Artículo
Abstract:
BACKGROUND: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. OBJECTIVE: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. RESULTS: Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. CONCLUSIONS: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease.
Registro:
| Documento: | Artículo |
| Título: | The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. |
| Autor: | Méndez, M.; Rossetti, M.V.; Del C Batlle, A.M.; Parera, V.E. |
| Filiación: | National Research Institute on Porphyrins and Porphyrias (CIPYP), School of Sciences (FCEyN), University of Buenos Aires (UBA), and the Argentine National Research Council (CONICET), Buenos Aires, Argentina |
| Palabras clave: | hepatitis C antibody; HFE protein, human; HLA antigen class 1; membrane protein; uroporphyrinogen decarboxylase; adolescent; adult; aged; Argentina; article; blood; child; epidemiology; female; genetics; hepatitis C; human; male; metabolism; middle aged; mutation; onset age; pathophysiology; porphyria cutanea tarda; retrospective study; risk factor; Adolescent; Adult; Age of Onset; Aged; Argentina; Child; Female; Hepatitis C; Hepatitis C Antibodies; Histocompatibility Antigens Class I; Humans; Male; Membrane Proteins; Middle Aged; Mutation; Porphyria Cutanea Tarda; Precipitating Factors; Retrospective Studies; Risk Factors; Uroporphyrinogen Decarboxylase |
| Año: | 2005 |
| Volumen: | 52 |
| Número: | 3 Pt 1 |
| Página de inicio: | 417 |
| Página de fin: | 424 |
| Título revista: | Journal of the American Academy of Dermatology |
| Título revista abreviado: | J. Am. Acad. Dermatol. |
| ISSN: | 10976787 |
| CAS: | uroporphyrinogen decarboxylase, 9024-70-8; Hepatitis C Antibodies; HFE protein, human; Histocompatibility Antigens Class I; Membrane Proteins; Uroporphyrinogen Decarboxylase, EC 4.1.1.37 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976787_v52_n3Pt1_p417_Mendez |
Citas:
---------- APA ----------
Méndez, M., Rossetti, M.V., Del C Batlle, A.M. & Parera, V.E. (2005) . The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. Journal of the American Academy of Dermatology, 52(3 Pt 1), 417-424.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976787_v52_n3Pt1_p417_Mendez [ ]
---------- CHICAGO ----------
Méndez, M., Rossetti, M.V., Del C Batlle, A.M., Parera, V.E. "The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population." Journal of the American Academy of Dermatology 52, no. 3 Pt 1 (2005) : 417-424.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976787_v52_n3Pt1_p417_Mendez [ ]
---------- MLA ----------
Méndez, M., Rossetti, M.V., Del C Batlle, A.M., Parera, V.E. "The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population." Journal of the American Academy of Dermatology, vol. 52, no. 3 Pt 1, 2005, pp. 417-424.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976787_v52_n3Pt1_p417_Mendez [ ]
---------- VANCOUVER ----------
Méndez, M., Rossetti, M.V., Del C Batlle, A.M., Parera, V.E. The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population. J. Am. Acad. Dermatol. 2005;52(3 Pt 1):417-424.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976787_v52_n3Pt1_p417_Mendez [ ]
