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Abstract:

Quantitative trait loci (QTL) were mapped for longevity and fecundity at two temperatures, 20 and 30 °C, in two sets of recombinant inbred lines (RIL) highly differing in thermotolerance. Early fecundity (EF) and longevity showed a negative association between temperatures. For instance, longevity was higher and fecundity was lower in the RIL panel showing higher life span at 30 °C. One X-linked QTL (7B3-12E) co-localized for longevity and EF at 20 °C, with one QTL allele showing a positive additive effect on longevity and a negative effect on EF. The across-RIL genetic correlation between longevity and EF was not significant within each temperature, and most QTL that affect life span have no effect on EF at each temperature. EF and longevity can mostly be genetically uncoupled in the thermotolerance-divergent RIL within each temperature as opposed to between temperatures. QTL were mostly temperature specific, although some trait-specific QTL showed possible antagonistic effects between temperatures. © 2015, Springer Science+Business Media Dordrecht.

Registro:

Documento: Artículo
Título:Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster
Autor:Sambucetti, P.; Loeschcke, V.; Norry, F.M.
Filiación:Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires - IEGEBA (CONICET-UBA), C-1428-EHA, Buenos Aires, Argentina
Department of Bioscience, Aarhus University, Ny Munkegade 114, Building 1540, Aarhus C, 8000, Denmark
Palabras clave:Antagonistic pleiotropy; Early fecundity; Quantitative trait loci (QTL); Senescence; Temperature-specific QTL; adult; animal experiment; antagonistic pleiotropy; Article; controlled study; Drosophila melanogaster; epistasis; female; fertility; genetic association; genetic correlation; genotype; heat tolerance; lifespan; longevity; male; nonhuman; pleiotropy; priority journal; quantitative trait locus mapping; recombinant inbred strain; temperature sensitivity; animal; chromosomal mapping; Drosophila melanogaster; fertility; genetic recombination; genetics; heat; longevity; phenotype; physiology; quantitative trait locus; temperature; Animals; Chromosome Mapping; Drosophila melanogaster; Female; Fertility; Hot Temperature; Longevity; Male; Phenotype; Quantitative Trait Loci; Recombination, Genetic; Temperature
Año:2015
Volumen:16
Número:6
Página de inicio:801
Página de fin:810
DOI: http://dx.doi.org/10.1007/s10522-015-9606-8
Título revista:Biogerontology
Título revista abreviado:Biogerontology
ISSN:13895729
CODEN:BIOGC
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895729_v16_n6_p801_Sambucetti

Referencias:

