Artículo

Barrientos, G.; Freitag, N.; Tirado-González, I.; Unverdorben, L.; Jeschke, U.; Thijssen, V.L.J.L.; Blois, S.M. "Involvement of galectin-1 in reproduction: Past, present and future" (2014) Human Reproduction Update. 20(2):175-193
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Abstract:

background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal-maternal interface, many functional aspects of this lectin in reproduction are only emerging. methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal-fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation.We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytiumformation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy. © The Author 2013.

Registro:

Documento: Artículo
Título:Involvement of galectin-1 in reproduction: Past, present and future
Autor:Barrientos, G.; Freitag, N.; Tirado-González, I.; Unverdorben, L.; Jeschke, U.; Thijssen, V.L.J.L.; Blois, S.M.
Filiación:CharitéCenter 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitätsmedizin Berlin, Berlin, Germany
Laboratorio de Fisiología Molecular Placentaria, Instituto de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina
Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University of Munich, Campus Innenstadt, Maistrasse 11, 80337 Munich, Germany
Departments of Radiation Oncology and Medical Oncology, Angiogenesis Laboratory, VU University Medical Center, Amsterdam, Netherlands
Palabras clave:Angiogenesis; Cancer; Galectin-1; Pregnancy; Progesterone; angiogenesis; cancer; galectin-1; pregnancy; progesterone; Adaptation, Physiological; Animals; Female; Galectin 1; Genital Neoplasms, Female; Genitalia, Female; Humans; Immune Tolerance; Mice; Neovascularization, Physiologic; Pregnancy; Pregnancy Complications; Reproduction; Signal Transduction; Trophoblasts
Año:2014
Volumen:20
Número:2
Página de inicio:175
Página de fin:193
DOI: http://dx.doi.org/10.1093/humupd/dmt040
Título revista:Human Reproduction Update
Título revista abreviado:Hum. Reprod. Update
ISSN:13554786
CODEN:HRUPF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13554786_v20_n2_p175_Barrientos

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Citas:

---------- APA ----------
Barrientos, G., Freitag, N., Tirado-González, I., Unverdorben, L., Jeschke, U., Thijssen, V.L.J.L. & Blois, S.M. (2014) . Involvement of galectin-1 in reproduction: Past, present and future. Human Reproduction Update, 20(2), 175-193.
http://dx.doi.org/10.1093/humupd/dmt040
---------- CHICAGO ----------
Barrientos, G., Freitag, N., Tirado-González, I., Unverdorben, L., Jeschke, U., Thijssen, V.L.J.L., et al. "Involvement of galectin-1 in reproduction: Past, present and future" . Human Reproduction Update 20, no. 2 (2014) : 175-193.
http://dx.doi.org/10.1093/humupd/dmt040
---------- MLA ----------
Barrientos, G., Freitag, N., Tirado-González, I., Unverdorben, L., Jeschke, U., Thijssen, V.L.J.L., et al. "Involvement of galectin-1 in reproduction: Past, present and future" . Human Reproduction Update, vol. 20, no. 2, 2014, pp. 175-193.
http://dx.doi.org/10.1093/humupd/dmt040
---------- VANCOUVER ----------
Barrientos, G., Freitag, N., Tirado-González, I., Unverdorben, L., Jeschke, U., Thijssen, V.L.J.L., et al. Involvement of galectin-1 in reproduction: Past, present and future. Hum. Reprod. Update. 2014;20(2):175-193.
http://dx.doi.org/10.1093/humupd/dmt040