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Doctorovich, F.; Bikiel, D.; Pellegrino, J.; Suárez, S.A.; Martí, M.A. "Stabilization and detection of nitroxyl by iron and cobalt porphyrins in solution and on surfaces" (2010) Journal of Porphyrins and Phthalocyanines. 14(12):1012-1018
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Abstract:

Nitroxyl (HNO/NO-) is a small short-lived molecule that has been suggested to be produced by nitric oxide (NO) synthases under certain conditions. As for NO, biologically relevant targets of HNO are mainly heme-proteins and therefore, it has been difficult to discriminate the physio-pathological role of each molecule conclusively. Therefore, accurate discrimination between them is still an unresolved matter. On the other hand, there is only scarce information about nitroxyl-metalloporphyrin complexes. Hence, there is growing interest in obtaining and characterizing stable heme model nitroxyl complexes. In this review we show how HNO and NO can be discriminated electrochemically by a Co porphyrin attached to a gold surface, and how nitroxyl can be stabilized by coordination to an electron-poor Fe porphyrin. The Co porphyrin with four anchors, cobalt(II)-5,10,15,20-tetrakis[3- (p-acetylthio-propoxy)phenyl]porphyrin [Co(P)] was covalently attached to gold electrodes, and its reactions with NO and HNO donors were studied electrochemically. By fixing the potential to values that oxidize Co III(P)NO-, HNO can be selectively detected by amperometric techniques. On the other hand, the one-electron chemical reduction of Fe II(TFPPBr8)NO (TFPPBr8 = 2,3,7,8,12,13,17,18- octa-β-bromo-5,10,15,20-[tetrakis-(pentafluorophenyl)]porphyrin) with cobaltocene yields the significantly stable {FeNO}8 nitroxyl anion complex, [Co(C5H5)2]+[Fe(TFPPBr 8)NO]-, which was isolated and characterized by several spectroscopies and DFT calculations. This species is intermediate between FeIINO- and FeINO, which is contrasted with the predominant FeIINO- character of known non-heme {FeNO}8 complexes. © 2010 World Scientific Publishing Company.

Registro:

Documento: Artículo
Título:Stabilization and detection of nitroxyl by iron and cobalt porphyrins in solution and on surfaces
Autor:Doctorovich, F.; Bikiel, D.; Pellegrino, J.; Suárez, S.A.; Martí, M.A.
Filiación:Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Química Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (1428) Buenos Aires, Argentina
Palabras clave:Angeli's salt; Co; electrochemistry; heme; HNO; metalloporphyrins; Mn; nitrosyl complex; nitroxyl; NO; Piloty's acid
Año:2010
Volumen:14
Número:12
Página de inicio:1012
Página de fin:1018
DOI: http://dx.doi.org/10.1142/S1088424610002914
Título revista:Journal of Porphyrins and Phthalocyanines
Título revista abreviado:J. Porphyrins Phthalocyanines
ISSN:10884246
CODEN:JPPHF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v14_n12_p1012_Doctorovich

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Citas:

---------- APA ----------
Doctorovich, F., Bikiel, D., Pellegrino, J., Suárez, S.A. & Martí, M.A. (2010) . Stabilization and detection of nitroxyl by iron and cobalt porphyrins in solution and on surfaces. Journal of Porphyrins and Phthalocyanines, 14(12), 1012-1018.
http://dx.doi.org/10.1142/S1088424610002914
---------- CHICAGO ----------
Doctorovich, F., Bikiel, D., Pellegrino, J., Suárez, S.A., Martí, M.A. "Stabilization and detection of nitroxyl by iron and cobalt porphyrins in solution and on surfaces" . Journal of Porphyrins and Phthalocyanines 14, no. 12 (2010) : 1012-1018.
http://dx.doi.org/10.1142/S1088424610002914
---------- MLA ----------
Doctorovich, F., Bikiel, D., Pellegrino, J., Suárez, S.A., Martí, M.A. "Stabilization and detection of nitroxyl by iron and cobalt porphyrins in solution and on surfaces" . Journal of Porphyrins and Phthalocyanines, vol. 14, no. 12, 2010, pp. 1012-1018.
http://dx.doi.org/10.1142/S1088424610002914
---------- VANCOUVER ----------
Doctorovich, F., Bikiel, D., Pellegrino, J., Suárez, S.A., Martí, M.A. Stabilization and detection of nitroxyl by iron and cobalt porphyrins in solution and on surfaces. J. Porphyrins Phthalocyanines. 2010;14(12):1012-1018.
http://dx.doi.org/10.1142/S1088424610002914