Artículo

Martínez-Ceron, M.C.; Giudicessi, S.L.; Saavedra, S.L.; Gurevich-Messina, J.M.; Erra-Balsells, R.; Albericio, F.; Cascone, O.; Camperi, S.A. "Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries" (2016) Current Pharmaceutical Biotechnology. 17(5):449-457
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Abstract:

Solid phase screenings of one bead one compound (OBOC) libraries have been widely used to find ligands with pharmacological and analytical uses, and to purify or detect proteins in complex mixtures. To improve library screening, in the last years various strategies have been developed to avoid the selection of false positive beads and to obtain selective ligands. Currently, there is great interest in cyclic peptides because of their resistance to enzymatic degradation and higher selectivity compared to their linear counterparts. Lots of cyclic peptide libraries protocols have been recently developed to facilitate hits analysis. The aim of this review is to summarize the latest applications of solid phase screening of OBOC combinatorial peptide libraries, the improvements in the screening methods including mass spectrometry MS/MS techniques and the strategies to synthesize OBOC cyclic peptide libraries. © 2016 Bentham Science Publishers.

Registro:

Documento: Artículo
Título:Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries
Autor:Martínez-Ceron, M.C.; Giudicessi, S.L.; Saavedra, S.L.; Gurevich-Messina, J.M.; Erra-Balsells, R.; Albericio, F.; Cascone, O.; Camperi, S.A.
Filiación:NANOBIOTEC Institute, UBA-CONICET, Cathedra of Biotechnology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Junín 956, Buenos Aires, 1113, Argentina
CIHIDECAR-CONICET, Department of Organic Chemistry, School of Exact and Natural Sciences, UBA, Ciudad Universitaria, Pabellón II, Buenos Aires, 1428, Argentina
Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 10, Barcelona, 08028, Spain
Department of Organic Chemistry, University of Barcelona, Martí i Franquès 1-11, Barcelona, 08028, Spain
Barcelona Science Park, Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Baldiri Reixac 10, Barcelona, 08028, Spain
School of Chemistry and Physics, University of Kwazulu-Natal, Durban, 4001, South Africa
National Institute of Biologicals Production, ANLIS-Malbrán, Vélez Sársfield 563, CABA, 1281, Argentina
Palabras clave:Affinity; Cyclic; Libraries; Mass spectrometry; Peptide; Peptoid; Tandem MS/MS; amino acid; trifluoroacetic acid; cyclopeptide; ligand; peptide library; Article; combinatorial library; drug selectivity; electrospray; enzymatic degradation; human; mass spectrometry; matrix assisted laser desorption ionization time of flight mass spectrometry; one bead one compound peptide library; peptide library; screening; tandem mass spectrometry; chemistry; Humans; Ligands; Peptide Library; Peptides, Cyclic; Tandem Mass Spectrometry
Año:2016
Volumen:17
Número:5
Página de inicio:449
Página de fin:457
Título revista:Current Pharmaceutical Biotechnology
Título revista abreviado:Curr. Pharm. Biotechnol.
ISSN:13892010
CODEN:CPBUB
CAS:amino acid, 65072-01-7; trifluoroacetic acid, 14477-72-6, 2923-18-4, 76-05-1; Ligands; Peptide Library; Peptides, Cyclic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v17_n5_p449_MartinezCeron

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Citas:

---------- APA ----------
Martínez-Ceron, M.C., Giudicessi, S.L., Saavedra, S.L., Gurevich-Messina, J.M., Erra-Balsells, R., Albericio, F., Cascone, O.,..., Camperi, S.A. (2016) . Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries. Current Pharmaceutical Biotechnology, 17(5), 449-457.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v17_n5_p449_MartinezCeron [ ]
---------- CHICAGO ----------
Martínez-Ceron, M.C., Giudicessi, S.L., Saavedra, S.L., Gurevich-Messina, J.M., Erra-Balsells, R., Albericio, F., et al. "Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries" . Current Pharmaceutical Biotechnology 17, no. 5 (2016) : 449-457.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v17_n5_p449_MartinezCeron [ ]
---------- MLA ----------
Martínez-Ceron, M.C., Giudicessi, S.L., Saavedra, S.L., Gurevich-Messina, J.M., Erra-Balsells, R., Albericio, F., et al. "Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries" . Current Pharmaceutical Biotechnology, vol. 17, no. 5, 2016, pp. 449-457.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v17_n5_p449_MartinezCeron [ ]
---------- VANCOUVER ----------
Martínez-Ceron, M.C., Giudicessi, S.L., Saavedra, S.L., Gurevich-Messina, J.M., Erra-Balsells, R., Albericio, F., et al. Latest advances in OBOC peptide libraries. Improvements in screening strategies and enlarging the family from linear to cyclic libraries. Curr. Pharm. Biotechnol. 2016;17(5):449-457.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v17_n5_p449_MartinezCeron [ ]