Artículo

Llambías, E.B.C.; Mazzetti, M.B.; Lelli, S.M.; Aldonatti, C.; De Viale, L.C.S.M. "Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria" (2007) International Journal of Toxicology. 26(6):545-551
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Abstract:

Hexachlorobenzene produces an experimental hepatic porphyria in rats, which is similar to human porphyria cutanea tarda, with hyperpigmentation as one of its characteristic features. Alterations in tryptophan metabolism have been previously observed in this chronic porphyria. Melatonin formation from tryptophan via serotonin shows diurnal rhythmicity in the pineal gland, and higher values are observed during the dark phase of an imposed light-dark cycle. The purpose of this study was to determine the contents of tryptophan and its metabolites in pineal gland of normal and hexachlorobenzene-treated rats in order to find alterations potentially related to porphyria cutanea tarda. Results show that in animals with this experimental porphyria some tryptophan metabolite levels (serotonin and 5-hydroxyindoleacetic acid) increase only during the light period, whereas tryptophan content remained equal to the controls. Hydroxyindole-O-methyltransferase activity also increases by light in pineal gland from hexachlorobenzene-treated rats. On the other hand, tryptophan is converted to melatonin in the dark period, but this route is not exacerbated in hexachlorobenzene porphyria. The relevance of these alterations is discussed in relation to hyperpigmentation, neoplastic and oxidative stress processes associated with this porphyria. Copyright © American College of Toxicology.

Registro:

Documento: Artículo
Título:Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria
Autor:Llambías, E.B.C.; Mazzetti, M.B.; Lelli, S.M.; Aldonatti, C.; De Viale, L.C.S.M.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Ciudad Universitaria, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Pabellón II, (1428) Buenos Aires, Argentina
Palabras clave:Experimental Hepatic Porphyria; Hexachlorobenzene; Melatonin; Porphyria Cutanea Tarda; Tryptophan; Tryptophan Metabolites; 5 hydroxyindoleacetic acid; acetylserotonin methyltransferase; hexachlorobenzene; melatonin; serotonin; tryptophan; animal experiment; animal model; animal tissue; article; controlled study; enzyme activity; female; hyperpigmentation; nonhuman; oxidative stress; pineal body; porphyria cutanea tarda; rat; Acetylserotonin O-Methyltransferase; Animals; Circadian Rhythm; Disease Models, Animal; Female; Hexachlorobenzene; Hydroxyindoleacetic Acid; Light; Melatonin; Pineal Gland; Porphyria Cutanea Tarda; Rats; Rats, Wistar; Serotonin; Tryptophan; Tryptophan Hydroxylase; Animalia; Rattus
Año:2007
Volumen:26
Número:6
Página de inicio:545
Página de fin:551
DOI: http://dx.doi.org/10.1080/10915810701707643
Título revista:International Journal of Toxicology
Título revista abreviado:Int. J. Toxicol.
ISSN:10915818
CODEN:IJTOF
CAS:5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; acetylserotonin methyltransferase, 9029-77-0; hexachlorobenzene, 118-74-1, 55600-34-5; melatonin, 73-31-4; serotonin, 50-67-9; tryptophan, 6912-86-3, 73-22-3; Acetylserotonin O-Methyltransferase, EC 2.1.1.4; Hexachlorobenzene, 118-74-1; Hydroxyindoleacetic Acid, 54-16-0; Melatonin, 73-31-4; N-acetylserotonin, 1210-83-9; Serotonin, 50-67-9; Tryptophan Hydroxylase, EC 1.14.16.4; Tryptophan, 73-22-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10915818_v26_n6_p545_Llambias

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Citas:

---------- APA ----------
Llambías, E.B.C., Mazzetti, M.B., Lelli, S.M., Aldonatti, C. & De Viale, L.C.S.M. (2007) . Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria. International Journal of Toxicology, 26(6), 545-551.
http://dx.doi.org/10.1080/10915810701707643
---------- CHICAGO ----------
Llambías, E.B.C., Mazzetti, M.B., Lelli, S.M., Aldonatti, C., De Viale, L.C.S.M. "Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria" . International Journal of Toxicology 26, no. 6 (2007) : 545-551.
http://dx.doi.org/10.1080/10915810701707643
---------- MLA ----------
Llambías, E.B.C., Mazzetti, M.B., Lelli, S.M., Aldonatti, C., De Viale, L.C.S.M. "Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria" . International Journal of Toxicology, vol. 26, no. 6, 2007, pp. 545-551.
http://dx.doi.org/10.1080/10915810701707643
---------- VANCOUVER ----------
Llambías, E.B.C., Mazzetti, M.B., Lelli, S.M., Aldonatti, C., De Viale, L.C.S.M. Melatonin formation in pineal gland from rats with hexachlorobenzene experimental porphyria. Int. J. Toxicol. 2007;26(6):545-551.
http://dx.doi.org/10.1080/10915810701707643