  • Arias, L.N., Sambucetti, P., Scannapieco, A.C., Loeschcke, V., Norry, F.M., Survival of heat stress with and without heat hardening in Drosophila melanogaster: interactions with larval density (2012) J Exp Biol, 215, pp. 2220-2225. , COI: 1:CAS:528:DC%2BC38Xhtlagtb7E, PID: 22675182
  • Bates, D., Maechler, M., Bolker, B., Walker S (2013) lme4: linear mixed-effects models using Eigen and S4 R Package version, 1, pp. 0-5. , http://CRAN.R-project.org/package=lme4
  • Bergland, A.O., Chae, H., Kim, Y., Tatar, M., Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin (2012) PLoS Genet, 8, p. 4
  • Curtsinger, J.W., Khazaeli, A.A., Lifespan, QTLs, age-specificity, and pleiotropy in Drosophila (2002) Mech Ageing Dev, 123, pp. 81-93. , PID: 11718803
  • Defays, R., Gomez, F., Sambucetti, P., Scannapieco, A., Loeschcke, V., Norry, F., Quantitative trait loci for longevity in heat-stressed Drosophila melanogaster (2011) Exp Gerontol, 46, pp. 819-826. , COI: 1:CAS:528:DC%2BC3MXhtFektbzL, PID: 21798333
  • Di Rienzo, J.A., Casanoves, F., Balzarini, M.G., Gonzalez, L., Tablada, M., Robledo, C.W., InfoStat versión 2014. Grupo InfoStat (2014) FCA, , http://www.infostat.com.ar, Universidad Nacional de Córdoba, Argentina
  • Dupuis, J., Siegmund, D., Statistical methods for mapping quantitative trait loci from a dense set of markers (1999) Genetics, 151, pp. 373-386. , COI: 1:STN:280:DyaK1M%2FptFGksQ%3D%3D, PID: 9872974
  • Flatt, T., Survival costs of reproduction in Drosophila (2011) Exp Gerontol, 46, pp. 369-375. , PID: 20970491
  • Flatt, T., Promislow, D.E.L., Still pondering an age-old question (2007) Science, 318, pp. 1255-1256. , COI: 1:CAS:528:DC%2BD2sXhtlOmtr7F, PID: 18033874
  • Gagnon, A., Natural fertility and longevity (2015) Fertil Steril, 103, pp. 1109-1116. , PID: 25934597
  • Huey, R.B., Wakefield, T., Crill, W.D., Gilchrist, G.W., Within and between generation effects of temperature on early fecundity of Drosophila melanogaster (1995) Heredity, 74, pp. 216-223. , PID: 7706111
  • Kengeri, S.S., Maras, A.H., Suckow, C.L., Chiang, E.C., Waters, D.J., Exceptional longevity in female Rottweiler dogs is not encumbered by investment in reproduction (2013) Age, 35, pp. 2503-2513. , COI: 1:STN:280:DC%2BC3srltVarsA%3D%3D, PID: 23584889
  • Khazaeli, A.A., Curtsinger, J.W., Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity (2013) J Gerontol A Biol Sci Med Sci, 68, pp. 546-553. , COI: 1:CAS:528:DC%2BC3sXmt1Sjtro%3D, PID: 23160365
  • Kimber, C.M., Chippindale, A.K., Mutation, condition, and the maintenance of extended lifespan in Drosophila (2013) Curr Biol, 23, pp. 2283-2287. , COI: 1:CAS:528:DC%2BC3sXhslClsb7J, PID: 24210612
  • Kirkwood, T.B., Evolution of ageing (1977) Nature, 270, pp. 301-304. , COI: 1:STN:280:DyaE1c%2FntFOhtQ%3D%3D, PID: 593350
  • Kirkwood, T.B., Austad, S.N., Why do we age? (2000) Nature, 408, pp. 233-238. , COI: 1:CAS:528:DC%2BD3cXotFGltL0%3D, PID: 11089980
  • Klepsatel, P., Gáliková, M., De Maio, N., Huber, C.D., Schlötterer, C., Flatt, T., Variation in thermal performance and reaction norms among populations of Drosophila melanogaster (2013) Evolution, 67, pp. 3573-3587. , PID: 24299409
  • Le Bourg, E., Does reproduction decrease longevity in human beings? (2007) Ageing Res Rev, 6, pp. 141-149. , PID: 17532269
  • Leips, J., Mackay, T.F.C., Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density (2000) Genetics, 155, pp. 1773-1788. , COI: 1:CAS:528:DC%2BD3cXmtFGqu7k%3D, PID: 10924473
  • Leips, J., Gilligan, P., Mackay, T.F.C., Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster (2006) Genetics, 172, pp. 1595-1605. , COI: 1:CAS:528:DC%2BD28XjvV2lt7g%3D, PID: 16272414
  • Leroi, A.M., Bartke, A., Benedictis, G.D., Franceschi, C., Gartner, A., Gonos, E., Feder, M.E., Kartal-Ozer, N., What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (2005) Mech Ageing Dev, 126, pp. 421-429. , COI: 1:CAS:528:DC%2BD2MXms1yjsQ%3D%3D, PID: 15664630
  • Luckinbill, L.S., Arking, R., Clare, M.J., Cirocco, W.C., Buck, S.A., Selection for delayed senescence in Drosophila melanogaster (1984) Evolution, 38, pp. 996-1003
  • Lynch, M., Walsh, B., (1998) Genetics and analysis of quantitative traits, , Sinauer Associates Inc, Sunderland
  • Mackay, T.F.C., Quantitative trait loci in Drosophila (2001) Nat Rev Genet, 2, pp. 11-20. , COI: 1:CAS:528:DC%2BD3MXisVGjs7w%3D, PID: 11253063
  • Mackay, T.F.C., The nature of quantitative genetic variation for Drosophila longevity (2002) Mech Ageing Dev, 123, pp. 95-104. , PID: 11718804
  • Medawar, P.B., (1952) An unsolved problem in biology, , Lewis, London
  • Morgan, T.J., Mackay, T.F.C., Quantitative trait loci for thermotolerance phenotypes in Drosophila melanogaster (2006) Heredity, 96, pp. 232-242. , COI: 1:CAS:528:DC%2BD28Xhs1Kisbg%3D, PID: 16404413
  • Norry, F.M., Sambucetti, P., Scannapieco, A.C., Loeschcke, V., Altitudinal patterns for longevity, fecundity and senescence in Drosophila buzzatii (2006) Heredity, 96, pp. 232-242
