Artículo

Coelho, C.; Figueiredo, R.; Frank, E.; Burger, J.; Schecklmann, M.; Landgrebe, M.; Langguth, B.; Elgoyhen, A.B. "Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study" (2012) Audiology and Neurotology. 17(3):179-188
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Abstract:

Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials. Copyright © 2012 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study
Autor:Coelho, C.; Figueiredo, R.; Frank, E.; Burger, J.; Schecklmann, M.; Landgrebe, M.; Langguth, B.; Elgoyhen, A.B.
Filiación:Department of Otolaryngoly and Head and Neck Surgery, University of Iowa, Iowa City, IA, United States
Grupo de Pesquisa em Otoneurologia, Departamento de Otorrinolaringologia, Universidade Federal do Rio Grande do sul, Porto Alegre, Brazil
OTOSUL, Clinical and Research Tinnitus Center, Volta Redonda, Brazil
Interdisciplinary Tinnitus Clinic, Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Muscle relaxants; Phantom perception; Somatosensory system; Tinnitus; amitriptyline; central muscle relaxant; clonidine; cyclobenzaprine; drug derivative; eperisone; orphenadrine; propiophenone derivative; tizanidine; adult; aged; article; clinical trial; female; hospitalization; human; male; middle aged; pilot study; tinnitus; treatment outcome; Adult; Aged; Amitriptyline; Clonidine; Female; Humans; Male; Middle Aged; Muscle Relaxants, Central; Orphenadrine; Pilot Projects; Propiophenones; Severity of Illness Index; Tinnitus; Treatment Outcome
Año:2012
Volumen:17
Número:3
Página de inicio:179
Página de fin:188
DOI: http://dx.doi.org/10.1159/000335657
Título revista:Audiology and Neurotology
Título revista abreviado:Audiol. Neurotol.
ISSN:14203030
CAS:amitriptyline, 50-48-6, 549-18-8; clonidine, 4205-90-7, 4205-91-8, 57066-25-8; cyclobenzaprine, 303-53-7, 6202-23-9; eperisone, 56839-43-1, 64840-90-0; orphenadrine, 341-69-5, 83-98-7; tizanidine, 51322-75-9, 64461-82-1; Amitriptyline, 50-48-6; Clonidine, 4205-90-7; Muscle Relaxants, Central; Orphenadrine, 83-98-7; Propiophenones; cyclobenzaprine, 303-53-7; eperisone, 56839-43-1; tizanidine, 51322-75-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14203030_v17_n3_p179_Coelho

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Citas:

---------- APA ----------
Coelho, C., Figueiredo, R., Frank, E., Burger, J., Schecklmann, M., Landgrebe, M., Langguth, B.,..., Elgoyhen, A.B. (2012) . Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study. Audiology and Neurotology, 17(3), 179-188.
http://dx.doi.org/10.1159/000335657
---------- CHICAGO ----------
Coelho, C., Figueiredo, R., Frank, E., Burger, J., Schecklmann, M., Landgrebe, M., et al. "Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study" . Audiology and Neurotology 17, no. 3 (2012) : 179-188.
http://dx.doi.org/10.1159/000335657
---------- MLA ----------
Coelho, C., Figueiredo, R., Frank, E., Burger, J., Schecklmann, M., Landgrebe, M., et al. "Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study" . Audiology and Neurotology, vol. 17, no. 3, 2012, pp. 179-188.
http://dx.doi.org/10.1159/000335657
---------- VANCOUVER ----------
Coelho, C., Figueiredo, R., Frank, E., Burger, J., Schecklmann, M., Landgrebe, M., et al. Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study. Audiol. Neurotol. 2012;17(3):179-188.
http://dx.doi.org/10.1159/000335657