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Bekinschtein, T.A.; Shalom, D.E.; Forcato, C.; Herrera, M.; Coleman, M.R.; Manes, F.F.; Sigman, M. "Classical conditioning in the vegetative and minimally conscious state" (2009) Nature Neuroscience. 12(10):1343-1349
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Abstract:

Pavlovian trace conditioning depends on the temporal gap between the conditioned and unconditioned stimuli. It requires, in mammals, functional medial temporal lobe structures and, in humans, explicit knowledge of the temporal contingency. It is therefore considered to be a plausible objective test to assess awareness without relying on explicit reports. We found that individuals with disorders of consciousness (DOCs), despite being unable to report awareness explicitly, were able to learn this procedure. Learning was specific and showed an anticipatory electromyographic response to the aversive conditioning stimulus, which was substantially stronger than to the control stimulus and was augmented as the aversive stimulus approached. The amount of learning correlated with the degree of cortical atrophy and was a good indicator of recovery. None of these effects were observed in control subjects under the effect of anesthesia (propofol). Our results suggest that individuals with DOCs might have partially preserved conscious processing, which cannot be mediated by explicit reports and is not detected by behavioral assessment.

Registro:

Documento: Artículo
Título:Classical conditioning in the vegetative and minimally conscious state
Autor:Bekinschtein, T.A.; Shalom, D.E.; Forcato, C.; Herrera, M.; Coleman, M.R.; Manes, F.F.; Sigman, M.
Filiación:Institute of Cognitive Neurology, Buenos Aires, Argentina
Impaired Consciousness Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
Raul Carrea Institute, Buenos Aires, Argentina
Institute of Neuroscience, Favaloro Foundation, Buenos Aires, Argentina
Laboratory of Integrative Neuroscience, Physics Department, University of Buenos Aires, Argentina
Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom
Palabras clave:adult; article; auditory stimulation; aversive behavior; brain atrophy; brain region; clinical article; conditioned reflex; consciousness disorder; controlled study; electromyography; event related potential; human; learning; priority journal; Acoustic Stimulation; Adult; Analysis of Variance; Attention; Avoidance Learning; Awareness; Blinking; Conditioning, Classical; Consciousness Disorders; Contingent Negative Variation; Electromyography; Evoked Potentials; Female; Humans; Male; Middle Aged; Psychoacoustics; Reaction Time; Young Adult
Año:2009
Volumen:12
Número:10
Página de inicio:1343
Página de fin:1349
DOI: http://dx.doi.org/10.1038/nn.2391
Título revista:Nature Neuroscience
Título revista abreviado:Nat. Neurosci.
ISSN:10976256
CODEN:NANEF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10976256_v12_n10_p1343_Bekinschtein

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Citas:

---------- APA ----------
Bekinschtein, T.A., Shalom, D.E., Forcato, C., Herrera, M., Coleman, M.R., Manes, F.F. & Sigman, M. (2009) . Classical conditioning in the vegetative and minimally conscious state. Nature Neuroscience, 12(10), 1343-1349.
http://dx.doi.org/10.1038/nn.2391
---------- CHICAGO ----------
Bekinschtein, T.A., Shalom, D.E., Forcato, C., Herrera, M., Coleman, M.R., Manes, F.F., et al. "Classical conditioning in the vegetative and minimally conscious state" . Nature Neuroscience 12, no. 10 (2009) : 1343-1349.
http://dx.doi.org/10.1038/nn.2391
---------- MLA ----------
Bekinschtein, T.A., Shalom, D.E., Forcato, C., Herrera, M., Coleman, M.R., Manes, F.F., et al. "Classical conditioning in the vegetative and minimally conscious state" . Nature Neuroscience, vol. 12, no. 10, 2009, pp. 1343-1349.
http://dx.doi.org/10.1038/nn.2391
---------- VANCOUVER ----------
Bekinschtein, T.A., Shalom, D.E., Forcato, C., Herrera, M., Coleman, M.R., Manes, F.F., et al. Classical conditioning in the vegetative and minimally conscious state. Nat. Neurosci. 2009;12(10):1343-1349.
http://dx.doi.org/10.1038/nn.2391