Artículo

Nesse, A.; Garbossa, G.; Stripeikis, J.; Gálvez, G.; Castro, M.E.; Rizzo, N.; Lauricella, A.M.; Gutnisky, A. "Aluminium accumulation in chronic renal failure affects erythropoises" (1997) Nephrology. 3(4):347-351
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Abstract:

Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency was induced by surgical procedures and control rats were sham operated. Twenty-four rats were allocated to four groups of six rats each: (A) Sham; (B) Sham+Al; (C) CRF; and (D) CRF+Al. The groups B and D received daily doses of Al citrate (0.5 μmol/g bodyweight) and the groups A and C, deionized water, via the intragastric route. At the end of the experimental period (15 weeks) cultures of late erythroid progenitor cells (CFU-E) stimulated with erythropoietin were performed and haematological parameters determined. The liver, kidney, brain, bone and serum Al amounts were quantified. The results are expressed as median and interquartile range. The CFU-E growth was found inhibited in B and D groups (A: 100; B: 74/54-83; C: 86/54-98; D: 46/39-53 %). The haematocrit values were significantly diminished in rats with renal insufficiency when compared to controls (A: 42/40-43; B: 45/42-46; C: 37/32-40 and D: 37/24-39 %). Serum Al accumulation was observed in B and D groups receiving Al (A: 8/5-12; B: 36/36-44; C: 5/5- 6; D: 45126-132 μg Al]l). No differences among groups were found in the liver and kidney Al contents, but uraemic state favoured Al accumulation in brain (A: 6/5.0-9.0; B: 4/3.8-4.3; C: 2/2.0-3.0; D: 15/12.0-21.0 μg Al/g tissue) and bone (A: 29/27-31; B: 30/29-39; C: 42/33-48; D: 68/56-79 μg Al/g tissue). We suggest that the heavy accumulation of Al in the bone compartment may result in a protracted endogenous exposure of bone marrow cells, affecting the erythropoiesis in vive.

Registro:

Documento: Artículo
Título:Aluminium accumulation in chronic renal failure affects erythropoises
Autor:Nesse, A.; Garbossa, G.; Stripeikis, J.; Gálvez, G.; Castro, M.E.; Rizzo, N.; Lauricella, A.M.; Gutnisky, A.
Filiación:Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Depto. de Quim. Inorgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Ctro. Estud. Farmacologicos y B., Consejo Nac. de Invest. Cie. y Tec., Buenos Aires, Argentina
Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, Piso 4, (1428) Buenos Aires, Argentina
Palabras clave:Aluminium and erythropoiesis; Aluminum; Aluminum toxicity; Chronic renal failure; aluminum citrate; animal experiment; animal model; animal tissue; article; bone; brain; chronic kidney failure; controlled study; erythropoiesis; kidney; liver; male; nonhuman; priority journal; rat; serum; tissue distribution; toxicity testing
Año:1997
Volumen:3
Número:4
Página de inicio:347
Página de fin:351
Título revista:Nephrology
Título revista abreviado:NEPHROLOGY
ISSN:13205358
CODEN:NEPHF
CAS:aluminum citrate, 31142-56-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse

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Citas:

---------- APA ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., Lauricella, A.M.,..., Gutnisky, A. (1997) . Aluminium accumulation in chronic renal failure affects erythropoises. Nephrology, 3(4), 347-351.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]
---------- CHICAGO ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., et al. "Aluminium accumulation in chronic renal failure affects erythropoises" . Nephrology 3, no. 4 (1997) : 347-351.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]
---------- MLA ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., et al. "Aluminium accumulation in chronic renal failure affects erythropoises" . Nephrology, vol. 3, no. 4, 1997, pp. 347-351.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]
---------- VANCOUVER ----------
Nesse, A., Garbossa, G., Stripeikis, J., Gálvez, G., Castro, M.E., Rizzo, N., et al. Aluminium accumulation in chronic renal failure affects erythropoises. NEPHROLOGY. 1997;3(4):347-351.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse [ ]