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Mariño, K.; Marino, C.; Lima, C.; Baldoni, L.; De Lederkremer, R.M. "The first chemical synthesis of UDP[6-3H]-α-D- galactofuranose" (2005) European Journal of Organic Chemistry(14):2958-2964
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Abstract:

Galactofuranose metabolism is a good target for the development of novel chemotherapeutic agents for the treatment of some microbial infections. This is a valid objective because galactofuranose is absent in mammals. Two enzymes are involved in the biosynthesis of molecules containing galactofuranose: a mutase, which catalyzes the interconversion of UDP-Galp and UDP-Galf, and D-galactofuranosyltransferases. The mechanism of action of the mutase and its inhibition is currently being investigated, whereas studies on the galactofuranosyltransferases have been hampered by the lack of a labeled galactofuranose nucleotide. In the present work we describe the chemical synthesis of UDP-α-D-[6-3H]Galf and we prove its effectiveness for incorporation of radioactive galactofuranose into a natural acceptor. This is the first report on the chemical synthesis of a labeled donor of galactofuranose with the potential for studying the galactofuranosyltransferases independently from the UDP-Galp mutase. © Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Registro:

Documento: Artículo
Título:The first chemical synthesis of UDP[6-3H]-α-D- galactofuranose
Autor:Mariño, K.; Marino, C.; Lima, C.; Baldoni, L.; De Lederkremer, R.M.
Filiación:CIHIDECAR (CONICET), Departamento de Química Orgánica, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Carbohydrates; Galactofuranosyltransferase; Isotopic labeling; Nucleotides; UDP-Galf
Año:2005
Número:14
Página de inicio:2958
Página de fin:2964
DOI: http://dx.doi.org/10.1002/ejoc.200500056
Título revista:European Journal of Organic Chemistry
Título revista abreviado:Eur. J. Org. Chem.
ISSN:1434193X
CODEN:EJOCF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1434193X_v_n14_p2958_Marino

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Citas:

---------- APA ----------
Mariño, K., Marino, C., Lima, C., Baldoni, L. & De Lederkremer, R.M. (2005) . The first chemical synthesis of UDP[6-3H]-α-D- galactofuranose. European Journal of Organic Chemistry(14), 2958-2964.
http://dx.doi.org/10.1002/ejoc.200500056
---------- CHICAGO ----------
Mariño, K., Marino, C., Lima, C., Baldoni, L., De Lederkremer, R.M. "The first chemical synthesis of UDP[6-3H]-α-D- galactofuranose" . European Journal of Organic Chemistry, no. 14 (2005) : 2958-2964.
http://dx.doi.org/10.1002/ejoc.200500056
---------- MLA ----------
Mariño, K., Marino, C., Lima, C., Baldoni, L., De Lederkremer, R.M. "The first chemical synthesis of UDP[6-3H]-α-D- galactofuranose" . European Journal of Organic Chemistry, no. 14, 2005, pp. 2958-2964.
http://dx.doi.org/10.1002/ejoc.200500056
---------- VANCOUVER ----------
Mariño, K., Marino, C., Lima, C., Baldoni, L., De Lederkremer, R.M. The first chemical synthesis of UDP[6-3H]-α-D- galactofuranose. Eur. J. Org. Chem. 2005(14):2958-2964.
http://dx.doi.org/10.1002/ejoc.200500056