Artículo

Sanchez, S.M.; Abulafia, C.; Duarte-Abritta, B.; De Guevara, M.S.L.; Castro, M.N.; Drucaroff, L.; Sevlever, G.; Nemeroff, C.B.; Vigo, D.E.; Loewenstein, D.A.; Villarreal, M.F.; Guinjoan, S.M. "Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease" (2017) Journal of Alzheimer's Disease. 60(3):1183-1193
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Abstract:

Background: We have obtained previous evidence of limbic dysfunction in middle-Aged, asymptomatic offspring of lateonset Alzheimer's disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for LOAD. Objective: To assess the effects of specific proactive semantic interference deficits as they relate to functional magnetic resonance imaging (fMRI) neocortical and limbic functional connectivity in middle aged offspring of individuals with LOAD (O-LOAD) and age-equivalent controls. Methods:We examined 21O-LOADand 20 controls without family history of neurodegenerative disorders (CS) on traditional measures of cognitive functioning and the LASSI-L, a novel semantic interference test uniquely sensitive to the failure to recover from proactive interference (frPSI). Cognitive tests then were correlated to fMRI connectivity of seeds located in entorhinal cortex and anterodorsal thalamic nuclei among O-LOAD and CS participants. Results: Relative to CS, O-LOAD participants evidenced lower connectivity between entorhinal cortex and orbitofrontal, anterior cingulate, and anterior temporal cortex. In the offspring of LOAD patients, LASSI-L measures of frPSI were inversely associated with connectivity between anterodorsal thalamus and contralateral posterior cingulate. Intrusions on the task related to frPSI were inversely correlated with a widespread connectivity network involving hippocampal, insular, posterior cingulate, and dorsolateral prefrontal cortices, along with precunei and anterior thalamus in this group. Different patterns of connectivity associated with frPSI were observed among controls. Conclusion: The present results suggest that both semantic interference deficits and connectivity abnormalities might reflect limbic circuit dysfunction as a very early clinical signature of LOAD pathology, as previously demonstrated for other limbic phenotypes, such as sleep and circadian alterations.

Registro:

Documento: Artículo
Título:Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease
Autor:Sanchez, S.M.; Abulafia, C.; Duarte-Abritta, B.; De Guevara, M.S.L.; Castro, M.N.; Drucaroff, L.; Sevlever, G.; Nemeroff, C.B.; Vigo, D.E.; Loewenstein, D.A.; Villarreal, M.F.; Guinjoan, S.M.
Filiación:Service of Psychiatry, FLENI Foundation, Buenos Aires, Argentina
National Council for Scientific and Technological Research (CONICET), Argentina
Institute for Biomedical Research (BIOMED), Pontifical Catholic University of Argentina, National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina
Department of Neuropathology and Molecular Biology, FLENI Foundation, Buenos Aires, Argentina
Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL, United States
Department of Psychiatry and Mental Health, University of Buenos Aires School of Medicine, Argentina
Neurophysiology i, University of Buenos Aires School of Psychology, Argentina
Department of Physics (FCEyN), University of Buenos Aires, Argentina
Psychiatry and Neurophysiology, University of Buenos Aires Schools of Medicine and Psychology, Principal Investigator, Montañeses 2325, AQK Buenos AiresC1428, Argentina
Palabras clave:Entorhinal cortex; functional connectivity; late-onset Alzheimer's disease; limbic; proactive semantic interference; thalamus; adult; age; Alzheimer disease; anterior cingulate; anterior temporal cortex; Article; asymptomatic disease; Beck Depression Inventory; brain disease; brain function; clinical article; cognition; cognition assessment; cognitive function test; cognitive reserve; Cognitive Reserve Questionnaire; controlled study; convalescence; cross-sectional study; dorsolateral prefrontal cortex; entorhinal cortex; female; functional connectivity; functional magnetic resonance imaging; functional neuroimaging; high risk patient; human; image analysis; image processing; insula; limbic system; Loewenstein Acevedo Scales for Semantic Interference and Learning cognitive stress test; male; medial orbitofrontal cortex; middle aged; middle frontal gyrus; Mini Mental State Examination; neocortex; posterior cingulate; precuneus; priority journal; proactive semantic interference; Rey auditory verbal learning test; right hippocampus; temporal cortex; thalamus anterior nucleus; trail making test; adult child; Alzheimer disease; brain mapping; cognition; diagnostic imaging; genetic predisposition; genetics; limbic system; nerve tract; neuropsychological test; nuclear magnetic resonance imaging; onset age; pathophysiology; prodromal symptom; psychology; semantics; Adult Children; Age of Onset; Alzheimer Disease; Brain Mapping; Cognition; Cross-Sectional Studies; Female; Genetic Predisposition to Disease; Humans; Limbic System; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Neuropsychological Tests; Prodromal Symptoms; Semantics
Año:2017
Volumen:60
Número:3
Página de inicio:1183
Página de fin:1193
DOI: http://dx.doi.org/10.3233/JAD-170491
Título revista:Journal of Alzheimer's Disease
Título revista abreviado:J. Alzheimer's Dis.
ISSN:13872877
CODEN:JADIF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13872877_v60_n3_p1183_Sanchez

