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Trelles, J.A.; Bentancor, L.; Grasselli, M.; Lewkowicz, E.S.; Iribarren, A.M. "Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support" (2008) Journal of Molecular Catalysis B: Enzymatic. 52-53(1-4):189-193
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Abstract:

Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They are extensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient, ecological and low cost biocatalysts that have been successfully applied to the preparation of these compounds. A new support for cell immobilization that involves the use of a macroporous polyethylene polymer grafted with chains of polyglycidyl methacrylate-ethylendiamine is described in this paper. High stability and productivity and easy handling are some of the advantages of the here developed biocatalyst. © 2007 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support
Autor:Trelles, J.A.; Bentancor, L.; Grasselli, M.; Lewkowicz, E.S.; Iribarren, A.M.
Filiación:Universidad Nacional de Quilmes, Roque Saenz Peña 352, 1876 Bernal Buenos Aires, Argentina
INGEBI, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Adenosine; Escherichia coli BL21; Nucleoside phosphorylases; Polyethylene; Whole cell immobilization; Adenosine; Antitumors; Nucleoside phosphorylases; Nucleosides; Cell immobilization; Enzymes; Escherichia coli; Graft copolymers; Synthesis (chemical); Polyethylenes; antineoplastic agent; antisense oligonucleotide; antivirus agent; nucleoside; oligonucleotide; polyethylene; polyglycidyl methacrylate ethylenediamine; polymer; unclassified drug; article; biocatalyst; catalyst support; cost minimization analysis; drug synthesis; immobilized cell; molecular stability; nucleic acid synthesis; pharmaceutical engineering; porosity; process development; productivity; Escherichia coli
Año:2008
Volumen:52-53
Número:1-4
Página de inicio:189
Página de fin:193
DOI: http://dx.doi.org/10.1016/j.molcatb.2007.12.014
Título revista:Journal of Molecular Catalysis B: Enzymatic
Título revista abreviado:J. Mol. Catal. B Enzym.
ISSN:13811177
CODEN:JMCEF
CAS:polyethylene, 9002-88-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811177_v52-53_n1-4_p189_Trelles

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Citas:

---------- APA ----------
Trelles, J.A., Bentancor, L., Grasselli, M., Lewkowicz, E.S. & Iribarren, A.M. (2008) . Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support. Journal of Molecular Catalysis B: Enzymatic, 52-53(1-4), 189-193.
http://dx.doi.org/10.1016/j.molcatb.2007.12.014
---------- CHICAGO ----------
Trelles, J.A., Bentancor, L., Grasselli, M., Lewkowicz, E.S., Iribarren, A.M. "Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support" . Journal of Molecular Catalysis B: Enzymatic 52-53, no. 1-4 (2008) : 189-193.
http://dx.doi.org/10.1016/j.molcatb.2007.12.014
---------- MLA ----------
Trelles, J.A., Bentancor, L., Grasselli, M., Lewkowicz, E.S., Iribarren, A.M. "Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support" . Journal of Molecular Catalysis B: Enzymatic, vol. 52-53, no. 1-4, 2008, pp. 189-193.
http://dx.doi.org/10.1016/j.molcatb.2007.12.014
---------- VANCOUVER ----------
Trelles, J.A., Bentancor, L., Grasselli, M., Lewkowicz, E.S., Iribarren, A.M. Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support. J. Mol. Catal. B Enzym. 2008;52-53(1-4):189-193.
http://dx.doi.org/10.1016/j.molcatb.2007.12.014