Abstract:
The synthesis of galacturonate disaccharides has been performed from suitable protected monosaccharides. The use of orthogonal protecting groups allowed us to obtain both methyl galacturonates and galacturonic acid precursors as glycosylation donors or acceptors from a unique monosaccharide derivative. The protecting groups used allowed selective introduction of a fatty acid chain to the non-reducing end of a disaccharide. Furthermore, we explored the preparation of galacturonate conjugated to a carrier protein, and determined the number of sugar residues coupled to the protein by MALDI-MS. © 2011 Bentham Science Publishers.
Registro:
Documento: |
Artículo
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Título: | Synthesis of galacturonate containing disaccharides and protein conjugates |
Autor: | Pourcelot, M.; Barbier, M.; Landoni, M.; Couto, A.S.; Grand, E.; Kovensky, J. |
Filiación: | Laboratoire des Glucides CNRS UMR 6219, Institut de Chimie de Picardie, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France CIHIDECAR (CONICET), Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab II, 1428 Buenos Aires, Argentina
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Palabras clave: | Conjugates; Galacturonate; Glycosylation; MALDI-MS; Synthesis |
Año: | 2011
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Volumen: | 15
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Número: | 19
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Página de inicio: | 3523
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Página de fin: | 3534
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DOI: |
http://dx.doi.org/10.2174/138527211797374706 |
Título revista: | Current Organic Chemistry
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Título revista abreviado: | Curr. Org. Chem.
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ISSN: | 13852728
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CODEN: | CORCF
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13852728_v15_n19_p3523_Pourcelot |
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Citas:
---------- APA ----------
Pourcelot, M., Barbier, M., Landoni, M., Couto, A.S., Grand, E. & Kovensky, J.
(2011)
. Synthesis of galacturonate containing disaccharides and protein conjugates. Current Organic Chemistry, 15(19), 3523-3534.
http://dx.doi.org/10.2174/138527211797374706---------- CHICAGO ----------
Pourcelot, M., Barbier, M., Landoni, M., Couto, A.S., Grand, E., Kovensky, J.
"Synthesis of galacturonate containing disaccharides and protein conjugates"
. Current Organic Chemistry 15, no. 19
(2011) : 3523-3534.
http://dx.doi.org/10.2174/138527211797374706---------- MLA ----------
Pourcelot, M., Barbier, M., Landoni, M., Couto, A.S., Grand, E., Kovensky, J.
"Synthesis of galacturonate containing disaccharides and protein conjugates"
. Current Organic Chemistry, vol. 15, no. 19, 2011, pp. 3523-3534.
http://dx.doi.org/10.2174/138527211797374706---------- VANCOUVER ----------
Pourcelot, M., Barbier, M., Landoni, M., Couto, A.S., Grand, E., Kovensky, J. Synthesis of galacturonate containing disaccharides and protein conjugates. Curr. Org. Chem. 2011;15(19):3523-3534.
http://dx.doi.org/10.2174/138527211797374706