Referencias:

  • Dubois, B., Hampel, H., Feldman, H.H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Jack, C.R., Jr., Preclinical alzheimers disease: Definition, natural history, and diagnostic criteria (2016) Alzheimers Dement, 12, pp. 292-323
  • Alzheimer, A., Uber eine eigenartige erkrankung der hirnrinde (1907) Allg Zschr Psychiatr Psych Gerichtl Med, 64, pp. 146-148
  • Hardy, J.A., Higgins, G.A., Alzheimers disease: The amyloid cascade hypothesis (1992) Science, 256, p. 184
  • Cummings, J.L., Morstorf, T., Zhong, K., Alzheimers disease drug-development pipeline: Few candidates, frequent failures (2014) Alzheimers Res Ther, 6, p. 37
  • Braak, H., Braak, E., Neuropathological stageing of Alzheimer-related changes (1991) Acta Neuropathol, 82, pp. 239-259
  • Braak, H., Del Tredici, K., The pathological process underlying Alzheimers disease in individuals under thirty (2011) Acta Neuropathol, 121, pp. 171-181
  • Walsh, C., Drinkenburg, W.H., Ahnaou, A., Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimers disease (2017) Neurosci Biobehav Rev, 73, pp. 340-358
  • Wang, L., Roe, C.M., Snyder, A.Z., Brier, M.R., Thomas, J.B., Xiong, C., Benzinger, T.L., Ances, B.M., Alzheimer disease family history impacts resting state functional connectivity (2012) Ann Neurol, 72, pp. 571-577
  • Gour, N., Felician, O., Didic, M., Koric, L., Gueriot, C., Chanoine, V., Confort-Gouny, S., Ranjeva, J.P., Functional connectivity changes differ in early and late-onset alzheimers disease (2014) Hum Brain Mapp, 35, pp. 2978-2994
  • Loewenstein, D.A., Curiel, R.E., Duara, R., Buschke, H., Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimers disease (2017) Assessment
  • Loewenstein, D.A., Curiel, R.E., Greig, M.T., Bauer, R.M., Rosado, M., Bowers, D., Wicklund, M., Duara, R., A novel cognitive stress test for the detection of preclinical Alzheimer disease: Discriminative properties and relation to amyloid load (2016) Am J Geriatr Psychiatry, 24, pp. 804-813
  • Crocco, E., Curiel, R.E., Acevedo, A., Czaja, S.J., Loewenstein, D.A., An evaluation of deficits in semantic cueing and proactive and retroactive interference as early features of Alzheimers disease (2014) Am J Geriatr Psychiatry, 22, pp. 889-897
  • Loewenstein, D.A., Curiel, R.E., Wright, C., Sun, X., Alperin, N., Crocco, E., Czaja, S.J., Duara, R., Recovery from proactive semantic interference in mild cognitive impairment and normal aging: Relationship to atrophy in brain regions vulnerable to Alzheimers disease (2017) J Alzheimers Dis, 56, pp. 1119-1126
  • Loewenstein, D.A., Curiel, R.E., DeKosky, S., Rosselli, M., Bauer, R., Grieg-Custo, M., Penate, A., Duara, R., Recovery from proactive semantic interference and MRI volume: A replication and extension study (2017) J Alzheimers Dis, 59, pp. 131-139
  • Child, N.D., Benarroch, E.E., Anterior nucleus of the thalamus: Functional organization and clinical implications (2013) Neurology, 81, pp. 1869-1876
  • (2013) Diagnostic and Statistical Manual of Mental Disorders, , American Psychiatric Association 5th ed American Psychiatric Association, Washington, DC
  • Folsteinmf Folstein, S.E., McHugh, P.R., Mini-mental state. A practical method for grading the cognitive state of patients for the clinician (1975) J Psychiatr Res, 12, pp. 189-198
  • Reitan, R.M., Wolfson, D., (1985) The Halstead-Reitan Neuropsycholgical Test Battery: Therapy and Clinical Interpretation, , Neuropsychological Press, Tucson, AZ
  • Artiola, L., Hermosillo, D., Heaton, R., Pardee, R.E., Manual de normas y procedimientos para la (1999) Batería Neuropsicológica en Español Manual of Norms and Procedures for the Spanish Neuropsychological Battery, , M Press, Tucson, AZ
  • Goodglass, H., Kaplan, E., (1983) The Assessment of Aphasia and Related Disorders, , 2nd ed. Lea and Febiger, Philadelphia, PA
  • Rey, A., (1964) LExamen Clinique en Psychologie, , Presses Universitaires de France, Paris
  • Schmidt, M., (1996) Rey Auditory and Verbal Learning Test: A Handbook, , Western Psychological Services, Los Angeles
  • Matias-Guiu, J.A., Curiel, R.E., Rognoni, T., Valles-Salgado, M., Fernández-Matarrubia, M., Hariramani, R., Fernández-Castro, A., Loewensteinda Matias-Guiu, J., Validation of the Spanish version of the lassi-l for diagnosing mild cognitive impairment and alzheimers disease (2017) J Alzheimers Dis, 56, pp. 733-742
  • Rami, L., Valls-Pedret, C., Bartrés-Faz, D., Caprile, C., Solé-Padullés, C., Castellvi, M., Olives, J., Molinuevo, J.L., Cognitive reserve questionnaire. Scores obtained in a healthy elderly population and in one with Alzheimers disease (2011) Rev Neurol, 52, pp. 195-201
  • Talairach, J., Tournoux, P., (1988) Co-planar Stereotaxic Atlas of the Human Brain. 3-Dimensional Proportional System: An Approach to Cerebral Imaging, , Thieme Medical Publishers
  • Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoner, B., Joliot, M., Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) Neuroimage, 15, pp. 273-289
  • Desikan, R.S., Segonne, F., Fischl, B., Quinn, B.T., Dickerson, B.C., Blacker, D., Buckner, R.L., Killiany, R.J., An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest (2006) Neuroimage, 31, pp. 968-980
  • Jakab, A., Blanc, R., Bérenyi, E.L., Sékely, G., Generation of individualized thalamus target maps by using statistical shape models and thalamocortical tractography (2012) AJNR Am J Neuroradiol, 33, pp. 2110-2116
  • Xia, M., Wang, J., He, Y., Brainnet viewer: A network visualization tool for human brain connectomics (2013) PLoS One, 8, p. e68910
  • Van Hoesen, G., Pandya, D.N., Butters, N., Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents (1975) Brain Res, 95, pp. 25-38
  • Van Hoesen, G.W., Pandya, D.N., Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections (1975) Brain Res, 95, pp. 39-59
  • Insausti, R., Amaral, D.G., Cowan, W.M., The entorhinal cortex of the monkey: II. Cortical afferents (1987) J Comp Neurol, 264, pp. 356-395
  • Abulafia, C., Duarte-Abritta, B., Villarreal, M.F., Ladrón-De-Guevara, M.S., García, C., Sequeyra, G., Sevlever, G., Guinjoan, S.M., Relationship between cognitive and sleep-wake variables in asymptomatic offspring of patients with late-onset Alzheimers disease (2017) Front Aging Neurosci, 9, p. 93
  • Bloom, G.S., Amyloid-And tau: The trigger and bullet in Alzheimer disease pathogenesis (2014) JAMA Neurol, 71, pp. 505-508
  • Bassett, S.S., YousemDM, C.C., Kusevic, I., Yassa, M.A., Caffo, B.S., Zeger, S.L., Familial risk for Alzheimers disease alters fMRI activation patterns (2006) Brain, 129, pp. 1229-1239
  • Frisoni, G.B., Pievani, M., Testa, C., Sabattoli, F., Bresciani, L., Bonetti, M., Beltrameloo, A., Thompson, P.M., The topography of grey matter involvement in early and late onset Alzheimers disease (2007) Brain, 130, pp. 720-730
  • Smits, L.L., Pijnenburg, Y.A., Koedam, E.L., Esther, L.G., Van Der Vlies, A.E., Reuling, I.E., Koene, T., Van Der Flier, W.M., Early onset Alzheimers disease is associated with a distinct neuropsychological profile (2012) J Alzheimers Dis, 30, pp. 101-108

