Navegar

Colección

Datos Estadísticas

Artículo

Waxman, S.; Prados, A.P.; De Lucas, J.; Andres, M.I.S.; Sassaroli, J.C.; Orozco, M.; Argibay, H.; Rodriguez, C. "Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)" (2013) Journal of Avian Medicine and Surgery. 27(3):180-186
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

To determine the dosage of enrofloxacin in southern crested caracaras (Caracara plancus), plasma concentrations of enrofloxacin were measured by high-performance liquid chromatography after intravenous (IV) (5 mg/kg) and intramuscular (IM) (10 mg/kg) administration. This compound presented a relatively high volume of distribution (2.09 L/kg), a total body clearance of 0.24 L/kg·h, and a long permanence as shown by an elimination half-life of 7.81 hours after IV administration and a terminal half-life of 6.58 hours after IM administration. The areas under the concentration-time curves (AUC) were 21.92 and 34.38 μg·h/mL for IM and IV administration, respectively. Enrofloxacin was rapidly absorbed after IM administration with a time to reach maximum concentration of 0.72 hours and bioavailability of 78.76%. After IM administration, the peak drug concentration (Cmax) was 3.92 μg/mL. Values of minimum inhibitory concentration (MIC), Cmax, and AUC have been used to predict the clinical efficacy of a drug in treating bacterial infections, with a Cmax/MIC value of 10 and an AUC/MIC ratio of 125-250 associated with optimal bactericidal effects. By using the study data and a MIC breakpoint of 0.25 μg/mL, values of Cmax/MIC were 13.74 and 15.94 and for AUC/MIC were 90.73 and 139.63, for the IV and IM routes respectively. For the treatment of infectious diseases caused by microorganisms with MIC ≤0.25 μg/mL, the calculated optimal dosages were 7.5 and 9.5 mg/kg q24h by the IV and IM routes, respectively. For less susceptible bacteria, a dose increase should be evaluated. To treat caracara by the IV route against microorganisms with MIC ≤0.25 μg/mL, the dose should be higher than the 5 mg/kg used in our study, but possible side effects derived from an increase in the IV dose and efficacy in sick birds should be assessed. © 2013 by the Association of Avian Veterinarians.

Registro:

Documento: Artículo
Título:Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
Autor:Waxman, S.; Prados, A.P.; De Lucas, J.; Andres, M.I.S.; Sassaroli, J.C.; Orozco, M.; Argibay, H.; Rodriguez, C.
Filiación:Pharmacology Department, FCV, University of Buenos Aires, Chorroarin 280, 1427, Argentina
Pharmacology Department, Universidad Complutense de Madrid, Av. Puerta de Hierro s/n, 28040, Spain
Reserva Ecológica Costanera Sur, T. A. Rodriguez 1550, 1107, Buenos Aires, Argentina
Ecoepidemiology Laboratory, FCEN, UBA, C. Universitaria, 1428, Buenos Aires, Argentina
Ecological Park El Puma, MEYRNR, Candelaria, 3308, Misiones, Argentina
Palabras clave:Caracara plancus; Enrofloxacin; Fluoroquinolones pharmacokinetics; Pharmacodynamics; Southern creasted caracars; antiinfective agent; ciprofloxacin; enrofloxacin; quinolone derivative; animal; area under the curve; article; bird; blood; Campylobacter jejuni; clinical trial; drug effect; Escherichia coli; half life time; metabolism; microbial sensitivity test; Animals; Anti-Bacterial Agents; Area Under Curve; Birds; Campylobacter jejuni; Ciprofloxacin; Escherichia coli; Fluoroquinolones; Half-Life; Microbial Sensitivity Tests
Año:2013
Volumen:27
Número:3
Página de inicio:180
Página de fin:186
DOI: http://dx.doi.org/10.1647/2012-022
Título revista:Journal of Avian Medicine and Surgery
Título revista abreviado:J. Avian Med. Surg.
ISSN:10826742
CAS:ciprofloxacin, 85721-33-1; enrofloxacin, 93106-60-6; Anti-Bacterial Agents; Ciprofloxacin, 5E8K9I0O4U; Fluoroquinolones; enrofloxacin, 93106-60-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10826742_v27_n3_p180_Waxman

Referencias:

