Artículo

Blaustein, M.; Pelisch, F.; Srebrow, A. "Signals, pathways and splicing regulation" (2007) International Journal of Biochemistry and Cell Biology. 39(11):2031-2048
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Abstract:

Alternative splicing of messenger RNA precursors is an extraordinary source of protein diversity and the regulation of this process is crucial for diverse cellular functions in both physiological and pathological situations. For many years, several signaling pathways have been implicated in alternative splicing regulation. Recent work has begun to unravel the molecular mechanisms by which extracellular stimuli activate signaling cascades that modulate the activity of the splicing machinery and therefore the splicing pattern of many different target messenger RNA precursors. These experiments are revealing unexpected aspects of the mechanism that control splicing and the consequences of the regulated splicing events. We summarize here the current knowledge about signal-induced alternative splicing regulation of Slo, NR1, CD44, CD45 and fibronectin genes, and also discuss the importance of some of these events in determination of cellular fate. Furthermore, we highlight the relevance of signal-induced changes in phosphorylation state and subcellular distribution of splicing factors as a way of regulating the splicing process. Lastly, we explore new and unexpected findings about regulated splicing in anucleated cells. © 2007 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Signals, pathways and splicing regulation
Autor:Blaustein, M.; Pelisch, F.; Srebrow, A.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Pabellón 2, C1428EHA Buenos Aires, Argentina
Palabras clave:Extracellular stimuli; RNA processing; Signal transduction; Splicing; CD45 antigen; fibronectin; Hermes antigen; messenger RNA; n methyl dextro aspartic acid receptor 1; RNA precursor; alternative RNA splicing; animal cell; CD44 gene; CD45 gene; cell fate; cell function; cellular distribution; fibronectin gene; gene; molecular mechanics; nonhuman; NR1 gene; protein phosphorylation; review; RNA processing; signal detection; Slo gene; Alternative Splicing; Animals; Cell Nucleus; Humans; Models, Genetic; RNA Precursors; Signal Transduction; Subcellular Fractions
Año:2007
Volumen:39
Número:11
Página de inicio:2031
Página de fin:2048
DOI: http://dx.doi.org/10.1016/j.biocel.2007.04.004
Título revista:International Journal of Biochemistry and Cell Biology
Título revista abreviado:Int. J. Biochem. Cell Biol.
ISSN:13572725
CODEN:IJBBF
CAS:fibronectin, 86088-83-7; RNA Precursors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v39_n11_p2031_Blaustein

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Citas:

---------- APA ----------
Blaustein, M., Pelisch, F. & Srebrow, A. (2007) . Signals, pathways and splicing regulation. International Journal of Biochemistry and Cell Biology, 39(11), 2031-2048.
http://dx.doi.org/10.1016/j.biocel.2007.04.004
---------- CHICAGO ----------
Blaustein, M., Pelisch, F., Srebrow, A. "Signals, pathways and splicing regulation" . International Journal of Biochemistry and Cell Biology 39, no. 11 (2007) : 2031-2048.
http://dx.doi.org/10.1016/j.biocel.2007.04.004
---------- MLA ----------
Blaustein, M., Pelisch, F., Srebrow, A. "Signals, pathways and splicing regulation" . International Journal of Biochemistry and Cell Biology, vol. 39, no. 11, 2007, pp. 2031-2048.
http://dx.doi.org/10.1016/j.biocel.2007.04.004
---------- VANCOUVER ----------
Blaustein, M., Pelisch, F., Srebrow, A. Signals, pathways and splicing regulation. Int. J. Biochem. Cell Biol. 2007;39(11):2031-2048.
http://dx.doi.org/10.1016/j.biocel.2007.04.004