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Fernanda Ledda, M.; Adris, S.; Bravo, A.I.; Kairiyama, C.; Bover, L.; Chernajovsky, Y.; Mordoh, J.; Podhajcer, O.L. "Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells" (1997) Nature Medicine. 3(2):171-176
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Abstract:

Acquisition of invasive/metastatic potential is a key event in tumor progression. Cell surface glycoproteins and their respective matrix ligands have been implicated in this process. Recent evidence reveals that the secreted glycoprotein SPARC (secreted protein, acidic and rich in cysteine) is highly expressed in different malignant tissues. The present study reports that the suppression of SPARC expression by human melanoma cells using a SPARC antisense expression vector results in a significant decrease in the in vitro adhesive and invasive capacities of tumor cells, completely abolishing their in vivo tumorigenicity. This is the first evidence that SPARC plays a key role in human melanoma invasive-metastatic phenotype development.

Registro:

Documento: Artículo
Título:Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells
Autor:Fernanda Ledda, M.; Adris, S.; Bravo, A.I.; Kairiyama, C.; Bover, L.; Chernajovsky, Y.; Mordoh, J.; Podhajcer, O.L.
Filiación:Lnstituto de Invest. Bioquimicas, Fundacion Campomar, IIBBA-CONICET, Patricias Argentinas 435, 1405 Buenos Aires, Argentina
Fac. Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Hospital E. Peron, Balcarce 900, 1650 Provincia de Buenos Aires, Argentina
Kennedy Institute of Rheumatology, 6 Bute Gardens, London W6 7DW, United Kingdom
Palabras clave:complementary rna; glycoprotein; osteonectin; animal experiment; article; cancer inhibition; cancer invasion; controlled study; human; human cell; melanoma cell; metastasis; mouse; nonhuman; priority journal; Animals; Cell Adhesion; Cell Division; Cell Movement; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma, Experimental; Mice; Oligonucleotides, Antisense; Osteonectin; Transfection; Tumor Cells, Cultured; Animalia
Año:1997
Volumen:3
Número:2
Página de inicio:171
Página de fin:176
DOI: http://dx.doi.org/10.1038/nm0297-171
Título revista:Nature Medicine
Título revista abreviado:NAT. MED.
ISSN:10788956
CODEN:NAMEF
CAS:Oligonucleotides, Antisense; Osteonectin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10788956_v3_n2_p171_FernandaLedda

Referencias:

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Citas:

---------- APA ----------
Fernanda Ledda, M., Adris, S., Bravo, A.I., Kairiyama, C., Bover, L., Chernajovsky, Y., Mordoh, J.,..., Podhajcer, O.L. (1997) . Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells. Nature Medicine, 3(2), 171-176.
http://dx.doi.org/10.1038/nm0297-171
---------- CHICAGO ----------
Fernanda Ledda, M., Adris, S., Bravo, A.I., Kairiyama, C., Bover, L., Chernajovsky, Y., et al. "Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells" . Nature Medicine 3, no. 2 (1997) : 171-176.
http://dx.doi.org/10.1038/nm0297-171
---------- MLA ----------
Fernanda Ledda, M., Adris, S., Bravo, A.I., Kairiyama, C., Bover, L., Chernajovsky, Y., et al. "Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells" . Nature Medicine, vol. 3, no. 2, 1997, pp. 171-176.
http://dx.doi.org/10.1038/nm0297-171
---------- VANCOUVER ----------
Fernanda Ledda, M., Adris, S., Bravo, A.I., Kairiyama, C., Bover, L., Chernajovsky, Y., et al. Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells. NAT. MED. 1997;3(2):171-176.
http://dx.doi.org/10.1038/nm0297-171