Artículo

Billi De Catabbi, S.; Sterin-Speziale, N.; Fernandez, M.C.; Minutolo, C.; Aldonatti, C.; San Martin De Viale, L. "Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria" (1997) International Journal of Biochemistry and Cell Biology. 29(2):335-344
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Abstract:

A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated as related to changes in porphyrin metabolism with the aim to understand better the interregulation of both metabolisms. Female Wistar rats were treated with HCB (1 g/kg) over a 1-8 week period. Individual phospholipid content, [32P] incorporation, total lipid content, lipid peroxidation, uroporphyrinogen decarboxylase activity, its inhibitor generation and porphyrin content, were the parameters measured in the liver of treated rats. Phospholipid metabolism - with the exception of sphingomyelin-presents a biphasic behaviour, in both the endogenous contents and de novo synthesis. The turning point between both phases is the time at which levels of porphyrin and conjugated dienes increase, the latter compounds being involved in oxidative processes. On the other hand, sphingomyelin decreases continuously during the 8 weeks of treatment. It mas also found that the malondialdehyde content increased during the early stages. The time sequence for haem metabolism parameters showed that the accumulation of porphyrins occurs after the decrease in uroporphyrinogen decarboxylase activity and the enzyme inhibitor formation, which are early events (first and second weeks). Porphyrins could not by themselves exacerbate uroporphyrinogen decarboxylase impairment or inhibitor generation. This study shows that hexachlorobenzene alters simultaneously phospholipid and porphyrin metabolisms from the early stages, and generates an oxidative environment that favours porphyrinogens and lipid oxidation at later stages. So, this oxidative environment links the alterations on both metabolisms.

Registro:

Documento: Artículo
Título:Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
Autor:Billi De Catabbi, S.; Sterin-Speziale, N.; Fernandez, M.C.; Minutolo, C.; Aldonatti, C.; San Martin De Viale, L.
Filiación:Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Fac. de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
O'Higgins 4332, Capital 1429, Buenos Aires, Argentina
Palabras clave:Hexachlorobenzene; Lipid peroxidation; Phospholipid; Porphyria; Porphyrins; hexachlorobenzene; phospholipid; porphyrin; uroporphyrinogen decarboxylase; animal model; article; controlled study; female; lipid peroxidation; nonhuman; phospholipid metabolism; porphyria; porphyrin metabolism; rat; Animals; Female; Fungicides, Industrial; Hexachlorobenzene; Lipid Metabolism; Lipid Peroxidation; Porphyrias; Rats; Rats, Wistar; Animalia; Rattus norvegicus
Año:1997
Volumen:29
Número:2
Página de inicio:335
Página de fin:344
DOI: http://dx.doi.org/10.1016/S1357-2725(96)00096-9
Título revista:International Journal of Biochemistry and Cell Biology
Título revista abreviado:INT. J. BIOCHEM. CELL BIOL.
ISSN:13572725
CODEN:IJBBF
CAS:Fungicides, Industrial; Hexachlorobenzene, 118-74-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v29_n2_p335_BilliDeCatabbi

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Citas:

---------- APA ----------
Billi De Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., Aldonatti, C. & San Martin De Viale, L. (1997) . Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria. International Journal of Biochemistry and Cell Biology, 29(2), 335-344.
http://dx.doi.org/10.1016/S1357-2725(96)00096-9
---------- CHICAGO ----------
Billi De Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., Aldonatti, C., San Martin De Viale, L. "Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria" . International Journal of Biochemistry and Cell Biology 29, no. 2 (1997) : 335-344.
http://dx.doi.org/10.1016/S1357-2725(96)00096-9
---------- MLA ----------
Billi De Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., Aldonatti, C., San Martin De Viale, L. "Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria" . International Journal of Biochemistry and Cell Biology, vol. 29, no. 2, 1997, pp. 335-344.
http://dx.doi.org/10.1016/S1357-2725(96)00096-9
---------- VANCOUVER ----------
Billi De Catabbi, S., Sterin-Speziale, N., Fernandez, M.C., Minutolo, C., Aldonatti, C., San Martin De Viale, L. Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria. INT. J. BIOCHEM. CELL BIOL. 1997;29(2):335-344.
http://dx.doi.org/10.1016/S1357-2725(96)00096-9