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Abstract:

Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, in the last 10 years, in vitro and in vivo studies, have demonstrated that bilirubin exhibits potent anti-oxidant properties preventing the oxidative damage triggered by a wide range of oxidant-related stimuli. Therefore, the idea of a beneficial and physiological role for bilirubin in cytoprotection against short and long-lasting oxidant-mediated cell injury is highlighted here. © 2002 Elsevier Science Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Bilirubin: Its role in cytoprotection against oxidative stress
Autor:Tomaro, M.L.; Batlle, A.M.D.C.
Filiación:Departamento De Química Biológica, Facultad De Farmacia Y Bioquímica, Universidad De Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Centro De Investigaciones Sobre Porfirinas Y Porfirias (CIPYP), CONICET-Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires, Buenos Aires, Argentina
Palabras clave:Anti-oxidant defenses; Bilirubin; Heme catabolism; Heme oxygenase; Oxidative stress; bilirubin; article; catabolism; cell damage; cell protection; chemical structure; human; mammal; oxidation; oxidative stress; physiology; Mammalia
Año:2002
Volumen:34
Número:3
Página de inicio:216
Página de fin:220
DOI: http://dx.doi.org/10.1016/S1357-2725(01)00130-3
Título revista:International Journal of Biochemistry and Cell Biology
Título revista abreviado:Int. J. Biochem. Cell Biol.
ISSN:13572725
CODEN:IJBBF
CAS:bilirubin, 18422-02-1, 635-65-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v34_n3_p216_Tomaro

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Citas:

---------- APA ----------
Tomaro, M.L. & Batlle, A.M.D.C. (2002) . Bilirubin: Its role in cytoprotection against oxidative stress. International Journal of Biochemistry and Cell Biology, 34(3), 216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3
---------- CHICAGO ----------
Tomaro, M.L., Batlle, A.M.D.C. "Bilirubin: Its role in cytoprotection against oxidative stress" . International Journal of Biochemistry and Cell Biology 34, no. 3 (2002) : 216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3
---------- MLA ----------
Tomaro, M.L., Batlle, A.M.D.C. "Bilirubin: Its role in cytoprotection against oxidative stress" . International Journal of Biochemistry and Cell Biology, vol. 34, no. 3, 2002, pp. 216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3
---------- VANCOUVER ----------
Tomaro, M.L., Batlle, A.M.D.C. Bilirubin: Its role in cytoprotection against oxidative stress. Int. J. Biochem. Cell Biol. 2002;34(3):216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3