Artículo

Thomas, M.G.; Pascual, M.L.; Maschi, D.; Luchelli, L.; Boccaccio, G.L. "Synaptic control of local translation: The plot thickens with new characters" (2014) Cellular and Molecular Life Sciences. 71(12):2219-2239
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Abstract:

The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which includes thousands of messengers encoding multiple cellular functions. Translation is locally modulated by synaptic activity through a complex network of RNA-binding proteins (RBPs) and various types of non-coding RNAs (ncRNAs) including BC-RNAs, microRNAs, piwi-interacting RNAs, and small interference RNAs. The RBPs FMRP and CPEB play a well-established role in synaptic translation, and additional regulatory factors are emerging. The mRNA repressors Smaug, Nanos, and Pumilio define a novel pathway for local translational control that affects dendritic branching and spines in both flies and mammals. Recent findings support a role for processing bodies and related synaptic mRNA-silencing foci (SyAS-foci) in the modulation of synaptic plasticity and memory formation. The SyAS-foci respond to different stimuli with changes in their integrity thus enabling regulated mRNA release followed by translation. CPEB, Pumilio, TDP-43, and FUS/TLS form multimers through low-complexity regions related to prion domains or polyQ expansions. The oligomerization of these repressor RBPs is mechanistically linked to the aggregation of abnormal proteins commonly associated with neurodegeneration. Here, we summarize the current knowledge on how specificity in mRNA translation is achieved through the concerted action of multiple pathways that involve regulatory ncRNAs and RBPs, the modification of translation factors, and mRNA-silencing foci dynamics. © 2013 Springer Basel.

Registro:

Documento: Artículo
Título:Synaptic control of local translation: The plot thickens with new characters
Autor:Thomas, M.G.; Pascual, M.L.; Maschi, D.; Luchelli, L.; Boccaccio, G.L.
Filiación:Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina
IIBBA-CONICET, C1405BWE Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Buenos Aires, Argentina
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, United States
Palabras clave:Abnormal protein aggregation; ARC/Arg3.1; EJC; mTOR; NMDAR; Stress granules; brain derived neurotrophic factor; cytoplasmic polyadenylation element binding protein; fused in sarcoma protein; messenger RNA; microRNA; Piwi interacting RNA; RNA binding protein; small interfering RNA; TAR DNA binding protein; transcriptome; untranslated RNA; behavior; cell function; cognition; dendritic spine; gene silencing; human; molecular mechanics; nerve cell plasticity; nerve degeneration; oligomerization; protein aggregation; regulatory mechanism; repressor gene; review; RNA transport; synaptic potential; synaptic transmission; transcription regulation; Animals; Gene Expression Regulation; Humans; Protein Biosynthesis; Protein Transport; Synapses; Synaptic Transmission; Transcriptome
Año:2014
Volumen:71
Número:12
Página de inicio:2219
Página de fin:2239
DOI: http://dx.doi.org/10.1007/s00018-013-1506-y
Título revista:Cellular and Molecular Life Sciences
Título revista abreviado:Cell. Mol. Life Sci.
ISSN:1420682X
CODEN:CMLSF
CAS:brain derived neurotrophic factor, 218441-99-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1420682X_v71_n12_p2219_Thomas

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Citas:

---------- APA ----------
Thomas, M.G., Pascual, M.L., Maschi, D., Luchelli, L. & Boccaccio, G.L. (2014) . Synaptic control of local translation: The plot thickens with new characters. Cellular and Molecular Life Sciences, 71(12), 2219-2239.
http://dx.doi.org/10.1007/s00018-013-1506-y
---------- CHICAGO ----------
Thomas, M.G., Pascual, M.L., Maschi, D., Luchelli, L., Boccaccio, G.L. "Synaptic control of local translation: The plot thickens with new characters" . Cellular and Molecular Life Sciences 71, no. 12 (2014) : 2219-2239.
http://dx.doi.org/10.1007/s00018-013-1506-y
---------- MLA ----------
Thomas, M.G., Pascual, M.L., Maschi, D., Luchelli, L., Boccaccio, G.L. "Synaptic control of local translation: The plot thickens with new characters" . Cellular and Molecular Life Sciences, vol. 71, no. 12, 2014, pp. 2219-2239.
http://dx.doi.org/10.1007/s00018-013-1506-y
---------- VANCOUVER ----------
Thomas, M.G., Pascual, M.L., Maschi, D., Luchelli, L., Boccaccio, G.L. Synaptic control of local translation: The plot thickens with new characters. Cell. Mol. Life Sci. 2014;71(12):2219-2239.
http://dx.doi.org/10.1007/s00018-013-1506-y