Abstract:
Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, in the last 10 years, in vitro and in vivo studies, have demonstrated that bilirubin exhibits potent anti-oxidant properties preventing the oxidative damage triggered by a wide range of oxidant-related stimuli. Therefore, the idea of a beneficial and physiological role for bilirubin in cytoprotection against short and long-lasting oxidant-mediated cell injury is highlighted here. © 2002 Elsevier Science Ltd. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Bilirubin: Its role in cytoprotection against oxidative stress |
Autor: | Tomaro, M.L.; Batlle, A.M.D.C. |
Filiación: | Departamento De Química Biológica, Facultad De Farmacia Y Bioquímica, Universidad De Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina Centro De Investigaciones Sobre Porfirinas Y Porfirias (CIPYP), CONICET-Facultad De Ciencias Exactas Y Naturales, Universidad De Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | Anti-oxidant defenses; Bilirubin; Heme catabolism; Heme oxygenase; Oxidative stress; bilirubin; article; catabolism; cell damage; cell protection; chemical structure; human; mammal; oxidation; oxidative stress; physiology; Mammalia |
Año: | 2002
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Volumen: | 34
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Número: | 3
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Página de inicio: | 216
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Página de fin: | 220
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DOI: |
http://dx.doi.org/10.1016/S1357-2725(01)00130-3 |
Título revista: | International Journal of Biochemistry and Cell Biology
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Título revista abreviado: | Int. J. Biochem. Cell Biol.
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ISSN: | 13572725
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CODEN: | IJBBF
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CAS: | bilirubin, 18422-02-1, 635-65-4
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v34_n3_p216_Tomaro |
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Citas:
---------- APA ----------
Tomaro, M.L. & Batlle, A.M.D.C.
(2002)
. Bilirubin: Its role in cytoprotection against oxidative stress. International Journal of Biochemistry and Cell Biology, 34(3), 216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3---------- CHICAGO ----------
Tomaro, M.L., Batlle, A.M.D.C.
"Bilirubin: Its role in cytoprotection against oxidative stress"
. International Journal of Biochemistry and Cell Biology 34, no. 3
(2002) : 216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3---------- MLA ----------
Tomaro, M.L., Batlle, A.M.D.C.
"Bilirubin: Its role in cytoprotection against oxidative stress"
. International Journal of Biochemistry and Cell Biology, vol. 34, no. 3, 2002, pp. 216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3---------- VANCOUVER ----------
Tomaro, M.L., Batlle, A.M.D.C. Bilirubin: Its role in cytoprotection against oxidative stress. Int. J. Biochem. Cell Biol. 2002;34(3):216-220.
http://dx.doi.org/10.1016/S1357-2725(01)00130-3