  • Sharma, P.C., Jain, A., Jain, S., Fluoroquinolone antibacterials: A review on chemistry, microbiology and therapeutic prospects (2009) Acta Pol Pharm, 66 (6), pp. 587-604
  • Bailey, T.A., Sheen, R.S., Silvanose, C., Pharmacokinetics of enrofloxacin after intravenous, intramuscular and oral administration in houbara bustard (Chlamydotis undulata macqueenii (1998) J Vet Pharmacol Ther, 21 (4), pp. 288-297
  • Papich, M.G., Drug therapy and selection in exotic medicine (2003) Compend Cont Educ Pract Vet, 25, pp. 15-20. , suppl A
  • Dimitrova, D.J., Lashev, L.D., Yanev, S.G., Pandova, B., Pharmacokinetics of enrofloxacin in turkeys (2007) Res Vet Sci, 82 (3), pp. 392-397
  • De Lucas, J.J., Rodriguez, C., Martella, M.B., Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: A preliminary study (2005) Res Vet Sci, 78 (3), pp. 265-267
  • Bugyei, K., Black, W.D., McEwen, S., Pharmacokinetics of enrofloxacin given by the oral, intravenous and intramuscular routes in broiler chickens (1999) Can J Vet Res, 63 (3), pp. 193-200
  • De Lucas, J.J., Rodriguez, C., Waxman, S., Pharmacokinetics of enrofloxacin after single intravenous and intramuscular administration to young domestic ostrich (Struthio camelus (2004) J Vet Pharmacol Ther, 27 (2), pp. 119-122
  • Harrenstien, L.A., Tell, L.A., Vulliet, R., Disposition of enrofloxacin in red-Tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus) after a single oral, intramuscular, or intravenous dose (2000) J Avian Med Surg, 14 (3), pp. 228-236
  • Intorre, L., Mengozzi, G., Bertini, S., The plasma kinetics and tissue distribution of enrofloxacin and its metabolite ciprofloxacin in the muscovy duck (1997) Vet Res Commun, 21 (2), pp. 127-136
  • Papich, M.G., Riviere, J.E., Fluoroquinolone antimicrobial drugs (2001) Veterinary Pharmacology and Therapeutics, pp. 898-917. , Adams HR, ed. 8th ed. Ames IA: Iowa State University Press
  • Krautwald, M.E., Pieper, K., Rullof, R., Further experiences with the use of baytril in pet birds (1990) Proc Annu Conf Assoc Avian Vet, pp. 226-236
  • Maaaaaaslanka, T., Jaroszewski, J.J., Effect of long-Term treatment with therapeutic doses of enrofloxacin on chicken articular cartilage (2009) Pol J Vet Sci, 12 (3), pp. 363-367
  • Li, Q., Bi, X., Diao, Y., Deng, X., Mutant-prevention concentrations of enrofloxacin for Escherichia coli isolates from chickens (2007) Am J Vet Res, 68 (8), pp. 812-815
  • Wang, L., Yuanshu, Z., Yuhan, Z., Mutant prevention concentrations of fluoroquinolones against Campylobacter jejuni isolated from chicken (2010) Vet Microbiol, 144 (3-4), pp. 409-414
  • Flammer, K., Antibiotic drug selection in companion birds (2006) J Exotic Pet Med, 15 (3), pp. 166-176
  • McKellar, Q.A., Sanchez Bruni, S.F., Jones, D.G., Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine (2004) J Vet Pharmacol Ther, 27 (6), pp. 503-514
  • Walker, R.D., Fluoroquinolones (2000) Antimicrobial Therapy in Veterinary Medicine, pp. 315-338. , Prescott JF, Baggot JD, Walker RD, eds. 3rd ed. Ames, IA: Iowa State University Press
  • Toutain, P.L., Del Castillo, J.R.E., Bousquet-Melou, A., The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics (2002) Res Vet Sci, 73 (2), pp. 105-114
  • Olofsson, S.K., Marcusson, L.L., Komp Lindgren, P., Selection of ciprofloxacin resistance in Escherichia coli in an in vitro kinetic model: Relation between drug exposure and mutant prevention concentration (2006) J Antimicrob Chemother, 57 (6), pp. 1116-1121
  • Ferran, A.A., Kesteman, A.S., Toutain, P.L., Bousquet-Maaaaaelou, A., Pharmacokinetic/pharmacodynamic analysis of the influence of inoculum size on the selection of resistance in Escherichia coli by a quinolone in a mouse thigh bacterial infection model (2009) Antimicrob Agents Chemother, 53 (8), pp. 3384-3390
  • Pollock, C., Carpenter, J.W., Antinoff, N., Birds (2005) Exotic Animal Formulary, pp. 135-315. , Carpenter JW. 3rd ed. St Louis MO: Elsevier Saunders

Citas:

---------- APA ----------
Waxman, S., Prados, A.P., De Lucas, J., Andres, M.I.S., Sassaroli, J.C., Orozco, M., Argibay, H.,..., Rodriguez, C. (2013) . Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus). Journal of Avian Medicine and Surgery, 27(3), 180-186.
http://dx.doi.org/10.1647/2012-022
---------- CHICAGO ----------
Waxman, S., Prados, A.P., De Lucas, J., Andres, M.I.S., Sassaroli, J.C., Orozco, M., et al. "Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)" . Journal of Avian Medicine and Surgery 27, no. 3 (2013) : 180-186.
http://dx.doi.org/10.1647/2012-022
---------- MLA ----------
Waxman, S., Prados, A.P., De Lucas, J., Andres, M.I.S., Sassaroli, J.C., Orozco, M., et al. "Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)" . Journal of Avian Medicine and Surgery, vol. 27, no. 3, 2013, pp. 180-186.
http://dx.doi.org/10.1647/2012-022
---------- VANCOUVER ----------
Waxman, S., Prados, A.P., De Lucas, J., Andres, M.I.S., Sassaroli, J.C., Orozco, M., et al. Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus). J. Avian Med. Surg. 2013;27(3):180-186.
http://dx.doi.org/10.1647/2012-022