Artículo

Caballero, F.; Gerez, E.; Oliveri, L.; Falcoff, N.; Batlle, A.; Vazquez, E. "On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice" (2001) International Journal of Biochemistry and Cell Biology. 33(7):681-690
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Abstract:

Background and aims: Tamoxifen (TMX) has proven to be an effective palliative treatment for advanced breast cancer with low reported incidence of side effects. TMX has been demonstrated to be an initiator and/or a promoter in the rat model of hepatocarcinogenesis. To document the long-term effect of TMX in mice treated with p-dimethylaminoazobenzene (DAB), we have investigated the time response action of these drugs on different biochemical parameters. Methods: A group of animals was placed on dietary DAB (0.5%, w/w) during a period of 28 weeks. Control animals received a standard laboratory diet. Two other groups of non-treated and DAB-treated animals received TMX citrate (0.025%, w/w) in the diet since day 20. Results: The activities of the enzymes involved in heme synthesis and degradation as evaluated in the DAB group was not further affected by TMX. DAB and/or TMX treatment significantly increased the content of total cytochrome P450 and also the activity of glutathione S-transferase indicating liver damage. In all treated groups oxidative stress and an adaptive response of the natural defense system (catalase and superoxide dismutase) were demonstrated. Histological and morphological studies revealed liver cell hyperplasia in DAB treated group; however, only in the DAB+TMX group solid, trabecular and acinar hepatocellular carcinoma was confirmed at the end of the experimental trial. Conclusion: We have demonstrated that TMX produced changes in hepatic enzyme activities which may be relevant for the metabolism and disposition of this and/or other drugs. Because liver tumors could be initiated and promoted by several agents which need to be activated, the possible hazard of TMX should be considered. This study reports that long-term treatment with TMX enhances hepatocarcinogenesis induced by DAB. The widespread use of TMX as an anticancer agent adds to the significance of this study. © 2001 Published by Elsevier Science Ltd.

Registro:

Documento: Artículo
Título:On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice
Autor:Caballero, F.; Gerez, E.; Oliveri, L.; Falcoff, N.; Batlle, A.; Vazquez, E.
Filiación:Centro De Investigaciones Sobre Porfirinas Y Porfirias (CIPYP) (CONICET-FCENUBA), Ciudad Universitaria, Pabellón II, 2do piso, 1428 Buenos Aires, Argentina
Department of Pathology, Hospital 'Dr Bernardo Houssay', Vicente López, Buenos Aires, Argentina
Viamonte 1881 10o 'A', C1056ABA-Buenos Aires, Argentina
Palabras clave:Cytochrome P450; Hepatocarcinogenesis; Oxidative stress; P-Dimethylaminoazobenzene; Tamoxifen; 4 dimethylaminoazobenzene; antineoplastic agent; catalase; cytochrome P450; glutathione transferase; liver enzyme; superoxide dismutase; tamoxifen; tamoxifen citrate; animal experiment; animal model; animal tissue; article; controlled study; degradation; diet; enzyme activity; heme synthesis; liver carcinogenesis; liver cell carcinoma; liver hyperplasia; liver injury; liver tumor; long term care; male; mouse; nonhuman; oxidative stress; response time; 5-Aminolevulinate Synthetase; Animals; Body Weight; Carcinogens; Catalase; Cytochrome P-450 Enzyme System; Glutathione Transferase; Heme Oxygenase (Decyclizing); Liver; Liver Neoplasms, Experimental; Male; Mice; Organ Size; p-Dimethylaminoazobenzene; Superoxide Dismutase; Tamoxifen; Thiobarbituric Acid Reactive Substances; Time Factors; Animalia
Año:2001
Volumen:33
Número:7
Página de inicio:681
Página de fin:690
DOI: http://dx.doi.org/10.1016/S1357-2725(01)00056-5
Título revista:International Journal of Biochemistry and Cell Biology
Título revista abreviado:Int. J. Biochem. Cell Biol.
ISSN:13572725
CODEN:IJBBF
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Carcinogens; Catalase, EC 1.11.1.6; Cytochrome P-450 Enzyme System, 9035-51-2; Glutathione Transferase, EC 2.5.1.18; Heme Oxygenase (Decyclizing), EC 1.14.99.3; p-Dimethylaminoazobenzene, 60-11-7; Superoxide Dismutase, EC 1.15.1.1; Tamoxifen, 10540-29-1; Thiobarbituric Acid Reactive Substances
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v33_n7_p681_Caballero

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Citas:

---------- APA ----------
Caballero, F., Gerez, E., Oliveri, L., Falcoff, N., Batlle, A. & Vazquez, E. (2001) . On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice. International Journal of Biochemistry and Cell Biology, 33(7), 681-690.
http://dx.doi.org/10.1016/S1357-2725(01)00056-5
---------- CHICAGO ----------
Caballero, F., Gerez, E., Oliveri, L., Falcoff, N., Batlle, A., Vazquez, E. "On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice" . International Journal of Biochemistry and Cell Biology 33, no. 7 (2001) : 681-690.
http://dx.doi.org/10.1016/S1357-2725(01)00056-5
---------- MLA ----------
Caballero, F., Gerez, E., Oliveri, L., Falcoff, N., Batlle, A., Vazquez, E. "On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice" . International Journal of Biochemistry and Cell Biology, vol. 33, no. 7, 2001, pp. 681-690.
http://dx.doi.org/10.1016/S1357-2725(01)00056-5
---------- VANCOUVER ----------
Caballero, F., Gerez, E., Oliveri, L., Falcoff, N., Batlle, A., Vazquez, E. On the promoting action of tamoxifen in a model of hepatocarcinogenesis induced by p-dimethylaminoazobenzene in CF1 mice. Int. J. Biochem. Cell Biol. 2001;33(7):681-690.
http://dx.doi.org/10.1016/S1357-2725(01)00056-5