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Rodriguez, M.E.; Fernández, D.A.; Awruch, J.; Braslavsky, S.E.; Dicelio, L.E. "Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin" (2006) Journal of Porphyrins and Phthalocyanines. 10(1):33-42
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Abstract:

The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role. Copyright © 2006 Society of Porphyrins & Phthalocyanines.

Registro:

Documento: Artículo
Título:Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
Autor:Rodriguez, M.E.; Fernández, D.A.; Awruch, J.; Braslavsky, S.E.; Dicelio, L.E.
Filiación:INQUIMAE, Departamento de Química Inorgánica, Analítica Y Química Física, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Farmacia Y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Max-Planck-Institut für Bioanorganische Chemie (Formerly Strahlenchemie), Postfach 10 13 65, D-45413 Mülheim an der Ruhr, Germany
Tyrolit Argentina S.A. Boquerón 741-(B1708CRE), Morón, Argentina
Palabras clave:Aggregation; Albumin; Hydrophobic interactions; Micelles; Tetrakis(1,1- dimethyl-2-trimethylammonium)ethylphthalocyaninato zinc(II) tetraiodide
Año:2006
Volumen:10
Número:1
Página de inicio:33
Página de fin:42
DOI: http://dx.doi.org/10.1142/S1088424606000053
Título revista:Journal of Porphyrins and Phthalocyanines
Título revista abreviado:J. Porphyrins Phthalocyanines
ISSN:10884246
CODEN:JPPHF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v10_n1_p33_Rodriguez

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Citas:

---------- APA ----------
Rodriguez, M.E., Fernández, D.A., Awruch, J., Braslavsky, S.E. & Dicelio, L.E. (2006) . Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin. Journal of Porphyrins and Phthalocyanines, 10(1), 33-42.
http://dx.doi.org/10.1142/S1088424606000053
---------- CHICAGO ----------
Rodriguez, M.E., Fernández, D.A., Awruch, J., Braslavsky, S.E., Dicelio, L.E. "Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin" . Journal of Porphyrins and Phthalocyanines 10, no. 1 (2006) : 33-42.
http://dx.doi.org/10.1142/S1088424606000053
---------- MLA ----------
Rodriguez, M.E., Fernández, D.A., Awruch, J., Braslavsky, S.E., Dicelio, L.E. "Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin" . Journal of Porphyrins and Phthalocyanines, vol. 10, no. 1, 2006, pp. 33-42.
http://dx.doi.org/10.1142/S1088424606000053
---------- VANCOUVER ----------
Rodriguez, M.E., Fernández, D.A., Awruch, J., Braslavsky, S.E., Dicelio, L.E. Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin. J. Porphyrins Phthalocyanines. 2006;10(1):33-42.
http://dx.doi.org/10.1142/S1088424606000053