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Abstract:

Chagas' disease or American trypanosomiasis is considered by the Word Health Organization to be one of the important tropical parasitic diseases worldwide together with malaria and schistosomiasis. The etiologic agent of this illness is the kinetoplastid protozoon Trypanosoma cruzi. The present chemotherapy for the treatment of Chagas' disease remains unsolved. The drugs currently in use are old, ineffective and toxic. Bearing in mind the metabolic differences between the parasite and the mammalian host, some attractive interesting molecular targets for drug design are presented.

Registro:

Documento: Artículo
Título:Specific molecular targets to control tropical diseases
Autor:Rodriguez, J.B.
Filiación:Dept. de Química Organica, Facultad Ciencias Exactas Naturales, Universidad de Buenos Aires, Pabellón 2, RA-1428 Buenos Aires, Argentina
Palabras clave:4 phenoxyphenoxyethyl allyl ether; 4 phenoxyphenoxyethyl tetrahydro 2h pyran 2 yl ether; 4 phenoxyphenoxyethyl thiocyanate; antiinfective agent; aryloxyethyl thiocyanate; benznidazole; benzoic acid derivative; crystal violet; dihydrofolate reductase inhibitor; enzyme inhibitor; ether derivative; fenoxycarb; glyceraldehyde 3 phosphate dehydrogenase inhibitor; m chloroperbenzoic acid; methotrexate; n acetyl 2,3 didehydro 2 deoxyneuraminic acid; n acetylneuraminic acid derivative; nifurtimox; sialidase; thiocyanic acid derivative; unclassified drug; animal experiment; animal model; anorexia; article; Chagas disease; controlled study; drug design; drug structure; drug targeting; host; human; kinetoplast; malaria; mammal; molecular biology; mouse; nonhuman; peripheral neuropathy; priority journal; protozoon; schistosomiasis; skin allergy; tropical disease; Trypanosoma cruzi; vomiting; world health organization; Animals; Antiprotozoal Agents; Chagas Disease; Drug Design; Humans; Trypanosoma cruzi
Año:2001
Volumen:7
Número:12
Página de inicio:1105
Página de fin:1116
DOI: http://dx.doi.org/10.2174/1381612013397555
Título revista:Current Pharmaceutical Design
Título revista abreviado:Curr. Pharm. Des.
ISSN:13816128
CODEN:CPDEF
CAS:Antiprotozoal Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13816128_v7_n12_p1105_Rodriguez

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Citas:

---------- APA ----------
(2001) . Specific molecular targets to control tropical diseases. Current Pharmaceutical Design, 7(12), 1105-1116.
http://dx.doi.org/10.2174/1381612013397555
---------- CHICAGO ----------
Rodriguez, J.B. "Specific molecular targets to control tropical diseases" . Current Pharmaceutical Design 7, no. 12 (2001) : 1105-1116.
http://dx.doi.org/10.2174/1381612013397555
---------- MLA ----------
Rodriguez, J.B. "Specific molecular targets to control tropical diseases" . Current Pharmaceutical Design, vol. 7, no. 12, 2001, pp. 1105-1116.
http://dx.doi.org/10.2174/1381612013397555
---------- VANCOUVER ----------
Rodriguez, J.B. Specific molecular targets to control tropical diseases. Curr. Pharm. Des. 2001;7(12):1105-1116.
http://dx.doi.org/10.2174/1381612013397555