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Abstract:

INSECT is a user-friendly web server to predict the occurrence of Cis-Regulatory Modules (CRMs), which control gene expression. Here, we present a new release of INSECT which includes several new features, such as whole genome analysis, nucleosome occupancy predictions, and which provides additional links to third-party functional tools that complement user capabilities, CRM analysis and hypothesis construction. Improvements in the core implementation have led to a faster and more efficient tool. In addition, this new release introduces a new interface designed for a more integrative and dynamic user experience. © 2015 The Author. All rights reserved.

Registro:

Documento: Artículo
Título:INSECT 2.0: A web-server for genome-wide cis-regulatory modules prediction
Autor:Parra, R.G.; Rohr, C.O.; Koile, D.; Perez-Castro, C.; Yankilevich, P.
Filiación:Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigacion en Biomedicina de Buenos Aires (IBioBA), CONICET, Partner Institute of the Max Planck Society, Godoy Cruz 2390, Buenos Aires, C1425FQA, Argentina
Palabras clave:transcription factor; algorithm; binding site; computer simulation; genome; Internet; regulatory sequence; Algorithms; Binding Sites; Computer Simulation; Genome; Internet; Regulatory Elements, Transcriptional; Transcription Factors
Año:2016
Volumen:32
Número:8
Página de inicio:1229
Página de fin:1231
DOI: http://dx.doi.org/10.1093/bioinformatics/btv726
Título revista:Bioinformatics
Título revista abreviado:Bioinformatics
ISSN:13674803
CODEN:BOINF
CAS:Transcription Factors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13674803_v32_n8_p1229_Parra

Referencias:

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  • Pachkov, M., SwissRegulon, a database of genome-wide annotations of regulatory sites: Recent updates (2013) Nucleic Acids Res., 41, pp. D214-D220
  • Rohr, C.O., INSECT: IN-silico SEarch for Co-occurring Transcription factors (2013) Bioinformatics, 29, pp. 2852-2858
  • Soufi, A., Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming (2015) Cell, 161, pp. 555-568
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Citas:

---------- APA ----------
Parra, R.G., Rohr, C.O., Koile, D., Perez-Castro, C. & Yankilevich, P. (2016) . INSECT 2.0: A web-server for genome-wide cis-regulatory modules prediction. Bioinformatics, 32(8), 1229-1231.
http://dx.doi.org/10.1093/bioinformatics/btv726
---------- CHICAGO ----------
Parra, R.G., Rohr, C.O., Koile, D., Perez-Castro, C., Yankilevich, P. "INSECT 2.0: A web-server for genome-wide cis-regulatory modules prediction" . Bioinformatics 32, no. 8 (2016) : 1229-1231.
http://dx.doi.org/10.1093/bioinformatics/btv726
---------- MLA ----------
Parra, R.G., Rohr, C.O., Koile, D., Perez-Castro, C., Yankilevich, P. "INSECT 2.0: A web-server for genome-wide cis-regulatory modules prediction" . Bioinformatics, vol. 32, no. 8, 2016, pp. 1229-1231.
http://dx.doi.org/10.1093/bioinformatics/btv726
---------- VANCOUVER ----------
Parra, R.G., Rohr, C.O., Koile, D., Perez-Castro, C., Yankilevich, P. INSECT 2.0: A web-server for genome-wide cis-regulatory modules prediction. Bioinformatics. 2016;32(8):1229-1231.
http://dx.doi.org/10.1093/bioinformatics/btv726