Abstract:
Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency was induced by surgical procedures and control rats were sham operated. Twenty-four rats were allocated to four groups of six rats each: (A) Sham; (B) Sham+Al; (C) CRF; and (D) CRF+Al. The groups B and D received daily doses of Al citrate (0.5 μmol/g bodyweight) and the groups A and C, deionized water, via the intragastric route. At the end of the experimental period (15 weeks) cultures of late erythroid progenitor cells (CFU-E) stimulated with erythropoietin were performed and haematological parameters determined. The liver, kidney, brain, bone and serum Al amounts were quantified. The results are expressed as median and interquartile range. The CFU-E growth was found inhibited in B and D groups (A: 100; B: 74/54-83; C: 86/54-98; D: 46/39-53 %). The haematocrit values were significantly diminished in rats with renal insufficiency when compared to controls (A: 42/40-43; B: 45/42-46; C: 37/32-40 and D: 37/24-39 %). Serum Al accumulation was observed in B and D groups receiving Al (A: 8/5-12; B: 36/36-44; C: 5/5- 6; D: 45126-132 μg Al]l). No differences among groups were found in the liver and kidney Al contents, but uraemic state favoured Al accumulation in brain (A: 6/5.0-9.0; B: 4/3.8-4.3; C: 2/2.0-3.0; D: 15/12.0-21.0 μg Al/g tissue) and bone (A: 29/27-31; B: 30/29-39; C: 42/33-48; D: 68/56-79 μg Al/g tissue). We suggest that the heavy accumulation of Al in the bone compartment may result in a protracted endogenous exposure of bone marrow cells, affecting the erythropoiesis in vive.
Registro:
Documento: |
Artículo
|
Título: | Aluminium accumulation in chronic renal failure affects erythropoises |
Autor: | Nesse, A.; Garbossa, G.; Stripeikis, J.; Gálvez, G.; Castro, M.E.; Rizzo, N.; Lauricella, A.M.; Gutnisky, A. |
Filiación: | Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Depto. de Quim. Inorgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Ctro. Estud. Farmacologicos y B., Consejo Nac. de Invest. Cie. y Tec., Buenos Aires, Argentina Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, Piso 4, (1428) Buenos Aires, Argentina
|
Palabras clave: | Aluminium and erythropoiesis; Aluminum; Aluminum toxicity; Chronic renal failure; aluminum citrate; animal experiment; animal model; animal tissue; article; bone; brain; chronic kidney failure; controlled study; erythropoiesis; kidney; liver; male; nonhuman; priority journal; rat; serum; tissue distribution; toxicity testing |
Año: | 1997
|
Volumen: | 3
|
Número: | 4
|
Página de inicio: | 347
|
Página de fin: | 351
|
Título revista: | Nephrology
|
Título revista abreviado: | NEPHROLOGY
|
ISSN: | 13205358
|
CODEN: | NEPHF
|
CAS: | aluminum citrate, 31142-56-0
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse |
Referencias:
- Alfrey, A.C., Le Gendre, G.R., Kaehny, W.D., The dialysis encephalopathy syndrome. Possible aluminum intoxication (1976) N. Engl. J. Med., 294, pp. 184-188
- Kaehny, W.D., Hegg, A.P., Alfrey, A.C., Gastrointestinal absorption of aluminum from aluminum-containing antacids (1977) N. Engl. J. Med., 296, pp. 1389-1390
- Nordal, K.P., Dahl, E., Halse, J., Aksnes, L., Thomassen, Y., Flatmark, A., Aluminum metabolism and bone histology after kidney transplantation: A one-year follow-up study (1992) J. Clin. Endocrinol. Metab., 74, pp. 1140-1145
- O'Hare, J.A., Murnaghan, D.J., Reversal of aluminum-induced hemodialysis anemia by a low-aluminum dialysate (1982) N. Engl. J. Med., 306, pp. 654-656
- Wills, M.R., Savory, J., Aluminum poisoning. Dialysis encephalopathy, osteomalacia, and anemia (1983) Lancet, 2, pp. 29-34
- Cannata, J.B., Briggs, J.D., Junor, B.J.R., Fell, G.S., Beastall, G., Effect of aluminium overload on calcium and parathyroid-hormone metabolism (1983) Lancet, 1, pp. 501-503
- Joffe, P., Olsen, F., Heaf, J.G., Gammelgaard, B., Pödenphant, J., Aluminum concentrations in serum, dialysate, urine and bone among patients undergoing continuous ambulatory peritoneal dialysis (CAPD) (1989) Clin. Nephrol, 32, pp. 133-138
- Arieff, A.I., Cooper, J.D., Armstrong, D., Lazarowitz, V.C., Dementia, renal failure, and brain aluminum (1979) Ann. Intern. Med., 90, pp. 741-747
- Lin, J.-L., Lim, P.-S., Leu, M.-L., Relationship of body iron status and serum aluminum in chronic renal insufficiency patients not taking any aluminum-containing drugs (1995) Am. J. Nephrol., 15, pp. 118-122
- Poisson, M., Mashaly, R., Lebkiri, B., Dialysis encephalopathy: Recovery after interruption of aluminum intake (1978) Br. Med. J., 4, pp. 1610-1611
- Smith, P.S., McClure, J., Localization of aluminium by histochemical and electron probe X-ray microanalytical techniques in bone tissue of cases of renal osteodystrophy (1982) J. Clin. Pathol., 35, pp. 1283-1293
- Ellis, H.A., McCarthy, J.H., Herrington, J., Bone aluminium in haemodialysed patients and in rats injected with aluminium chloride: Relationship to impaired bone mineralization (1979) J. Clin. Pathol., 32, pp. 832-844
- Sherrard, D.J., Hercz, G., Pei, Y., The spectrum of bone disease in end-stage renal failure. An evolving disorder (1993) Kidney Int., 43, pp. 436-442
- Maloney, N.A., Ott, S.M., Alfrey, A.C., Miller, N.L., Coburn, J.W., Sherrard, D.J., Histological quantitation of aluminium in iliac bone from patients with renal failure (1982) J. Lab. Clin. Med., 99, pp. 206-216
- Bia, M.J., Cooper, K., Schnall, S., Aluminum induced anemia: Pathogenesis and treatment in patients on chronic hemodialysis (1989) Kidney Int., 36, pp. 852-858
- Eschbach, J.W., Adamson, J.W., Anemia in renal disease (1994) Diseases of the Kidney, pp. 2743-2758. , Schrier RW, Gottschalk CW (eds.) Little, Brown & Co., Boston
- Varet, B., Casadevall, N., Lacombe, C., Nayeaux, P., Erythropoietin: Physiology and Clinical Experience (1990) Semin. Hematol., 27, pp. 25-31
- Garbossa, G., Gutnisky, A., Nesse, A., Depressed erythroid progenitor cell activity in aluminum-overloaded mice (1996) Miner. Electrolyte Metab., 22, pp. 214-218
- Touam, M., Martínez, F., Lacour, B., Aluminium-induced reversible microcytic anemia in experimental chronic renal failure: Clinical and experimental studies (1983) Clin. Nephrol., 19, pp. 295-298
- Kaiser, L., Schwartz, K.A., Burnatowska-Hledin, M.A., Mayor, G.H., Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats (1984) Kidney Int., 26, pp. 269-274
- Garbossa, G., Gutnisky, A., Nesse, A., The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- And transferrin-mediated mechanism (1994) Miner. Electrolyte Metab., 20, pp. 141-146
- Mladenovic, J., Aluminum inhibits erythropoiesis in vitro (1988) J. Clin. Invest., 81, pp. 1661-1665
- Moody, J.R., Lindstrom, R.M., Selection and cleaning of plastic containers for storage of trace element samples (1977) Anal. Chem., 49, pp. 2264-2267
- Ormrod, D., Miller, T., Experimental uremia. Description of a model producing varying degrees of stable uremia (1980) Nephron, 26, pp. 249-254
- Velarde, F., Monge, C., Vidal, A., Carcagno, M., Criscuolo, M., Bozzini, C., Serum immunoreactive erythropoietin in high altitude natives with and without excessive erythrocytosis (1991) Exp. Hematol., 19, pp. 257-260
- Drüeke, T., Lacour, B., Touam, M., Basile, C., Bourdon, R., Oral aluminum administration to uremic, hyperparathyroid, or vitamin D-supplemented rats (1985) Nephron, 39, pp. 10-17
- Recker, R., Blotcky, A.J., Leffler, J.A., Rack, E.P., Evidence for aluminum absorption from the gastrointestinal tract and bone deposition by aluminum carbonate ingestion with normal real function (1977) J. Lab. Clin. Med., 90, pp. 810-815
- Kaye, M., Bone marrow aluminium storage in renal failure (1983) J. Clin. Pathol., 36, pp. 1288-1291
- Drücke, T.B., Lacour, B., Touam, M., Effect of aluminum on hematopoiesis (1986) Kidney Int., 29 (18 SUPPL.), pp. S45-8
- Alfrey, A.C., Phosphate, aluminum, and other elements in chronic renal disease (1994) Diseases of the Kidney, pp. 3153-3166. , Schrier RW, Gottschalk CW (eds). Little Brown 6k Co., Boston
- Mera, S.L., Aluminium, amyloid, and Alzheimer's disease (1991) Med. Labor. Sci., 48, pp. 283-295
- Goodman, W.G., Leite Duarte, M.E., Aluminum: Effects on bone and role in the pathogenesis of renal osteodystrophy (1991) Miner. Electrolyte Metab., 17, pp. 221-232
Citas:
---------- APA ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., Lauricella, A.M.,..., Gutnisky, A.
(1997)
. Aluminium accumulation in chronic renal failure affects erythropoises. Nephrology, 3(4), 347-351.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]
---------- CHICAGO ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., et al.
"Aluminium accumulation in chronic renal failure affects erythropoises"
. Nephrology 3, no. 4
(1997) : 347-351.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]
---------- MLA ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., et al.
"Aluminium accumulation in chronic renal failure affects erythropoises"
. Nephrology, vol. 3, no. 4, 1997, pp. 347-351.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]
---------- VANCOUVER ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., et al. Aluminium accumulation in chronic renal failure affects erythropoises. NEPHROLOGY. 1997;3(4):347-351.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]