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Abstract:

Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies. © 2013 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Vascular galectins: Regulators of tumor progression and targets for cancer therapy
Autor:Thijssen, V.L.; Rabinovich, G.A.; Griffioen, A.W.
Filiación:Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Buenos Aires, Argentina
Laboratorio de Glicómica Funcional, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:Angiogenesis; Endothelial cells; Endothelium; Immune response; Metastasis; 6 hydroxilpropylacylfulvene; anginex; antineoplastic agent; bevacizumab; ecalectin; galectin; galectin 1; galectin 10; galectin 12; galectin 13; galectin 14; galectin 2; galectin 3; galectin 4; galectin 7; galectin 8; unclassified drug; angiogenesis; breast cancer; cancer growth; cancer therapy; cell function; drug targeting; endothelium cell; human; immune response; metastasis; multiple myeloma; nonhuman; priority journal; prostate cancer; protein expression; regulatory mechanism; review; tumor escape; tumor immunity; tumor vascularization; Angiogenesis; Endothelial cells; Endothelium; Immune response; Metastasis; Animals; Disease Progression; Endothelium, Vascular; Galectins; Humans; Neoplasms
Año:2013
Volumen:24
Número:6
Página de inicio:547
Página de fin:558
DOI: http://dx.doi.org/10.1016/j.cytogfr.2013.07.003
Título revista:Cytokine and Growth Factor Reviews
Título revista abreviado:Cytokine Growth Factor Rev.
ISSN:13596101
CODEN:CGFRF
CAS:bevacizumab, 216974-75-3; galectin 1, 258495-34-0; galectin 3, 208128-56-7; galectin 8, 220452-97-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13596101_v24_n6_p547_Thijssen

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Citas:

---------- APA ----------
Thijssen, V.L., Rabinovich, G.A. & Griffioen, A.W. (2013) . Vascular galectins: Regulators of tumor progression and targets for cancer therapy. Cytokine and Growth Factor Reviews, 24(6), 547-558.
http://dx.doi.org/10.1016/j.cytogfr.2013.07.003
---------- CHICAGO ----------
Thijssen, V.L., Rabinovich, G.A., Griffioen, A.W. "Vascular galectins: Regulators of tumor progression and targets for cancer therapy" . Cytokine and Growth Factor Reviews 24, no. 6 (2013) : 547-558.
http://dx.doi.org/10.1016/j.cytogfr.2013.07.003
---------- MLA ----------
Thijssen, V.L., Rabinovich, G.A., Griffioen, A.W. "Vascular galectins: Regulators of tumor progression and targets for cancer therapy" . Cytokine and Growth Factor Reviews, vol. 24, no. 6, 2013, pp. 547-558.
http://dx.doi.org/10.1016/j.cytogfr.2013.07.003
---------- VANCOUVER ----------
Thijssen, V.L., Rabinovich, G.A., Griffioen, A.W. Vascular galectins: Regulators of tumor progression and targets for cancer therapy. Cytokine Growth Factor Rev. 2013;24(6):547-558.
http://dx.doi.org/10.1016/j.cytogfr.2013.07.003