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Abstract:

Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinatal inflammation can affect various behaviors relevant to psychiatric disorders such as schizophrenia, autism, anxiety and depression. Remarkably, the effects on behavior and brain function do not always depend on the type of inflammatory stimulus or the perinatal age targeted, so diverse inflammatory events can have similar consequences on the brain. Moreover, other perinatal environmental factors that affect behavior (e.g. diet and stress) also elicit inflammatory responses. Understanding the interplay between perinatal environment and inflammation on brain development is required to identify the mechanisms through which perinatal inflammation affect brain function in the adult animal. Evidence for the role of the peripheral immune system and glia on perinatal programming of behavior is discussed in this review, along with recent evidence for the role of epigenetic mechanisms affecting gene expression in the brain. © 2017 Elsevier Ltd

Registro:

Documento: Artículo
Título:Perinatal inflammation and adult psychopathology: From preclinical models to humans
Autor:Depino, A.M.
Filiación:Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Fisiologia, Biologia Molecular y Celular, Buenos Aires, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Fisiologia, Biologia Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina
Palabras clave:Anxiety; Autism; Depression; Perinatal inflammation; Psychiatric disease; Rodent; Schizophrenia; adult; anxiety; autism; brain development; brain function; depression; disease predisposition; environmental factor; epigenetics; gene expression; glia; human; immune system; inflammation; maternal nutrition; mental disease; newborn; nonhuman; obesity; perinatal morbidity; preclinical study; Review; schizophrenia; stress; animal; autism; behavior; brain; depression; female; growth, development and aging; inflammation; mental disease; mouse; pathology; physiology; pregnancy; pregnancy complication; psychology; rat; schizophrenia; Animals; Anxiety; Autistic Disorder; Behavior; Brain; Depression; Female; Humans; Inflammation; Mental Disorders; Mice; Pregnancy; Pregnancy Complications, Infectious; Psychopathology; Rats; Schizophrenia
Año:2018
Volumen:77
Página de inicio:104
Página de fin:114
DOI: http://dx.doi.org/10.1016/j.semcdb.2017.09.010
Título revista:Seminars in Cell and Developmental Biology
Título revista abreviado:Semin. Cell. Dev. Biol.
ISSN:10849521
CODEN:SCDBF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10849521_v77_n_p104_Depino

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Citas:

---------- APA ----------
(2018) . Perinatal inflammation and adult psychopathology: From preclinical models to humans. Seminars in Cell and Developmental Biology, 77, 104-114.
http://dx.doi.org/10.1016/j.semcdb.2017.09.010
---------- CHICAGO ----------
Depino, A.M. "Perinatal inflammation and adult psychopathology: From preclinical models to humans" . Seminars in Cell and Developmental Biology 77 (2018) : 104-114.
http://dx.doi.org/10.1016/j.semcdb.2017.09.010
---------- MLA ----------
Depino, A.M. "Perinatal inflammation and adult psychopathology: From preclinical models to humans" . Seminars in Cell and Developmental Biology, vol. 77, 2018, pp. 104-114.
http://dx.doi.org/10.1016/j.semcdb.2017.09.010
---------- VANCOUVER ----------
Depino, A.M. Perinatal inflammation and adult psychopathology: From preclinical models to humans. Semin. Cell. Dev. Biol. 2018;77:104-114.
http://dx.doi.org/10.1016/j.semcdb.2017.09.010