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Abstract:

Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling. © 2010 The Royal Society of Chemistry.

Registro:

Documento: Artículo
Título:The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer
Autor:Stojković, V.; Perissinotti, L.L.; Lee, J.; Benkovic, S.J.; Kohen, A.
Filiación:Department of Chemistry, University of Iowa, Iowa City, IA, United States
Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Ciudad Universitaria, Pabellón II piso 3, C1428EHA Buenos Aires, Argentina
Department of Chemistry, Pennsylvania State University, University Park, PA, United States
Palabras clave:alanine; dihydrofolate reductase; hydrogen; isoleucine; article; biotransformation; catalysis; chemical reaction; crystal structure; molecular dynamics; quantum mechanics; site directed mutagenesis; synthesis; Alanine; Amino Acid Substitution; Catalysis; Catalytic Domain; Escherichia coli; Isoleucine; Kinetics; Molecular Dynamics Simulation; Mutation; NADP; Tetrahydrofolate Dehydrogenase
Año:2010
Volumen:46
Número:47
Página de inicio:8974
Página de fin:8976
DOI: http://dx.doi.org/10.1039/c0cc02988b
Título revista:Chemical Communications
Título revista abreviado:Chem. Commun.
ISSN:13597345
CODEN:CHCOF
CAS:alanine, 56-41-7, 6898-94-8; dihydrofolate reductase, 9002-03-3; hydrogen, 12385-13-6, 1333-74-0; isoleucine, 7004-09-3, 73-32-5; Alanine, 56-41-7; Isoleucine, 73-32-5; NADP, 53-59-8; Tetrahydrofolate Dehydrogenase, 1.5.1.3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13597345_v46_n47_p8974_Stojkovic

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Citas:

---------- APA ----------
Stojković, V., Perissinotti, L.L., Lee, J., Benkovic, S.J. & Kohen, A. (2010) . The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer. Chemical Communications, 46(47), 8974-8976.
http://dx.doi.org/10.1039/c0cc02988b
---------- CHICAGO ----------
Stojković, V., Perissinotti, L.L., Lee, J., Benkovic, S.J., Kohen, A. "The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer" . Chemical Communications 46, no. 47 (2010) : 8974-8976.
http://dx.doi.org/10.1039/c0cc02988b
---------- MLA ----------
Stojković, V., Perissinotti, L.L., Lee, J., Benkovic, S.J., Kohen, A. "The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer" . Chemical Communications, vol. 46, no. 47, 2010, pp. 8974-8976.
http://dx.doi.org/10.1039/c0cc02988b
---------- VANCOUVER ----------
Stojković, V., Perissinotti, L.L., Lee, J., Benkovic, S.J., Kohen, A. The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer. Chem. Commun. 2010;46(47):8974-8976.
http://dx.doi.org/10.1039/c0cc02988b