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Abstract:

The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice. The mice in the experimental group (n=32) were injected intraperitoneally with 133 mg kg-1 of metronidazole parenteral solution and the control group consisted of mice (n=36) which had not been injected with metronidazole. There was no significant difference (p > 0.05) between the sexes regarding the micronucleus frequency in either the experimental or the control group. When the Mn frequencies of the three strains were compared, the results for the CFW and BALB/cJ strains did not differ statistically (p > 0.05) for either the experimental or control groups but there were significant (p < 0.05) differences between the CFW and NIH strains and the NIH and BALB/cJ strains for the experimental and control groups, with the NIH strain always showing the highest micronucleus frequency. Our results also show that metronidazole was possible genotoxic agent because it produced a significant increase (p < 0.05) in the micronucleus frequency of the experimental group as compared to the control group for all the three mouse strains tested. Copyright by the Brazilian Society of Genetics.

Registro:

Documento: Artículo
Título:The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
Autor:Abrevaya, X.C.; Carballo, M.A.; Mudry, M.D.
Filiación:Grupo de Investigación en Biología Evolutiva, Departamento de Ecología Genética y Evolución, Universidad de Buenos Aires, Pabellón II, Buenos Aires, Argentina
Citogenética Humana y Genética Toxicológica, Departmento de Bioquímica Clínica, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:BALB/cJ; Bone marrow micronucleus test; CFW; Genotoxicity; Metronidazole; NIH; metronidazole; animal experiment; animal model; animal tissue; article; Bagg albino mouse; bone marrow; controlled study; drug exposure; female; genetic toxicology; genotoxicity; inbred strain; male; micronucleus test; mouse; mouse strain; nonhuman; outbred strain; sex difference; statistical significance; strain difference; Swiss Webster mouse; toxicity testing; Mus; Mus musculus
Año:2007
Volumen:30
Número:4
Página de inicio:1139
Página de fin:1143
DOI: http://dx.doi.org/10.1590/S1415-47572007000600018
Título revista:Genetics and Molecular Biology
Título revista abreviado:Genet. Mol. Biol.
ISSN:14154757
CODEN:GMBIF
CAS:metronidazole, 39322-38-8, 443-48-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14154757_v30_n4_p1139_Abrevaya

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Citas:

---------- APA ----------
Abrevaya, X.C., Carballo, M.A. & Mudry, M.D. (2007) . The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus). Genetics and Molecular Biology, 30(4), 1139-1143.
http://dx.doi.org/10.1590/S1415-47572007000600018
---------- CHICAGO ----------
Abrevaya, X.C., Carballo, M.A., Mudry, M.D. "The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)" . Genetics and Molecular Biology 30, no. 4 (2007) : 1139-1143.
http://dx.doi.org/10.1590/S1415-47572007000600018
---------- MLA ----------
Abrevaya, X.C., Carballo, M.A., Mudry, M.D. "The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)" . Genetics and Molecular Biology, vol. 30, no. 4, 2007, pp. 1139-1143.
http://dx.doi.org/10.1590/S1415-47572007000600018
---------- VANCOUVER ----------
Abrevaya, X.C., Carballo, M.A., Mudry, M.D. The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus). Genet. Mol. Biol. 2007;30(4):1139-1143.
http://dx.doi.org/10.1590/S1415-47572007000600018