Artículo

Albrecht, M.; Frungieri, M.B.; Kunz, L.; Rämsch, R.; Meineke, V.; Köhn, F.M.; Mayerhofer, A. "Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour" (2005) Cellular and Molecular Life Sciences. 62(23):2867-2876
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Abstract:

Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. © Birkhäuser Verlag, 2005.

Registro:

Documento: Artículo
Título:Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour
Autor:Albrecht, M.; Frungieri, M.B.; Kunz, L.; Rämsch, R.; Meineke, V.; Köhn, F.M.; Mayerhofer, A.
Filiación:Institute of Anatomy, Ludwig-Maximilians-University, Biedersteiner Strasse 29, 80802 Munich, Germany
Institute of Biology and Experimental Medicine, CONICET, 1428 Buenos Aires, Argentina
Institute of Radiobiology, Sanitätsakademie der Bundeswehr, Neuherbergstrasse 11, 80937 Munich, Germany
Department of Dermatology and Allergy, Technical University, Biedersteiner Strasse 29, 80802 Munich, Germany
Palabras clave:Calcium; Histamine; Mast cell; Proliferation; Tissue remodeling; TNF-alpha; Tryptase; calcium ion; histamine; proteinase activated receptor 2; tryptase; tumor necrosis factor alpha; tumor necrosis factor receptor 1; tumor necrosis factor receptor 2; article; calcium cell level; cell cycle; cell proliferation; cell stimulation; controlled study; fetus; fibroblast; gene expression; human; human cell; immunohistochemistry; mast cell; polymerase chain reaction; protein expression; skin fibroblast; Cell Cycle; Cell Proliferation; Cells, Cultured; Fibroblasts; Gene Expression; Histamine; Humans; Mast Cells; Peptides; Receptor, PAR-2; Reference Values; Serine Endopeptidases; Skin; Time Factors; Tryptases; Tumor Necrosis Factor-alpha
Año:2005
Volumen:62
Número:23
Página de inicio:2867
Página de fin:2876
DOI: http://dx.doi.org/10.1007/s00018-005-5289-7
Título revista:Cellular and Molecular Life Sciences
Título revista abreviado:Cell. Mol. Life Sci.
ISSN:1420682X
CODEN:CMLSF
CAS:calcium ion, 14127-61-8; histamine, 51-45-6, 56-92-8, 93443-21-1; tryptase, 97501-93-4; Histamine, 51-45-6; Peptides; Receptor, PAR-2; Serine Endopeptidases, EC 3.4.21.-; Tryptases, EC 3.4.21.59; Tumor Necrosis Factor-alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1420682X_v62_n23_p2867_Albrecht

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Citas:

---------- APA ----------
Albrecht, M., Frungieri, M.B., Kunz, L., Rämsch, R., Meineke, V., Köhn, F.M. & Mayerhofer, A. (2005) . Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour. Cellular and Molecular Life Sciences, 62(23), 2867-2876.
http://dx.doi.org/10.1007/s00018-005-5289-7
---------- CHICAGO ----------
Albrecht, M., Frungieri, M.B., Kunz, L., Rämsch, R., Meineke, V., Köhn, F.M., et al. "Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour" . Cellular and Molecular Life Sciences 62, no. 23 (2005) : 2867-2876.
http://dx.doi.org/10.1007/s00018-005-5289-7
---------- MLA ----------
Albrecht, M., Frungieri, M.B., Kunz, L., Rämsch, R., Meineke, V., Köhn, F.M., et al. "Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour" . Cellular and Molecular Life Sciences, vol. 62, no. 23, 2005, pp. 2867-2876.
http://dx.doi.org/10.1007/s00018-005-5289-7
---------- VANCOUVER ----------
Albrecht, M., Frungieri, M.B., Kunz, L., Rämsch, R., Meineke, V., Köhn, F.M., et al. Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour. Cell. Mol. Life Sci. 2005;62(23):2867-2876.
http://dx.doi.org/10.1007/s00018-005-5289-7