Abstract:
OBJECTIVE:: Analyze disability determinants in a cohort of Argentine patients with rheumatoid arthritis (RA). MATERIAL AND METHODS:: Consecutive patients with RA, according to ACR87 criteria, were recruited from 6 rheumatology centers. Demographic and socioeconomic data, family history, comorbid diseases, extra-articular manifestations and information about received treatments were provided. Disease activity was assessed using Disease Activity Score 28 (DAS 28) and the Health Assessment Questionnaire (HAQ)-A was used for the functional capacity. Hand and feet radiographs were assessed using Sharp-van der Heijde score. RESULTS:: A total of 640 patients with RA were included, of which 85.2% were females. Mean age was 53 years (interquartile range [IQR], 44-62) and mean disease duration was 8 years (IQR, 4-14). DAS 28 mean was 2.72 (IQR, 1.7-3.7) and HAQ-A mean was 0.62 (IQR, 0.13-1.25). Multiple linear regression showed that the main variables associated with disability were DAS 28, radiologic damage and age. Main predictors of functional disability in the multiple logistic regression using severe HAQ (>2) as dependent variable were DAS 28 (OR, 2; P < 0.0001); age (OR, 1; P = 0.008); and structural damage (OR, 1; P = 0.001). CONCLUSIONS:: In this population, the disease activity was the variable that showed the highest impact on the physical function. Radiologic damage affected HAQ as the disease progressed. © 2010 by Lippincott Williams & Wilkins.
Registro:
Documento: |
Artículo
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Título: | Factors associated with disability in patients with rheumatoid arthritis |
Autor: | Schneeberger, E.E.; Citera, G.; Maldonado Cocco, J.A.; Salcedo, M.; Chiardola, F.; Rosemffet, M.G.; Marengo, M.F.; Papasidero, S.; Chaparro Del Moral, R.; Rillo, O.L.; Bellomio, V.; Lucero, E.; Spindler, A.; Berman, A.; Duartes Noe, D.; Barreira, J.C.; Lázaro, M.A.; Paira, S.O. |
Filiación: | Instituto de Rehabilitación Psicofísica, Echeverria 955, Buenos Aires, 1428, Argentina Hospital Tornú, Buenos Aires, Argentina Hospital Padilla, Tucumán, Argentina Hospital Británico, Buenos Aires, Argentina Hospital Cullen Santa Fé, Fundación Reumatológica Argentina dr O García Morteo, Santa Fé, Argentina
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Palabras clave: | discapacity; disease activity; rheumatoid arthritis; adult; Argentina; article; comorbidity; controlled study; demography; dependent variable; disability; disease activity; disease duration; family history; female; functional status; Health Assessment Questionnaire; human; major clinical study; male; multiple linear regression analysis; priority journal; radiography; rheumatoid arthritis; socioeconomics; Adult; Antirheumatic Agents; Argentina; Arthritis, Rheumatoid; Cohort Studies; Comorbidity; Disability Evaluation; Disease Progression; Female; Foot Joints; Hand Joints; Health Surveys; Humans; Logistic Models; Male; Middle Aged; Severity of Illness Index |
Año: | 2010
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Volumen: | 16
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Número: | 5
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Página de inicio: | 215
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Página de fin: | 218
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DOI: |
http://dx.doi.org/10.1097/RHU.0b013e3181e92d25 |
Título revista: | Journal of Clinical Rheumatology
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Título revista abreviado: | J. Clin. Rheumatol.
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ISSN: | 10761608
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CODEN: | JCRHF
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CAS: | Antirheumatic Agents
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10761608_v16_n5_p215_Schneeberger |
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Citas:
---------- APA ----------
Schneeberger, E.E., Citera, G., Maldonado Cocco, J.A., Salcedo, M., Chiardola, F., Rosemffet, M.G., Marengo, M.F.,..., Paira, S.O.
(2010)
. Factors associated with disability in patients with rheumatoid arthritis. Journal of Clinical Rheumatology, 16(5), 215-218.
http://dx.doi.org/10.1097/RHU.0b013e3181e92d25---------- CHICAGO ----------
Schneeberger, E.E., Citera, G., Maldonado Cocco, J.A., Salcedo, M., Chiardola, F., Rosemffet, M.G., et al.
"Factors associated with disability in patients with rheumatoid arthritis"
. Journal of Clinical Rheumatology 16, no. 5
(2010) : 215-218.
http://dx.doi.org/10.1097/RHU.0b013e3181e92d25---------- MLA ----------
Schneeberger, E.E., Citera, G., Maldonado Cocco, J.A., Salcedo, M., Chiardola, F., Rosemffet, M.G., et al.
"Factors associated with disability in patients with rheumatoid arthritis"
. Journal of Clinical Rheumatology, vol. 16, no. 5, 2010, pp. 215-218.
http://dx.doi.org/10.1097/RHU.0b013e3181e92d25---------- VANCOUVER ----------
Schneeberger, E.E., Citera, G., Maldonado Cocco, J.A., Salcedo, M., Chiardola, F., Rosemffet, M.G., et al. Factors associated with disability in patients with rheumatoid arthritis. J. Clin. Rheumatol. 2010;16(5):215-218.
http://dx.doi.org/10.1097/RHU.0b013e3181e92d25