Lunardi, C.N., Slep, L.D., et al. Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes. Eur. J. Inorg. Chem. 2016;2016(22):3592-3597.
http://dx.doi.org/10.1002/ejic.201600217