Abstract:
In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their straightforward synthesis implied two consecutive Ugi reactions and can be efficiently extended to the construction of highly diverse libraries. © 2011 Springer Science+Business Media B.V.
Registro:
Documento: |
Artículo
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Título: | Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
Autor: | Galetti, M.D.; Cirigliano, A.M.; Cabrera, G.M.; Ramírez, J.A. |
Filiación: | Departamento de Química Orgánica, UMYMFOR (CONICET - Facultad de Ciencias Exactas Y Naturales), Universidad de Buenos Aires, C1428EGA, Buenos Aires, Argentina
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Palabras clave: | Acylated peptoids; Antifungal; Multicomponent reaction; Plant pathogen; glycine; peptoid; acylation; antifungal activity; article; chemical reaction; drug structure; drug synthesis; electrospray mass spectrometry; minimum inhibitory concentration; nonhuman; plant disease; priority journal; ugi reaction; Acylation; Amines; Antifungal Agents; Fusarium; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Peptoids; Plants; Spectrometry, Mass, Electrospray Ionization |
Año: | 2012
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Volumen: | 16
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Número: | 1
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Página de inicio: | 113
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Página de fin: | 119
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DOI: |
http://dx.doi.org/10.1007/s11030-011-9334-1 |
Título revista: | Molecular Diversity
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Título revista abreviado: | Mol. Diversity
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ISSN: | 13811991
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CODEN: | MODIF
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CAS: | glycine, 56-40-6, 6000-43-7, 6000-44-8; Amines; Antifungal Agents; Peptoids
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811991_v16_n1_p113_Galetti |
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Citas:
---------- APA ----------
Galetti, M.D., Cirigliano, A.M., Cabrera, G.M. & Ramírez, J.A.
(2012)
. Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens. Molecular Diversity, 16(1), 113-119.
http://dx.doi.org/10.1007/s11030-011-9334-1---------- CHICAGO ----------
Galetti, M.D., Cirigliano, A.M., Cabrera, G.M., Ramírez, J.A.
"Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens"
. Molecular Diversity 16, no. 1
(2012) : 113-119.
http://dx.doi.org/10.1007/s11030-011-9334-1---------- MLA ----------
Galetti, M.D., Cirigliano, A.M., Cabrera, G.M., Ramírez, J.A.
"Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens"
. Molecular Diversity, vol. 16, no. 1, 2012, pp. 113-119.
http://dx.doi.org/10.1007/s11030-011-9334-1---------- VANCOUVER ----------
Galetti, M.D., Cirigliano, A.M., Cabrera, G.M., Ramírez, J.A. Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens. Mol. Diversity. 2012;16(1):113-119.
http://dx.doi.org/10.1007/s11030-011-9334-1