Artículo
Cabrera, G.M.; Fernandez Murga, M.L.; De Font Valdez, G.; Seldes, A.M. "Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry" (2000) Journal of Mass Spectrometry. 35(12):1460-1469
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Abstract:
The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometry (SIMS). In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles. When soil samples spiked with HN-3 in alcohol were analyzed, 2-alkoxyethylamine derivatives were observed on the sample surfaces. This result shows that nitrogen blister agents will undergo condensation reactions with nucleophilic compounds and emphasizes the need for an analytical methodology capable of detecting a range of degradation and condensation products on environmental surfaces. The ability of ion trap SIMS to isolate and accumulate ions, and then perform tandem mass spectrometric analysis improves the detection of low-abundance surface contaminants and the selectivity of the technique. Utilizing these techniques, the limits of detection for HN-3 were studied as a function of surface coverage. It was found that HN-3 could be detected at a surface coverage of 0.01 monolayer, which corresponds to 20 ppm (mass/mass) for a soil having a surface area of 2.2 m2 g-1. TEA, the exhaustive hydrolysis product of HN-3, was detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm. Copyright © 2000 John Wiley & Sons, Ltd.
Registro:
| Documento: | Artículo |
| Título: | Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| Autor: | Cabrera, G.M.; Fernandez Murga, M.L.; De Font Valdez, G.; Seldes, A.M. |
| Filiación: | Departamento de Quimica Organica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina Centro de Referencia de Lactobacilos, Chacabuco 145, 4000 San Miguel de Tucuman, Tucuman, Argentina |
| Palabras clave: | Chemical weapons agents; HN-2; HN-3; Secondary ion mass spectrometry; Surface analysis; Vesicants; chlormethine; nitrogen derivative; trichlormethine; analytic method; article; chemical analysis; chemical reaction; hydrolysis; mass spectrometry; polymerization; priority journal; reaction analysis; soil; 3,4-Methylenedioxyamphetamine; Chemical Warfare Agents; Ethanolamines; Hydrolysis; Irritants; Mechlorethamine; Nitrogen Mustard Compounds; Soil; Spectrometry, Mass, Secondary Ion |
| Año: | 2000 |
| Volumen: | 35 |
| Número: | 12 |
| Página de inicio: | 1460 |
| Página de fin: | 1469 |
| DOI: | http://dx.doi.org/10.1002/1096-9888(200012)35:12<1460::AID-JMS82>3.0.CO;2-J |
| Título revista: | Journal of Mass Spectrometry |
| Título revista abreviado: | J. Mass Spectrom. |
| ISSN: | 10765174 |
| CODEN: | JMSPF |
| CAS: | 2,2',2''-trichlorotriethylamine, 555-77-1; 3,4-Methylenedioxyamphetamine, 4764-17-4; 3,4-methylenedioxyethamphetamine, 82801-81-8; Chemical Warfare Agents; Ethanolamines; Irritants; Mechlorethamine, 51-75-2; N-methyldiethanolamine, 105-59-9; Nitrogen Mustard Compounds; Soil; triethanolamine, 102-71-6 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10765174_v35_n12_p1460_Cabrera |
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Citas:
---------- APA ----------
Cabrera, G.M., Fernandez Murga, M.L., De Font Valdez, G. & Seldes, A.M. (2000) . Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry. Journal of Mass Spectrometry, 35(12), 1460-1469.http://dx.doi.org/10.1002/1096-9888(200012)35:12<1460::AID-JMS82>3.0.CO;2-J
---------- CHICAGO ----------
Cabrera, G.M., Fernandez Murga, M.L., De Font Valdez, G., Seldes, A.M. "Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry" . Journal of Mass Spectrometry 35, no. 12 (2000) : 1460-1469.http://dx.doi.org/10.1002/1096-9888(200012)35:12<1460::AID-JMS82>3.0.CO;2-J
---------- MLA ----------
Cabrera, G.M., Fernandez Murga, M.L., De Font Valdez, G., Seldes, A.M. "Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry" . Journal of Mass Spectrometry, vol. 35, no. 12, 2000, pp. 1460-1469.http://dx.doi.org/10.1002/1096-9888(200012)35:12<1460::AID-JMS82>3.0.CO;2-J
---------- VANCOUVER ----------
Cabrera, G.M., Fernandez Murga, M.L., De Font Valdez, G., Seldes, A.M. Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry. J. Mass Spectrom. 2000;35(12):1460-1469.http://dx.doi.org/10.1002/1096-9888(200012)35:12<1460::AID-JMS82>3.0.CO;2-J
