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Cotignola, J.; Leonardi, D.B.; Shahabi, A.; Acuña, A.D.; Stern, M.C.; Navone, N.; Scorticati, C.; De Siervi, A.; Mazza, O.; Vazquez, E. "Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy" (2013) Prostate Cancer and Prostatic Diseases. 16(1):28-34
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Abstract:

Background:Organ confined prostate cancer (PCa) can be cured by radical retropubic prostatectomy (RRP); however, some tumors will still recur. Current tools fail to identify patients at risk of recurrence. Glutathione-S- transferases (GSTs) are involved in the metabolism of carcinogens, hormones and drugs. Thus, genetic polymorphisms that modify the GST activities may modify the risk of PCa recurrence.Methods:We retrospectively recruited Argentine PCa patients treated with RRP to study the association between GST polymorphisms and PCa biochemical relapse after RRP. We genotyped germline DNA in 105 patients for: GSTP1 c.313A>G (p.105 Ile>Val, rs1695) by PCR-RFLP; and GSTT1 null and GSTM1 null polymorphisms by multiplex PCR. Kaplan-Meier curves and Cox proportional hazard models were used to evaluate these associations.Results: Patients with GSTP1 c.313GG genotype showed shorter biochemical relapse-free survival (BRFS) (P=0.003) and higher risk for recurrence in unadjusted (Hazard ratio (HR)=3.16, 95% confidence interval (95% CI)=1.41-7.06, P=0.005) and multivariate models (HR=3.01, 95% CI=1.13-8.02, P=0.028). We did not find significant associations for GSTT1 and GSTM1 genotypes. In addition, we found shorter BRFS (P=0.010) and increased risk for recurrence for patients having two or more risk alleles when we combined the genotypes of the three GSTs in multivariate models (HR=3.06, 95% CI=1.20-7.80, P=0.019).Conclusions:Our results give support to the implementation of GSTs genotyping for personalized therapies as a novel alternative for PCa management for patients who undergo RRP. To the best of our knowledge, this is the first study that examined GST polymorphisms in PCa progression in Argentine men. Replication of our findings in larger cohort is warranted. © 2013 Macmillan Publishers Limited. All rights reserved.

Registro:

Documento: Artículo
Título:Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy
Autor:Cotignola, J.; Leonardi, D.B.; Shahabi, A.; Acuña, A.D.; Stern, M.C.; Navone, N.; Scorticati, C.; De Siervi, A.; Mazza, O.; Vazquez, E.
Filiación:Department of Biological Chemistry, School of Sciences, University of Buenos Aires - IQUIBICEN, Buenos Aires, Argentina
Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, Los Angeles, CA, United States
Department of Genitourinary Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, United States
Urology Service, Hospital de Clínicas José de San Martín, University of Buenos Aires, Buenos Aires, Argentina
Palabras clave:biochemical relapse; glutathione-S-transferase; GST; polymorphism; glutathione transferase; glutathione transferase M1; glutathione transferase T1; prostate antigen; adult; age distribution; aged; Argentina; article; cancer growth; cancer recurrence; cancer staging; controlled study; DNA polymorphism; enzyme activity; family history; gene frequency; genetic variability; genotype; GSTM1 gene; GSTT1 gene; homozygosity; human; major clinical study; male; nucleotide sequence; oncogene; phenotype; priority journal; prostate cancer; prostatectomy; recurrence free survival; recurrence risk; retrospective study; risk assessment; risk factor; single nucleotide polymorphism; smoking; Aged; Case-Control Studies; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prostatectomy; Prostatic Neoplasms; Risk Factors
Año:2013
Volumen:16
Número:1
Página de inicio:28
Página de fin:34
DOI: http://dx.doi.org/10.1038/pcan.2012.45
Título revista:Prostate Cancer and Prostatic Diseases
Título revista abreviado:Prostate Cancer Prostatic Dis.
ISSN:13657852
CODEN:PCPDF
CAS:glutathione transferase, 50812-37-8; Glutathione Transferase, 2.5.1.18
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13657852_v16_n1_p28_Cotignola

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Citas:

---------- APA ----------
Cotignola, J., Leonardi, D.B., Shahabi, A., Acuña, A.D., Stern, M.C., Navone, N., Scorticati, C.,..., Vazquez, E. (2013) . Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy. Prostate Cancer and Prostatic Diseases, 16(1), 28-34.
http://dx.doi.org/10.1038/pcan.2012.45
---------- CHICAGO ----------
Cotignola, J., Leonardi, D.B., Shahabi, A., Acuña, A.D., Stern, M.C., Navone, N., et al. "Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy" . Prostate Cancer and Prostatic Diseases 16, no. 1 (2013) : 28-34.
http://dx.doi.org/10.1038/pcan.2012.45
---------- MLA ----------
Cotignola, J., Leonardi, D.B., Shahabi, A., Acuña, A.D., Stern, M.C., Navone, N., et al. "Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy" . Prostate Cancer and Prostatic Diseases, vol. 16, no. 1, 2013, pp. 28-34.
http://dx.doi.org/10.1038/pcan.2012.45
---------- VANCOUVER ----------
Cotignola, J., Leonardi, D.B., Shahabi, A., Acuña, A.D., Stern, M.C., Navone, N., et al. Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy. Prostate Cancer Prostatic Dis. 2013;16(1):28-34.
http://dx.doi.org/10.1038/pcan.2012.45