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Abstract:

Tinnitus is the conscious perception of a phantom sound in the absence of an external source. For 1 in 100 of the general population, the condition severely affects quality of life. In spite of the fact that the market for a drug indicated for tinnitus relief is huge, there are still no FDA-approved drugs, and the quest for a tinnitus-targeted compound faces important challenges. A wide variety of drugs have been used off-label to treat tinnitus sufferers, with limited but significant effects in subsets of patients. If the compounds being developed at present by the pharmaceutical industry finally reach the market, they will establish a turning point in the treatment of this pathology. © 2009 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Pharmacological approaches to the treatment of tinnitus
Autor:Elgoyhen, A.B.; Langguth, B.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires 1428, Argentina
Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina
Department of Psychiatry and Psychotherapy, University of Regensburg, Interdisciplinary Tinnitus Clinic, University of Regensburg, Regensburg 93053, Germany
Palabras clave:acamprosate; alprazolam; amitriptyline; atorvastatin; benzodiazepine; carbamazepine; clonazepam; cyclandelate; diazepam; duloxetine; ebselen; furosemide; gabapentin; Ginkgo biloba extract; lamotrigine; lidocaine; memantine; misoprostol; neramexane; nimodipine; nortriptyline; paroxetine; placebo; sertraline; sulpiride; tricyclic antidepressant agent; trimipramine; unindexed drug; venlafaxine; vestipitant; clinical trial; cognitive therapy; disease severity; drug industry; ear disease; feedback system; head and neck injury; human; loudness recruitment; noise; patient counseling; prevalence; quality of life; review; risk factor; stress; tinnitus; vestibulocochlear nerve disease; visual analog scale; Animals; Drug Discovery; Drug Industry; Humans; Tinnitus
Año:2010
Volumen:15
Número:7-8
Página de inicio:300
Página de fin:305
DOI: http://dx.doi.org/10.1016/j.drudis.2009.11.003
Título revista:Drug Discovery Today
Título revista abreviado:Drug Discov. Today
ISSN:13596446
CODEN:DDTOF
CAS:acamprosate, 77337-73-6; alprazolam, 28981-97-7; amitriptyline, 50-48-6, 549-18-8; atorvastatin, 134523-00-5, 134523-03-8; benzodiazepine, 12794-10-4; carbamazepine, 298-46-4, 8047-84-5; clonazepam, 1622-61-3; cyclandelate, 456-59-7; diazepam, 439-14-5; duloxetine, 116539-59-4, 136434-34-9; ebselen, 60940-34-3; furosemide, 54-31-9; gabapentin, 60142-96-3; lamotrigine, 84057-84-1; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; memantine, 19982-08-2, 41100-52-1; misoprostol, 59122-46-2, 59122-48-4; neramexane, 209185-99-9, 219810-59-0, 457068-92-7; nimodipine, 66085-59-4; nortriptyline, 72-69-5, 894-71-3; paroxetine, 61869-08-7; sertraline, 79617-96-2; sulpiride, 15676-16-1; trimipramine, 25332-13-2, 521-78-8, 739-71-9; venlafaxine, 93413-69-5; vestipitant, 334476-64-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13596446_v15_n7-8_p300_Elgoyhen

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Citas:

---------- APA ----------
Elgoyhen, A.B. & Langguth, B. (2010) . Pharmacological approaches to the treatment of tinnitus. Drug Discovery Today, 15(7-8), 300-305.
http://dx.doi.org/10.1016/j.drudis.2009.11.003
---------- CHICAGO ----------
Elgoyhen, A.B., Langguth, B. "Pharmacological approaches to the treatment of tinnitus" . Drug Discovery Today 15, no. 7-8 (2010) : 300-305.
http://dx.doi.org/10.1016/j.drudis.2009.11.003
---------- MLA ----------
Elgoyhen, A.B., Langguth, B. "Pharmacological approaches to the treatment of tinnitus" . Drug Discovery Today, vol. 15, no. 7-8, 2010, pp. 300-305.
http://dx.doi.org/10.1016/j.drudis.2009.11.003
---------- VANCOUVER ----------
Elgoyhen, A.B., Langguth, B. Pharmacological approaches to the treatment of tinnitus. Drug Discov. Today. 2010;15(7-8):300-305.
http://dx.doi.org/10.1016/j.drudis.2009.11.003