Abstract:
Benzimidazole nucleosides are compounds with interesting pharmacological properties. Although chemical synthesis of these analogues has been carried out, only few derivatives have been obtained so far using biotransformations. We report herein the biocatalysed preparation of benzimidazole ribo- and 2′-deoxyribonucleosides by different microbial whole cells that afforded yields between 75 and 85%. © 2004 Elsevier B.V. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Benzimidazole as deazapurine analogue for microbial transglycosylation |
Autor: | Bentancor, L.; Trelles, J.A.; Nóbile, M.; Lewkowicz, E.S.; Iribarren, A.M. |
Filiación: | Universidad Nacional de Quilmes, R.S. Peña 180, (1876) Bernal, Buenos Aires, Argentina INGEBI, CONICET, Vuelta de Obligado 2490, (1428) Buenos Aires, Argentina
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Palabras clave: | Benzimidazole; Microbial transglycosylation; Nucleoside analogues; Whole cells; Cells; Derivatives; Synthesis (chemical); Benzimidazole; Biotransformations; Pharmacological properties; Catalysis; benzimidazole; benzimidazole 2' deoxyriboside; benzimidazole riboside; purine derivative; unclassified drug; bacterial cell; catalysis; conference paper; controlled study; drug synthesis; drug transformation; glycosylation; microorganism; nonhuman |
Año: | 2004
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Volumen: | 29
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Número: | 1-6
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Página de inicio: | 3
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Página de fin: | 7
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DOI: |
http://dx.doi.org/10.1016/j.molcatb.2003.10.007 |
Título revista: | Journal of Molecular Catalysis B: Enzymatic
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Título revista abreviado: | J. Mol. Catal. B Enzym.
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ISSN: | 13811177
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CODEN: | JMCEF
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CAS: | benzimidazole, 51-17-2
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811177_v29_n1-6_p3_Bentancor |
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Citas:
---------- APA ----------
Bentancor, L., Trelles, J.A., Nóbile, M., Lewkowicz, E.S. & Iribarren, A.M.
(2004)
. Benzimidazole as deazapurine analogue for microbial transglycosylation. Journal of Molecular Catalysis B: Enzymatic, 29(1-6), 3-7.
http://dx.doi.org/10.1016/j.molcatb.2003.10.007---------- CHICAGO ----------
Bentancor, L., Trelles, J.A., Nóbile, M., Lewkowicz, E.S., Iribarren, A.M.
"Benzimidazole as deazapurine analogue for microbial transglycosylation"
. Journal of Molecular Catalysis B: Enzymatic 29, no. 1-6
(2004) : 3-7.
http://dx.doi.org/10.1016/j.molcatb.2003.10.007---------- MLA ----------
Bentancor, L., Trelles, J.A., Nóbile, M., Lewkowicz, E.S., Iribarren, A.M.
"Benzimidazole as deazapurine analogue for microbial transglycosylation"
. Journal of Molecular Catalysis B: Enzymatic, vol. 29, no. 1-6, 2004, pp. 3-7.
http://dx.doi.org/10.1016/j.molcatb.2003.10.007---------- VANCOUVER ----------
Bentancor, L., Trelles, J.A., Nóbile, M., Lewkowicz, E.S., Iribarren, A.M. Benzimidazole as deazapurine analogue for microbial transglycosylation. J. Mol. Catal. B Enzym. 2004;29(1-6):3-7.
http://dx.doi.org/10.1016/j.molcatb.2003.10.007