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Abstract:

Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society.

Registro:

Documento: Artículo
Título:Observable effects of Ca2+ buffers on local Ca2+ signals
Autor:Solovey, G.; Dawson, S.P.
Filiación:Laboratory of Mathematical Physics, Rockefeller University, 1230 York Avenue, New York, NY 10065, United States
Departamento de Física, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Buffers; Puffs; Sugars; Transport properties; Buffers; High resolution; Local signal; Optical experiments; Physiological process; Puffs; Calcium; buffer; calcium; inositol 1,4,5 trisphosphate; algorithm; article; biological model; calcium signaling; cell membrane; channel gating; chemistry; computer simulation; cytosol; dose response; endoplasmic reticulum; kinetics; metabolism; physiology; probability; statistical model; Algorithms; Buffers; Calcium; Calcium Signaling; Cell Membrane; Computer Simulation; Cytosol; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Kinetics; Models, Biological; Models, Statistical; Probability
Año:2010
Volumen:368
Número:1933
Página de inicio:5597
Página de fin:5603
DOI: http://dx.doi.org/10.1098/rsta.2010.0273
Título revista:Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Título revista abreviado:Philos. Trans. R. Soc. A Math. Phys. Eng. Sci.
ISSN:1364503X
CAS:calcium, 14092-94-5, 7440-70-2; inositol 1,4,5 trisphosphate, 85166-31-0, 88269-39-0; Buffers; Calcium, 7440-70-2; Inositol 1,4,5-Trisphosphate, 85166-31-0
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_1364503X_v368_n1933_p5597_Solovey.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1364503X_v368_n1933_p5597_Solovey

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Citas:

---------- APA ----------
Solovey, G. & Dawson, S.P. (2010) . Observable effects of Ca2+ buffers on local Ca2+ signals. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 368(1933), 5597-5603.
http://dx.doi.org/10.1098/rsta.2010.0273
---------- CHICAGO ----------
Solovey, G., Dawson, S.P. "Observable effects of Ca2+ buffers on local Ca2+ signals" . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368, no. 1933 (2010) : 5597-5603.
http://dx.doi.org/10.1098/rsta.2010.0273
---------- MLA ----------
Solovey, G., Dawson, S.P. "Observable effects of Ca2+ buffers on local Ca2+ signals" . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 368, no. 1933, 2010, pp. 5597-5603.
http://dx.doi.org/10.1098/rsta.2010.0273
---------- VANCOUVER ----------
Solovey, G., Dawson, S.P. Observable effects of Ca2+ buffers on local Ca2+ signals. Philos. Trans. R. Soc. A Math. Phys. Eng. Sci. 2010;368(1933):5597-5603.
http://dx.doi.org/10.1098/rsta.2010.0273