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Shan, B.; Gerez, J.; Haedo, M.; Fuertes, M.; Theodoropoulou, M.; Buchfelder, M.; Losa, M.; Stalla, G.K.; Arzt, E.; Renner, U. "RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells" (2012) Endocrine-Related Cancer. 19(1):13-27
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Abstract:

The recently cloned small RWD-domain containing protein RSUME was shown to increase protein levels of hypoxia-inducible factor-1α (HIF-1α). The latter is the oxygen-regulated subunit of HIF-1, the most important transcription factor of the cellular adaptive processes to hypoxic conditions. It is also a major regulator of vascular endothelial growth factor-A (VEGF-A), which is critically involved in the complex process of tumour neovascularisation. In this study, the expression and role of RSUME in pituitary tumours was studied. We found that RSUME mRNA was up-regulated in pituitary adenomas and significantly correlated with HIF-1α mRNA levels. Hypoxia (1% O 2) or treatment with hypoxia-mimicking CoCl 2 enhanced RSUME and HIF-1α expression, induced translocation of HIF-1α to the nuclei and stimulated VEGF-A production both in pituitary tumour cell lines and primary human pituitary adenoma cell cultures. When RSUME expression was specifically down-regulated by siRNA, the CoCl 2-induced increase VEGF-A secretion was strongly reduced which was shown to be a consequence of the RSUME knockdown-associated reduction of HIF-1α synthesis. Thus, RSUME plays an important role in initiating pituitary tumour neovascularisation through regulating HIF-1α levels and subsequent VEGF-A production and may therefore be critically involved in pituitary adenoma progression. © 2012 Society for Endocrinology Printed in Great Britain.

Registro:

Documento: Artículo
Título:RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells
Autor:Shan, B.; Gerez, J.; Haedo, M.; Fuertes, M.; Theodoropoulou, M.; Buchfelder, M.; Losa, M.; Stalla, G.K.; Arzt, E.; Renner, U.
Filiación:Neuroendocrinology Group, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany
Departamento de Fisiología Y Biología Molecular Y Celular, Universidad de Buenos Aires, Instituto de Investigacion Biomedicina de Buenos Aires (IBioBA), 1428 Buenos Aires, Argentina
Neurosurgical Clinic, University of Erlangen-Nuremburg, D-91054 Erlangen, Germany
Department of Neurosurgery, Istituto San Raffaele, I-20132 Milano, Italy
Palabras clave:cobalt chloride; hypoxia inducible factor 1alpha; messenger RNA; protein; protein RSUME; small interfering RNA; unclassified drug; vasculotropin A; cobalt; HIF1A protein, human; hypoxia inducible factor 1alpha; messenger RNA; RSUME protein, human; transcription factor; vasculotropin A; VEGFA protein, human; article; cancer cell culture; cell nucleus; controlled study; correlation analysis; down regulation; human; human cell; human tissue; hypophysis adenoma; hypoxia; protein expression; protein function; protein induction; protein secretion; protein transport; RNA interference; upregulation; adenoma; animal; anoxia; biosynthesis; genetics; hypophysis tumor; metabolism; mouse; neovascularization (pathology); tumor cell culture; tumor cell line; Adenoma; Animals; Anoxia; Cell Line, Tumor; Cobalt; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Pathologic; Pituitary Neoplasms; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A
Año:2012
Volumen:19
Número:1
Página de inicio:13
Página de fin:27
DOI: http://dx.doi.org/10.1530/ERC-11-0211
Título revista:Endocrine-Related Cancer
Título revista abreviado:Endocr.-Relat. Cancer
ISSN:13510088
CODEN:ERCAE
CAS:cobalt chloride, 1332-82-7, 7646-79-9; protein, 67254-75-5; vasculotropin A, 489395-96-2; cobalt, 7440-48-4; Cobalt, 7440-48-4; HIF1A protein, human; Hypoxia-Inducible Factor 1, alpha Subunit; RNA, Messenger; RSUME protein, human; Transcription Factors; VEGFA protein, human; Vascular Endothelial Growth Factor A; cobaltous chloride, 7646-79-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13510088_v19_n1_p13_Shan

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Citas:

---------- APA ----------
Shan, B., Gerez, J., Haedo, M., Fuertes, M., Theodoropoulou, M., Buchfelder, M., Losa, M.,..., Renner, U. (2012) . RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocrine-Related Cancer, 19(1), 13-27.
http://dx.doi.org/10.1530/ERC-11-0211
---------- CHICAGO ----------
Shan, B., Gerez, J., Haedo, M., Fuertes, M., Theodoropoulou, M., Buchfelder, M., et al. "RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells" . Endocrine-Related Cancer 19, no. 1 (2012) : 13-27.
http://dx.doi.org/10.1530/ERC-11-0211
---------- MLA ----------
Shan, B., Gerez, J., Haedo, M., Fuertes, M., Theodoropoulou, M., Buchfelder, M., et al. "RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells" . Endocrine-Related Cancer, vol. 19, no. 1, 2012, pp. 13-27.
http://dx.doi.org/10.1530/ERC-11-0211
---------- VANCOUVER ----------
Shan, B., Gerez, J., Haedo, M., Fuertes, M., Theodoropoulou, M., Buchfelder, M., et al. RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr.-Relat. Cancer. 2012;19(1):13-27.
http://dx.doi.org/10.1530/ERC-11-0211