Abstract:
Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions. © 2011 by the authors.
Registro:
Documento: |
Artículo
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Título: | Epigenetics: New questions on the response to hypoxia |
Autor: | Perez-Perri, J.I.; Acevedo, J.M.; Wappner, P. |
Filiación: | Instituto Leloir, Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires C1033AAJ, Argentina Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina
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Palabras clave: | Chromatin; HIF; Histone; Jumonji; Oxygen; Stress; histone acetyltransferase; histone acetyltransferase PCAF; histone deacetylase; histone deacetylase 1; histone deacetylase 4; histone deacetylase 5; histone deacetylase 7; histone demethylase; hypoxia inducible factor; hypoxia inducible factor 1alpha; hypoxia inducible factor 2alpha; sirtuin 1; chromatin; histone; histone acetyltransferase; histone deacetylase; chromatin assembly and disassembly; chromatin structure; DNA methylation; epigenetics; gene activation; gene expression regulation; gene induction; gene repression; histone acetylation; histone methylation; histone modification; homeostasis; hypoxia; nonhuman; review; transcription initiation; animal; anoxia; chemistry; chromatin; genetics; human; metabolism; Mammalia; Animals; Anoxia; Chromatin; Epigenomics; Histone Acetyltransferases; Histone Deacetylases; Histones; Humans |
Año: | 2011
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Volumen: | 12
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Número: | 7
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Página de inicio: | 4705
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Página de fin: | 4721
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DOI: |
http://dx.doi.org/10.3390/ijms12074705 |
Título revista: | International Journal of Molecular Sciences
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Título revista abreviado: | Int. J. Mol. Sci.
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ISSN: | 14220067
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CAS: | histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; histone, 9062-68-4; histone acetyltransferase, 9054-51-7; histone deacetylase, 9076-57-7; Chromatin; Histone Acetyltransferases; Histone Deacetylases; Histones
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14220067_v12_n7_p4705_PerezPerri |
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Citas:
---------- APA ----------
Perez-Perri, J.I., Acevedo, J.M. & Wappner, P.
(2011)
. Epigenetics: New questions on the response to hypoxia. International Journal of Molecular Sciences, 12(7), 4705-4721.
http://dx.doi.org/10.3390/ijms12074705---------- CHICAGO ----------
Perez-Perri, J.I., Acevedo, J.M., Wappner, P.
"Epigenetics: New questions on the response to hypoxia"
. International Journal of Molecular Sciences 12, no. 7
(2011) : 4705-4721.
http://dx.doi.org/10.3390/ijms12074705---------- MLA ----------
Perez-Perri, J.I., Acevedo, J.M., Wappner, P.
"Epigenetics: New questions on the response to hypoxia"
. International Journal of Molecular Sciences, vol. 12, no. 7, 2011, pp. 4705-4721.
http://dx.doi.org/10.3390/ijms12074705---------- VANCOUVER ----------
Perez-Perri, J.I., Acevedo, J.M., Wappner, P. Epigenetics: New questions on the response to hypoxia. Int. J. Mol. Sci. 2011;12(7):4705-4721.
http://dx.doi.org/10.3390/ijms12074705