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Abstract:

An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of Drosophila melanogaster subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype. © 2016, Springer Science+Business Media Dordrecht.

Registro:

Documento: Artículo
Título:Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life
Autor:Gomez, F.H.; Sambucetti, P.; Norry, F.M.
Filiación:Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires – IEGEBA (CONICET-UBA), Buenos Aires, C-1428-EHA, Argentina
Palabras clave:Heat-shock stress; Hormesis; Lifespan; Quantitative trait locus (QTL); adult; Article; chromosome 2; controlled study; Drosophila melanogaster; female; genotype; heat stress; heat treatment; hormesis; life extension; lifespan; longevity; male; nonhuman; priority journal; quantitative trait locus; recombinant inbred strain; sex difference; aging; animal; Drosophila melanogaster; gene expression regulation; genetic recombination; genetics; heat shock response; heat tolerance; inbred strain; longevity; sexual development; Drosophila protein; Aging; Animals; Animals, Inbred Strains; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression Regulation, Developmental; Heat-Shock Response; Hormesis; Longevity; Male; Quantitative Trait Loci; Recombination, Genetic; Sex Characteristics; Thermotolerance
Año:2016
Volumen:17
Número:5-6
Página de inicio:883
Página de fin:892
DOI: http://dx.doi.org/10.1007/s10522-016-9658-4
Título revista:Biogerontology
Título revista abreviado:Biogerontology
ISSN:13895729
CODEN:BIOGC
CAS:Drosophila Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895729_v17_n5-6_p883_Gomez

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Citas:

---------- APA ----------
Gomez, F.H., Sambucetti, P. & Norry, F.M. (2016) . Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life. Biogerontology, 17(5-6), 883-892.
http://dx.doi.org/10.1007/s10522-016-9658-4
---------- CHICAGO ----------
Gomez, F.H., Sambucetti, P., Norry, F.M. "Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life" . Biogerontology 17, no. 5-6 (2016) : 883-892.
http://dx.doi.org/10.1007/s10522-016-9658-4
---------- MLA ----------
Gomez, F.H., Sambucetti, P., Norry, F.M. "Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life" . Biogerontology, vol. 17, no. 5-6, 2016, pp. 883-892.
http://dx.doi.org/10.1007/s10522-016-9658-4
---------- VANCOUVER ----------
Gomez, F.H., Sambucetti, P., Norry, F.M. Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life. Biogerontology. 2016;17(5-6):883-892.
http://dx.doi.org/10.1007/s10522-016-9658-4