Artículo

Peltoketo, H.; Zhang, F.-P.; Rulli, S.B. "Animal models for aberrations of gonadotropin action" (2011) Reviews in Endocrine and Metabolic Disorders. 12(4):245-258
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Abstract:

During the last two decades a large number of genetically modified mouse lines with altered gonadotropin action have been generated. These mouse lines fall into three categories: the lack-of-function mice, gain-of-function mice, and the mice generated by breeding the abovementioned lines with other disease model lines. The mouse strains lacking gonadotropin action have elucidated the necessity of the pituitary hormones in pubertal development and function of gonads, and revealed the processes from the original genetic defect to the pathological phenotype such as hypo- or hypergonadotropic hypogonadism. Conversely, the strains of the second group depict consequences of chronic gonadotropin action. The lines vary from those expressing constitutively active receptors and those secreting follicle-stimulating hormone (FSH) with slowly increasing amounts to those producing human choriogonadotropin (hCG), amount of which corresponds to 2000-fold luteinizing hormone (LH)/hCG biological activity. Accordingly, the phenotypes diverge from mild anomalies and enhanced fertility to disrupted gametogenesis, but eventually chronic, enhanced and non-pulsatile action of both FSH and LH leads to female and male infertility and/or hyper- and neoplasias in most of the gonadotropin gain-offunction mice. Elevated gonadotropin levels also alter the function of several extra-gonadal tissues either directly or indirectly via increased sex steroid production. These effects include promotion of tumorigenesis in tissues such as the pituitary, mammary and adrenal glands. Finally, the crossbreedings of the current mouse strains with other disease models are likely to uncover the contribution of gonadotropins in novel biological systems, as exemplified by the recent crossbreed of LHCG receptor deficient mice with Alzheimer disease mice. © Springer Science+Business Media, LLC 2011.

Registro:

Documento: Artículo
Título:Animal models for aberrations of gonadotropin action
Autor:Peltoketo, H.; Zhang, F.-P.; Rulli, S.B.
Filiación:Institute of Reproductive and Developmental Biology, Imperial College London, DuCane Road, London W12 0NN, United Kingdom
Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland
Instituto de Biología y Medicina Experimental-CONICET, Vuelta de Obligado 2490 (1428), Buenos Aires, Argentina
Palabras clave:Gonadotropin; Ovary. Testis; Pituitary. Genetically modified; Receptor; chorionic gonadotropin; follitropin; gonadotropin; hypophysis hormone; luteinizing hormone; article; carcinogenesis; disease model; genetic disorder; hypergonadotropic hypogonadism; hypogonadotropic hypogonadism; hypophysis; hypothalamus hypophysis gonad system; male accessory gland; nonhuman; ovary; ovary follicle; phenotype; testis; urogenital system; Animals; Disease Models, Animal; Endocrine System Diseases; Female; Gonadotropins; Humans; Male; Mice; Mice, Transgenic; Ovary; Pituitary Gland; Testis
Año:2011
Volumen:12
Número:4
Página de inicio:245
Página de fin:258
DOI: http://dx.doi.org/10.1007/s11154-011-9174-4
Título revista:Reviews in Endocrine and Metabolic Disorders
Título revista abreviado:Rev. Endocr. Metab. Disord.
ISSN:13899155
CODEN:REMDC
CAS:chorionic gonadotropin, 9002-61-3; follitropin, 9002-68-0; gonadotropin, 63231-54-9; hypophysis hormone, 85883-81-4; luteinizing hormone, 39341-83-8, 9002-67-9; Gonadotropins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13899155_v12_n4_p245_Peltoketo

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Citas:

---------- APA ----------
Peltoketo, H., Zhang, F.-P. & Rulli, S.B. (2011) . Animal models for aberrations of gonadotropin action. Reviews in Endocrine and Metabolic Disorders, 12(4), 245-258.
http://dx.doi.org/10.1007/s11154-011-9174-4
---------- CHICAGO ----------
Peltoketo, H., Zhang, F.-P., Rulli, S.B. "Animal models for aberrations of gonadotropin action" . Reviews in Endocrine and Metabolic Disorders 12, no. 4 (2011) : 245-258.
http://dx.doi.org/10.1007/s11154-011-9174-4
---------- MLA ----------
Peltoketo, H., Zhang, F.-P., Rulli, S.B. "Animal models for aberrations of gonadotropin action" . Reviews in Endocrine and Metabolic Disorders, vol. 12, no. 4, 2011, pp. 245-258.
http://dx.doi.org/10.1007/s11154-011-9174-4
---------- VANCOUVER ----------
Peltoketo, H., Zhang, F.-P., Rulli, S.B. Animal models for aberrations of gonadotropin action. Rev. Endocr. Metab. Disord. 2011;12(4):245-258.
http://dx.doi.org/10.1007/s11154-011-9174-4