  • Norry, F.M., Scannapieco, A.C., Sambucetti, P., Bertoli, C.I., Loeschcke, V., Quantitative trait loci for heat-hardening acclimation, knockdown resistance to heat and chill-coma recovery in an intercontinental set of recombinant inbred lines of Drosophila melanogaster (2008) Mol Ecol, 17, pp. 4570-4581. , COI: 1:CAS:528:DC%2BD1cXhsVGgtL%2FK, PID: 18986501
  • Nuzhdin, S.V., Pasyukova, E.G., Dilda, C.L., Zeng, Z.-B., Mackay, T.F.C., Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster (1997) Proc Natl Acad Sci USA, 94, pp. 9734-9739. , COI: 1:CAS:528:DyaK2sXlvVWisL0%3D, PID: 9275193
  • Nuzhdin, S.V., Khazaeli, A.A., Curtsinger, J.W., Survival analysis of life span quantitative trait loci in Drosophila melanogaster (2005) Genetics, 170, pp. 718-731
  • Partridge, L., Gems, D., Withers, D.J., Sex and death: what is the connection? (2005) Cell, 120, pp. 461-472. , COI: 1:CAS:528:DC%2BD2MXitVWnur8%3D, PID: 15734679
  • Pasyukova, E.G., Roshina, N.V., Mackay, T.F.C., Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan (2004) Aging Cell, 5, pp. 297-307
  • (2014) R: A language and environment for statistical computing, , R Foundation for Statistical Computing, Vienna
  • Remolina, S.C., Chang, P.L., Leips, J., Nuzhdin, S.V., Hughes, K.A., Genomic basis of aging and life-history evolution in Drosophila melanogaster (2012) Evolution, 66, pp. 3390-3403. , PID: 23106705
  • Rose, M.R., Laboratory evolution of postponed senescence in Drosophila melanogaster (1984) Evolution, 38, pp. 1004-1010
  • Rose, M.R., (1991) Evolutionary biology of aging, , Oxford University Press, New York
  • Rose, M.R., Charlesworth, B., A test of evolutionary theories of senescence (1980) Nature, 287, pp. 141-142. , COI: 1:STN:280:DyaL3M%2Flt1aksg%3D%3D, PID: 6776406
  • Sambucetti, P., Sørensen, J.G., Loeschcke, V., Norry, F.M., Variation in senescence and associated traits between sympatric cactophilic sibling species of Drosophila (2005) Evol Ecol Res, 7, pp. 915-930
  • Sambucetti, P., Scannapieco, A.C., Loeschcke, V., Norry, F.M., Heat-stress survival in the pre-adult stage of the life cycle in an intercontinental set of recombinant inbred lines of Drosophila melanogaster (2013) J Exp Biol, 216, pp. 2953-2959. , COI: 1:STN:280:DC%2BC3srksF2itw%3D%3D, PID: 23580721
  • Scannapieco, A., Sambucetti, P., Norry, F.M., Direct and correlated responses to selection for longevity in Drosophila buzzatii (2009) Biol J Linn Soc Lond, 97, pp. 738-748
  • Service, P.M., Hutchison, E.W., Rose, M.R., Multiple genetic mechanisms for the evolution of senescence in Drosophila melanogaster (1988) Evolution, 42, pp. 708-716
  • Sørensen, J.G., Nielsen, M.M., Loeschcke, V., Gene expression profile analysis of Drosophila melanogaster selected for resistance to environmental stressors (2007) J Evol Biol, 20, pp. 1624-1636. , PID: 17584255
  • Tarin, J.J., Gómez-Piquer, V., García-Palomares, S., García-Pérez, M.A., Cano, A., Absence of long-term effects of reproduction on longevity in the mouse model (2014) Reprod Biol Endocrinol, 12, p. 84. , PID: 25159296
  • Tower, J., Heat shock proteins and Drosophila aging (2011) Exp Gerontol, 46, pp. 355-362. , COI: 1:CAS:528:DC%2BC3MXkvVWhs7c%3D, PID: 20840862
  • Vieira, C., Pasyukova, E.G., Zeng, Z.B., Hackett, J.B., Lyman, R.F., Mackay, T.F.C., HGenotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster (2000) Genetics, 154, pp. 213-227. , COI: 1:STN:280:DC%2BD3c%2FpsVOltg%3D%3D, PID: 10628982
  • Wang, S., Basten, C.J., Zeng, Z.B., Windows QTL Cartographer 2.5 (2010) Department of Statistics, , North Carolina State University, Raleigh
  • Williams, G.C., Natural selection, the costs of reproduction and a refinement of Lack’s principle (1966) Am Nat, 100, pp. 687-690
  • Wit, J., Sarup, P., Lupsa, N., Malte, H., Frydenberg, J., Loeschcke, V., Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span (2013) Exp Gerontol, 48, pp. 349-357. , PID: 23353929
  • Zeng, Z.B., Precision mapping of quantitative trait loci (1994) Genetics, 136, pp. 1457-1468. , COI: 1:CAS:528:DyaK2MXhtFantw%3D%3D, PID: 8013918
  • Zwaan, B., Bijlsma, R., Hoekstra, R., Direct selection on life span in Drosophila melanogaster (1995) Evolution, 49, pp. 649-659

Citas:

---------- APA ----------
Sambucetti, P., Loeschcke, V. & Norry, F.M. (2015) . Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster. Biogerontology, 16(6), 801-810.
http://dx.doi.org/10.1007/s10522-015-9606-8
---------- CHICAGO ----------
Sambucetti, P., Loeschcke, V., Norry, F.M. "Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster" . Biogerontology 16, no. 6 (2015) : 801-810.
http://dx.doi.org/10.1007/s10522-015-9606-8
---------- MLA ----------
Sambucetti, P., Loeschcke, V., Norry, F.M. "Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster" . Biogerontology, vol. 16, no. 6, 2015, pp. 801-810.
http://dx.doi.org/10.1007/s10522-015-9606-8
---------- VANCOUVER ----------
Sambucetti, P., Loeschcke, V., Norry, F.M. Patterns of longevity and fecundity at two temperatures in a set of heat-selected recombinant inbred lines of Drosophila melanogaster. Biogerontology. 2015;16(6):801-810.
http://dx.doi.org/10.1007/s10522-015-9606-8