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Abstract:

The metastatic cascade and colonization remains a major challenge in clinical therapeutics. The formation ofmetastasis has many rate limiting steps. The expression of metastases initiation genes in primary tumors is driven by theneed for cell motility, invasiveness, handling the shear stress in the vasculature and lymphatic circulation, and the survivaland persistent growth in the distant organ. However, the expression of the progression genes in the primary tumors has amore complex basis. These metastasis-prone genes support primary tumor growth through one particular effect, whereasthey enhance distant metastasis through another effect. The boundaries between metastasis initiation and metastasis progressiongenes are not rigid. In this review, we examine novel gene signatures identified in metastases, address key inflammatoryfactors mastering homing selection, gain further mechanistic insights into cell plasticity and evaluate the roleof microRNAs. Moreover, we also describe the recent progress in developing nanoparticle imaging substantiating a promisingtheranostic platform for future cancer diagnostics and treatment, and assess the relevance of the bioinformatic analysisof metastasis-related proteins with an eye toward the metastatic niche. All these tools will provide valuable biologicalinformation of the progression of the disease, helping find potential therapeutic targets and improving surgical procedures.In a near future the understanding of the molecular mechanisms in tumor dissemination will be pivotal for the translationof these methods to the clinic and will help to overcome the barriers in clinical therapy of metastases. © 2011 Bentham Science Publishers.

Registro:

Documento: Artículo
Título:Key questions in metastasis: New insights in molecular pathways and therapeutic implications
Autor:Gueron, G.; de Siervi, A.; Vazquez, E.
Filiación:Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Ciudad Universitaria, Pabellon II, 2do Piso (1428), Buenos Aires, Argentina
Palabras clave:Epithelial-mesenchymal-transition; Gene-signature; Inflammation; Metastasis; Microrna; Therapy; Vascular mimicry; antineoplastic agent; beta catenin; chemokine receptor CXCR4; cyclophosphamide; cytokine; epidermal growth factor; epithelial derived neutrophil activating factor 78; etoposide; galectin 3; gelatinase B; interleukin 6; interleukin 8; microRNA; monoclonal antibody; nanoparticle; platelet derived growth factor; prednisone; procarbazine; protein p53; protein tyrosine kinase inhibitor; rituximab; scatter factor; STAT1 protein; thalidomide; transforming growth factor beta; trastuzumab; uvomorulin; vasculotropin A; vasculotropin D; vasculotropin receptor 3; anaerobic glycolysis; angiogenesis; bone metastasis; breast cancer; cancer growth; cell homing; colorectal cancer; epithelial mesenchymal transition; gene expression; human; mantle cell lymphoma; metastasis; nonhuman; recurrent cancer; review; tumor microenvironment
Año:2011
Volumen:12
Número:11
Página de inicio:1867
Página de fin:1880
DOI: http://dx.doi.org/10.2174/138920111798376996
Título revista:Current Pharmaceutical Biotechnology
Título revista abreviado:Curr. Pharm. Biotechnol.
ISSN:13892010
CODEN:CPBUB
CAS:chemokine receptor CXCR4, 188900-71-2; cyclophosphamide, 50-18-0; epidermal growth factor, 59459-45-9, 62229-50-9; epithelial derived neutrophil activating factor 78, 136956-40-6; etoposide, 33419-42-0, 433304-61-1; galectin 3, 208128-56-7; gelatinase B, 146480-36-6; interleukin 8, 114308-91-7; prednisone, 53-03-2; procarbazine, 366-70-1, 671-16-9; rituximab, 174722-31-7; scatter factor, 67256-21-7, 72980-71-3; thalidomide, 50-35-1; trastuzumab, 180288-69-1; uvomorulin, 112956-45-3; vasculotropin A, 489395-96-2; vasculotropin D, 193363-12-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13892010_v12_n11_p1867_Gueron

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Citas:

---------- APA ----------
Gueron, G., de Siervi, A. & Vazquez, E. (2011) . Key questions in metastasis: New insights in molecular pathways and therapeutic implications. Current Pharmaceutical Biotechnology, 12(11), 1867-1880.
http://dx.doi.org/10.2174/138920111798376996
---------- CHICAGO ----------
Gueron, G., de Siervi, A., Vazquez, E. "Key questions in metastasis: New insights in molecular pathways and therapeutic implications" . Current Pharmaceutical Biotechnology 12, no. 11 (2011) : 1867-1880.
http://dx.doi.org/10.2174/138920111798376996
---------- MLA ----------
Gueron, G., de Siervi, A., Vazquez, E. "Key questions in metastasis: New insights in molecular pathways and therapeutic implications" . Current Pharmaceutical Biotechnology, vol. 12, no. 11, 2011, pp. 1867-1880.
http://dx.doi.org/10.2174/138920111798376996
---------- VANCOUVER ----------
Gueron, G., de Siervi, A., Vazquez, E. Key questions in metastasis: New insights in molecular pathways and therapeutic implications. Curr. Pharm. Biotechnol. 2011;12(11):1867-1880.
http://dx.doi.org/10.2174/138920111798376996