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Abstract:

The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallanetype triterpene, 3-α-tigloylmelianol (1) and three known tirucallanes, melianone (2), 21-β-acetoxy-melianone (3), and methyl kulonate (4). The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as HPLC-Q-TOF mass spectrometry. The cytotoxicity of the isolated compounds toward the human lung adenocarcinoma epithelial cell line A549 was determined, while no activity was observed against the phytonematode Meloidogyne incognita. © 2010 by the authors.

Registro:

Documento: Artículo
Título:Cytotoxic tirucallane triterpenoids from Melia azedarach fruits
Autor:Ntalli, N.G.; Cottiglia, F.; Bueno, C.A.; Alché, L.E.; Leonti, M.; Vargiu, S.; Bifulco, E.; Menkissoglu-Spiroudi, U.; Caboni, P.
Filiación:Pesticide Science Laboratory, Faculty of Agriculture, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 4to. Piso, Ciudad Universitaria, Buenos Aires, Argentina
Department of Toxicology, Università degli Studi di Cagliari, via Ospedale 72, 09124 Cagliari, Italy
Palabras clave:21-β-Acetoxy- melianone; 3-α-Tigloylmelianol; Cytotoxicity; Melianone; Methyl kulonate; cytotoxin; plant extract; tirucallane; triterpene; adenocarcinoma; animal; article; chemical structure; chemistry; drug effect; epithelium cell; fruit; human; isolation and purification; lung tumor; Melia azedarach; nematode; pathology; tumor cell line; Adenocarcinoma; Animals; Cell Line, Tumor; Cytotoxins; Epithelial Cells; Fruit; Humans; Lung Neoplasms; Melia azedarach; Molecular Structure; Plant Extracts; Triterpenes; Tylenchoidea
Año:2010
Volumen:15
Número:9
Página de inicio:5866
Página de fin:5877
DOI: http://dx.doi.org/10.3390/molecules15095866
Título revista:Molecules
Título revista abreviado:Molecules
ISSN:14203049
CODEN:MOLEF
CAS:Cytotoxins; Plant Extracts; Triterpenes; tirucallane
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_14203049_v15_n9_p5866_Ntalli.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14203049_v15_n9_p5866_Ntalli

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Citas:

---------- APA ----------
Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., Bifulco, E.,..., Caboni, P. (2010) . Cytotoxic tirucallane triterpenoids from Melia azedarach fruits. Molecules, 15(9), 5866-5877.
http://dx.doi.org/10.3390/molecules15095866
---------- CHICAGO ----------
Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., et al. "Cytotoxic tirucallane triterpenoids from Melia azedarach fruits" . Molecules 15, no. 9 (2010) : 5866-5877.
http://dx.doi.org/10.3390/molecules15095866
---------- MLA ----------
Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., et al. "Cytotoxic tirucallane triterpenoids from Melia azedarach fruits" . Molecules, vol. 15, no. 9, 2010, pp. 5866-5877.
http://dx.doi.org/10.3390/molecules15095866
---------- VANCOUVER ----------
Ntalli, N.G., Cottiglia, F., Bueno, C.A., Alché, L.E., Leonti, M., Vargiu, S., et al. Cytotoxic tirucallane triterpenoids from Melia azedarach fruits. Molecules. 2010;15(9):5866-5877.
http://dx.doi.org/10.3390/molecules15095866