Abstract:
The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we present a minimal continuum theory of vertebrate segmentation that captures the key principles governing the dynamic patterns of gene expression including the effects of shortening of the oscillating tissue. We show that our theory can quantitatively account for the key features of segmentation observed in zebrafish, in particular the shape of the wave patterns, the period of segmentation and the segment length as a function of time. © 2015 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft.
Registro:
Documento: |
Artículo
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Título: | Continuum theory of gene expression waves during vertebrate segmentation |
Autor: | Jörg, D.J.; Morelli, L.G.; Soroldoni, D.; Oates, A.C.; Jülicher, F. |
Filiación: | Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, Dresden, D-01187, Germany Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina IFIBA, CONICET, Ciudad Universitaria, Pabellón 1, Buenos Aires, 1428, Argentina Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom Max Planck Institute for Cell Biology and Genetics, Pfotenhauerstr. 108, Dresden, D-01307, Germany
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Palabras clave: | coupled oscillators, morphogenesis, pattern formation; Continuum mechanics; Genes; Tissue; Continuum theory; Dynamic patterns; Embryonic development; Function of time; Pattern formation; Segment lengths; Sequential process; Traveling wave; Gene expression |
Año: | 2015
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Volumen: | 17
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Número: | 9
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DOI: |
http://dx.doi.org/10.1088/1367-2630/17/9/093042 |
Título revista: | New Journal of Physics
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Título revista abreviado: | New J. Phys.
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ISSN: | 13672630
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13672630_v17_n9_p_Jorg |
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Citas:
---------- APA ----------
Jörg, D.J., Morelli, L.G., Soroldoni, D., Oates, A.C. & Jülicher, F.
(2015)
. Continuum theory of gene expression waves during vertebrate segmentation. New Journal of Physics, 17(9).
http://dx.doi.org/10.1088/1367-2630/17/9/093042---------- CHICAGO ----------
Jörg, D.J., Morelli, L.G., Soroldoni, D., Oates, A.C., Jülicher, F.
"Continuum theory of gene expression waves during vertebrate segmentation"
. New Journal of Physics 17, no. 9
(2015).
http://dx.doi.org/10.1088/1367-2630/17/9/093042---------- MLA ----------
Jörg, D.J., Morelli, L.G., Soroldoni, D., Oates, A.C., Jülicher, F.
"Continuum theory of gene expression waves during vertebrate segmentation"
. New Journal of Physics, vol. 17, no. 9, 2015.
http://dx.doi.org/10.1088/1367-2630/17/9/093042---------- VANCOUVER ----------
Jörg, D.J., Morelli, L.G., Soroldoni, D., Oates, A.C., Jülicher, F. Continuum theory of gene expression waves during vertebrate segmentation. New J. Phys. 2015;17(9).
http://dx.doi.org/10.1088/1367-2630/17/9/093042