Citas:

---------- APA ----------
Sanchez, S.M., Abulafia, C., Duarte-Abritta, B., De Guevara, M.S.L., Castro, M.N., Drucaroff, L., Sevlever, G.,..., Guinjoan, S.M. (2017) . Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease. Journal of Alzheimer's Disease, 60(3), 1183-1193.
http://dx.doi.org/10.3233/JAD-170491
---------- CHICAGO ----------
Sanchez, S.M., Abulafia, C., Duarte-Abritta, B., De Guevara, M.S.L., Castro, M.N., Drucaroff, L., et al. "Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease" . Journal of Alzheimer's Disease 60, no. 3 (2017) : 1183-1193.
http://dx.doi.org/10.3233/JAD-170491
---------- MLA ----------
Sanchez, S.M., Abulafia, C., Duarte-Abritta, B., De Guevara, M.S.L., Castro, M.N., Drucaroff, L., et al. "Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease" . Journal of Alzheimer's Disease, vol. 60, no. 3, 2017, pp. 1183-1193.
http://dx.doi.org/10.3233/JAD-170491
---------- VANCOUVER ----------
Sanchez, S.M., Abulafia, C., Duarte-Abritta, B., De Guevara, M.S.L., Castro, M.N., Drucaroff, L., et al. Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease. J. Alzheimer's Dis. 2017;60(3):1183-1193.
http://dx.doi.org/10.3233/JAD-170491